Foto på Emmy Verschuren
  • PL 20 (Tukholmankatu 8)

    00014

    Finland

19972019
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Personlig profil

Information om forskning och undervisning

Background

Lung cancer remains the leading cause of cancer-related mortality worldwide. Curing late stage disseminated lung cancer is challenging, as cell populations are highly heterogeneous both molecularly and histologically, and often genomically unstable. Despite promising progress in treatment strategies that harness anti-tumour immunity, therapeutic resistance limits clinical efficacy. A shift to early cancer detection and prevention is therefore necessary, and this requires an improved understanding of the biological basis of cancer initiation in its physiological niche.

 

Research Overview

We take a comprehensive approach to tackle challenges in the field of lung cancer research, progressing from mouse model systems of cancer to human disease cohorts. First, tumour-initiating events are identified in murine lung cancer cohorts, comprised of validated and putative driver combinations expressed in tissue progenitor cells. Second, we apply pathology-specific functional and immune profiling studies to identify drivers of malignancy. Third, we implement a mouse-to-patient comparative personalised medicine study, establishing the ability of cultured cells and tissue explants to reliably predict or validate in vivo drug sensitivities.

 

Research Directions

Foreseeing rapid technological advances in personalised cancer diagnostics, we aim to implement our gained insights in the rational design of cancer treatment and intervention strategies. To achieve these goals, our research increasingly interfaces with biobanking and translational infrastructures available at FIMM, associated Life Science Biocentres, and the Helsinki University Hospital. We collaborate with pulmonary surgeons, clinicians and pathologists to implement personalised disease profiling on patient tumour samples. These efforts will permit us to evaluate whether the functional diagnostic elucidation of patient tumour-selective therapeutic vulnerabilities has the potential to benefit the health of locally-treated cancer patients.

Fields of Science

  • 3111 Biomedicine
  • 3122 Cancers

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper
  • 3122 Cancersjukdomar

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1997 2019

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras Mutant Lung Cancers

Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K. M., Mäyränpää, M. I., Wennerberg, K. & Verschuren, E., okt 2019, I : Molecular Cancer Therapeutics. 18, 10, s. 1863-1874 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer

Bao, J., Walliander, M., Kovacs, F., Nagaraj, A. S., Hemmes, A., Sarhadi, V. K., Knuutila, S., Lundin, J., Horvath, P. & Verschuren, E. W., 26 nov 2019, I : Scientific Reports. 9, 11 s., 17613.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Nagaraj, A. S., Bao, J., Hemmes, A., Machado, M., Närhi, K. & Verschuren, E. W., 29 nov 2018, I : Journal of Visualized Experiments. 141, 9 s., e58569.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis

Devlin, J. R. & Verschuren, E. W., aug 2018, I : American Journal of Respiratory Cell and Molecular Biology. 59, 2, s. 141-142 2 s.

Forskningsoutput: TidskriftsbidragLedareVetenskaplig

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., Lahtela, J., Uotinen, V., Mäyränpää, M. I., Salmenkivi, K., Räsänen, J., Linder, N., Trapman, J., Rannikko, A., Kallioniemi, O., Af Hällström, T. M., Lundin, J., Sommergruber, W., Anders, S. & Verschuren, E. W., maj 2018, I : Journal of Pathology. 245, 1, s. 101-113 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

Projekter 2011 2016

PREDECT

Verschuren, E., Kallioniemi, O., Klefström, J., Monni, O. & Kovanen, P.

01/02/201131/01/2016

Projekt: Forskningsprojekt

Aktiviteter 2009 2009

  • 1 Handledning av annat kunskapsprov (pro gradu, licentiatavhandling)

BS. thesis supervisor of summer trainee Katariina Lassila

Emmy Verschuren (Handledare)
20092010

Aktivitet: ExaminationstyperHandledning av annat kunskapsprov (pro gradu, licentiatavhandling)

Press / media

Press Release IMI-PREDECT consortium

Emmy Verschuren

12/05/2011

1 Mediabidrag

Press/media: !!Press / Media