Foto av Jari Yli-Kauhaluoma
  • PL 56 (Viikinkaari 5)

    00014

    Finland

1986 …2021

Research output per year

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Personlig profil

Utbildning information

Research interests

Medicinal chemistry of

  • combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
  • chemical induction of cellular reprogramming and differentiation
  • targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
  • bioactive terpenes of marine and forest sources
  • novel synthesis methods of bioactive compounds

Topics of recent publications 

  • Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
  • Terpene-derived compounds as antileishmanial agents
  • Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
  • Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases

Teaching activities

  • Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus

Recent administrative duties

  • Vice Dean for Research, Faculty of Pharmacy, 2018-
  • Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
  • President of the Finnish Chemical Society, 2016-2018
  • Co-ordinator of the Marie Curie project PRINT-AID, 2017-
  • Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
  • Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
  • Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
  • Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015

Vetenskapsgrenar

  • 317 Farmaci
  • 116 Kemi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 jul 2015, I : European Journal of Medicinal Chemistry. 102, s. 68-79 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 jun 2015, I : Journal of Medicinal Chemistry. 58, 11, s. 4573-4580 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Pyrofosfaatti lääketieteessä

Goldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T., 2016, I : Duodecim. 132, 12, s. 1111-1117 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., feb 2016, I : Journal of Natural Products. 79, 2, s. 274-280 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., feb 2016, I : Journal of Natural Products. 79, 2, s. 362-368 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Projekter

Priser

Bioorganic and Medicinal Chemistry, one of the best reviewers

Jari Yli-Kauhaluoma (!!Recipient), 13 jan 2016

Pris: Pris och hedersbetygelser

Technical Research Centre of Finland (VTT) Award

Jari Yli-Kauhaluoma (!!Recipient), 1998

Pris: Pris och hedersbetygelser

The Albert Wuokko Award 2019

Jari Yli-Kauhaluoma (!!Recipient), 30 okt 2019

Pris: Pris och hedersbetygelser

Aktiviteter

Member of doctoral thesis committee: Biosynthesis of a family of UV-absorbing natural products, mycosporines

Jari Yli-Kauhaluoma (Medlem i avhandlingskommitté)
1 jan 202031 dec 2023

Aktivitet: ExaminationstyperMedlem i doktorsavhandlingskommitté

Journal of Medicinal Chemistry (Tidskrift)

Jari Yli-Kauhaluoma (Referentgranskare)
10 mar 2020

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Member of the Grading Committee: Ashkan Bonabi

Jari Yli-Kauhaluoma (Annan roll (beskriv i "Relationsbeskrivning"))
10 jan 2020

Aktivitet: ExaminationstyperMedlem i doktorsavhandlingskommitté

Journal of Medicinal Chemistry (Tidskrift)

Jari Yli-Kauhaluoma (Referentgranskare)
17 jan 2020

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Tidningsurklipp

2017 EuCheMS General Assembly, Rome, Italy

Jari Yli-Kauhaluoma

28/10/2017

1 Mediabidrag

Press/media: !!Press / Media

Komposti tuottaa antibiootteja

Jari Yli-Kauhaluoma & Päivi Pauliina Järvinen

19/05/2017

1 objekt av Mediabevakning

Press/media: !!Press / Media

Turun Sanomat: Jätteistä etsitään antibiootteja (Paikalliset, web)

Jari Yli-Kauhaluoma, Jouko Peltonen & Jawad Sarfraz

12/03/2017

1 Mediabidrag

Press/media: !!Press / Media

Turun Sanomat: Jätteistä etsitään antibiootteja (Tiede, print)

Jari Yli-Kauhaluoma, Jawad Sarfraz & Jouko Peltonen

12/03/2017

1 Mediabidrag

Press/media: !!Press / Media