Foto på Iiris Hovatta
  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

  • Finland

19942019
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Personlig profil

Information om forskning och undervisning

Research: Anxiety disorders are the most common mental disorders within the EU and cause considerable disability due to high prevalence (14 %), early onset and chronic nature. The major questions in anxiety disorders are which molecular events lead to and maintain pathological anxiety, and how this pathology can be normalized. We employ a multidisciplinary approach to understand the genetic and neurobiological basis of normal and pathological anxiety. Anxiety is an evolutionarily conserved response to a threatening situation and therefore mouse models can be used to study some aspects of anxiety. We are identifying gene regulatory networks, comprising of mRNAs and miRNAs that are dysregulated in various mouse models of anxiety-like behavior. We then investigate the molecular mechanisms that link these networks to the regulation of anxiety-like behavior using genetic and pharmacological tools, combined with behavioral analysis. Importantly, we further study the homologous human genes as candidate genes for human anxiety disorders. Understanding of the molecular mechanisms that regulate anxiety are likely to lead to the development of better targeted therapies for anxiety disorders.

Teaching: I am the Chair of Doctoral Program Brain & Mind since 2016. I am involved in teaching genetics, genomics, and behavioral neuroscience. I organize a B.Sc./M.Sc. level course Behavioral Genetics yearly during period 3, a Ph.D. level seminar series Big Questions in Neuroscience and Current Limits of Knowledge, and I co-organize the yearly Finnish Symposium on Biological Psychiatry.

Keywords

  • 1184 Genetik, utvecklingsbiologi, fysiologi
  • 3112 Neurovetenskaper
  • 3124 Neurologi och psykiatri

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1994 2019

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., Ellison, J. A., Schadt, E. E., Verma, I. M., Lockhart, D. J. & Barlow, C., 2005, I : Nature. 438, s. 662-666 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Assessment of the Neuropeptide S System in Anxiety Disorders

Donner, J., Haapakoski, R., Ezer, S., Melen, E., Pirkola, S., Gratacos, M., Zucchelli, M., Anedda, F., Johansson, L. E., Soderhall, C., Orsmark-Pietras, C., Suvisaari, J., Martin-Santos, R., Torrens, M., Silander, K., Terwilliger, J. D., Wickman, M., Pershagen, G., Lönnqvist, J., Peltonen, L. & 5 andraEstivill, X., D'Amato, M., Kere, J., Alenius, H. & Hovatta, I., 2010, I : Biological Psychiatry. 68, 5, s. 474-483 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Anxiety genetics-findings from cross-species genome-wide approaches

Sokolowska, E. & Hovatta, I., 2013, I : Biology of mood & anxiety disorders . 3, 9, 8 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis

Mantere, O., Trontti, K., Garcia-Gonzalez, J., Balcells, I., Saarnio, S., Mäntylä, T., Lindgren, M., Kieseppa, T., Raij, T., Honkanen, J. K., Vaarala, O., Hovatta, I. & Suvisaari, J., feb 2019, I : Journal of Psychiatric Research. 109, s. 18-26 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population

Sinha, V., Ukkola-Vuoti, L., Ortega-Alonso, A., Torniainen-Holm, M., Therman, S., Tuulio-Henriksson, A., Jylhä, P., Kaprio, J., Hovatta, I., Isometsä, E., Cannon, T. D., Lonnqvist, J., Paunio, T., Suvisaari, J. & Hennah, W., 2019, (!!Accepted/In press) I : Molecular Psychiatry. https://www.nature.com/articles/s41380-019-0429-x.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Priser

Duodecimin kirjoituspalkinto

Iiris Hovatta (!!Recipient), 2007

Pris: Pris och hedersbetygelser

Pro gradu -tutkielman hyvä ohjaaja -palkinto

Iiris Hovatta (!!Recipient), 2007

Pris: Pris och hedersbetygelser

Rosalind Franklin Young Investigator Award

Iiris Hovatta (!!Recipient), 2010

Pris: Pris och hedersbetygelser

Aktiviteter 1997 2017

The effect of homocysteine on telomere length

Zuzanna Misiewicz (Handledare), Iiris Maaria Hovatta (Handledare)
maj 2017

Aktivitet: ExaminationstyperHandledning av annat kunskapsprov (pro gradu, licentiatavhandling)

The 2nd Finnish Symposium of Biological Psychiatry, Finland

Zuzanna Misiewicz (Medlem i organisationskommitté), Iiris Maaria Hovatta (Medlem i organisationskommitté), Tiina Maria Paunio (Medlem i organisationskommitté)
19 dec 2016

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

Press / media

Alttiusgeenejä löytyy myös skitsofrenian ja autismin takaa

Iiris Hovatta

04/11/2009

1 mediabidrag

Press/media: !!Press / Media

Johtuuko ahdistuneisuus geeneistä

Iiris Hovatta

14/10/2009

1 mediabidrag

Press/media: !!Press / Media

Tutkiva juttu: Ahdistus

Iiris Hovatta

01/04/2008

1 mediabidrag

Press/media: !!Press / Media

Periytyykö paniikkihäiriö

Iiris Hovatta

01/01/2007

1 mediabidrag

Press/media: !!Press / Media