• PL 63 (Haartmaninkatu 8), 4023

    HELSINGIN YLIOPISTO

    Finland

  • PL 66 (Agnes Sjöbergin katu 2)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

  • PL 63 (Haartmaninkatu 8), 4021

    HELSINGIN YLIOPISTO

    Finland

  • Finland

19992019
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Personlig profil

Information om forskning och undervisning

Our research is focused on the development of canine models of human complex diseases. We take advantage of an experiment initiated by man ~15,000 years ago, taming of the wolf and, more recently, generating 400 strictly inbred pure dog breeds.  Canine purebreeding has resulted in highly uniform genomes within each breed, in which the “noise” of background genetic variation is reduced making it easier to detect genetic “signals” that contribute to disease.  That alone would not be very helpful without the fact that several of the essential components of most disease phenotypes can be found and measured in dogs. Dog is a large animal and clinically and physiologically close to human than typical laboratory rodent models. Dogs develop biologically analogous, if not homologous, conditions to human genetic disorders. Canine disorders usually respond to human medications and also other clinical and phenomenological studies suggest that these traits may share biological mechanisms across species. We aim to utilize this unique genetic system to identify new genes for morphology, behavior and various disorders.  Towards our aims, we have established one of the largest Dog DNA biobanks in the world with >80 000 samples from 330 different breeds. 
Although we work with many genetic traits in dogs, our research focuses on neurological, neurodegenerative and neurobehavioral conditions such as common epilepsy, ataxia and anxiety.  We have already mapped several new loci and genes in these disorders and believe that the natural canine models provide clinically and physiologically relevant models to corresponding human diseases. Comparison of the identified loci, genes and pathways across species will establish dogs as novel therapeutic models to understand the molecular pathogenesis of these complex traits. Meanwhile, breeders will benefit from the new DNA markers developed to identify the carriers for improved breeding plans. Our research has also led to novel successful commercial diagnostic innovations such as the first advanced gene panel test for dogs, MyDogDNA (www.mydogdna.com), and a NMR-based serum metabolomics test, PetMETA, available from PetBiomics (www.petbiomics.com). These high-resolution tests are transforming the diagnostics in veterinary medicine and breeding programs globally.

More on our research:

www.koirangeenit.fi

www.kissangeenit.fi

Externa befattningar

Adjunct Professor, University of Guelph

maj 2013 → …

Keywords

  • 3111 Biomedicinska vetenskaper
  • 1184 Genetik, utvecklingsbiologi, fysiologi
  • 413 Veterinärvetenskap
  • 3112 Neurovetenskaper

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1999 2019

Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs

Holden, L. A., Arumilli, M., Hytonen, M. K., Hundi, S., Salojärvi, J., Brown, K. H. & Lohi, H., 18 jul 2018, I : Scientific Reports. 8, 11 s., 10862.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Myotonia congenita in a Labrador Retriever with truncated CLCN1

Quitt, P. R., Hytönen, M. K., Matiasek, K., Rosati, M., Fischer, A. & Lohi, H., jul 2018, I : Neuromuscular Disorders. 28, 7, s. 597-605 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease

Kaukonen, M., Woods, S., Ahonen, S., Lemberg, S., Hellman, M., Hytönen, M. K., Permi, P., Glaser, T. & Lohi, H., 29 maj 2018, I : Cell Reports. 23, 9, s. 2643-2652 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs

Donner, J., Anderson, H., Davison, S., Hughes, A. M., Bouirmane, J., Lindqvist, J., Lytle, K. M., Ganesan, B., Ottka, C., Ruotanen, P., Kaukonen, M., Forman, O. P., Fretwell, N., Cole, C. A. & Lohi, H., apr 2018, I : PLoS Genetics. 14, 4, 20 s., 1007361.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Projekter 2013 2017

Koiran oksitosiini

Pekkin, A., Hänninen, L., Koskela, A., Tiira, K., Pöytäkangas, M., Lohi, H. & Valros, A.

Unknown funder

01/11/201331/10/2017

Projekt: Forskningsprojekt

Datauppsättningar

Feline biobank

Lohi, H. (Skapad av), University of Helsinki, 2017

Datauppsättning

Canine biobank

Lohi, H. (Skapad av), University of Helsinki, 2017

Datauppsättning

Priser

Helsingin kaupungin tiedepalkinto 2013

Hannes Lohi (!!Recipient), 6 jun 2013

Pris: Pris och hedersbetygelser

Aktiviteter 2008 2018

Opponent of doctoral dissertation

Hannes Lohi (Handledare)
24 aug 2018

Aktivitet: ExaminationstyperOpponent i doktorsavhandling

Terveydeksi: Koira tieteen palveluksessa

Hannes Lohi (!!Speaker)
27 okt 2017

Aktivitet: Typer för tal eller presentation!!Invited talk

Chair: Session 3: Neurology

Hannes Tapani Lohi (!!Speaker)
20 maj 201724 maj 2017

Aktivitet: Typer för tal eller presentation!!Invited talk

Argumenta

Hannes Lohi (Närvarande)
12 apr 2016

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

ACVIM 2016

Hannes Lohi (Närvarande)
7 jun 201612 jun 2016

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

Press / media

Uhkaako geenimuuntelu terveyttä?

Hannes Lohi

24/10/2018

1 mediabidrag

Press/media: !!Press / Media

Kaikkein paras kaveri

Hannes Lohi

08/07/2017

1 mediabidrag

Press/media: !!Press / Media

Kissojen terveyskartoitus

Hannes Lohi

21/09/2016

1 mediabidrag

Press/media: !!Press / Media

Koirien perinnölliset sairaudet ovat luultua yleisempiä

Hannes Lohi

18/08/2016

1 mediabidrag

Press/media: !!Press / Media

Koirien veritesti

Hannes Lohi

16/08/2016

1 mediabidrag

Press/media: !!Press / Media