Forskningsresultat per år
Personlig profil
Utbildning information
Research interests
Medicinal chemistry of
- combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
- chemical induction of cellular reprogramming and differentiation
- targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
- bioactive terpenes of marine and forest sources
- novel synthesis methods of bioactive compounds
Topics of recent publications
- Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
- Terpene-derived compounds as antileishmanial agents
- Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
- Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases
Teaching activities
- Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus
Recent administrative duties
- Vice Dean for Research, Faculty of Pharmacy, 2018-
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Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
- President of the Finnish Chemical Society, 2016-2018
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Co-ordinator of the Marie Curie project PRINT-AID, 2017-
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Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
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Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
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Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
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Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015
Vetenskapsgrenar
- 317 Farmaci
- 116 Kemi
Internationellt och inhemskt samarbete
Publikationer och projekt inom de senaste fem åren.
Publikationer
New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity
Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 jul 2015, I : European Journal of Medicinal Chemistry. 102, s. 68-79 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides
Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 jun 2015, I : Journal of Medicinal Chemistry. 58, 11, s. 4573-4580 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Pyrofosfaatti lääketieteessä
Goldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T., 2016, I : Duodecim. 132, 12, s. 1111-1117 7 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo
Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., feb 2016, I : Journal of Natural Products. 79, 2, s. 274-280 7 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi
Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., feb 2016, I : Journal of Natural Products. 79, 2, s. 362-368 7 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Projekter
Sustainable Drug Discovery and Development with End-of-Life Yield
Yli-Kauhaluoma, J., Sikanen, T., Äystö, L., Ahkola, H., Perkola, N., Karlsson, S., Pihlaja, T. & Järvinen, P.
01/03/2019 → 31/03/2021
Projekt: Forskningsprojekt
SUDDEN: Sustainable Drug Discovery and Development with End-of-life Yield
Yli-Kauhaluoma, J., Sikanen, T. & Xhaard, H.
01/11/2018 → 31/12/2021
Projekt: Forskningsprojekt
TWIN-A: Transforming waste into new antibiotics
Fallarero, A., Kontro, M. H., Peltonen, J., Sikanen, T., Vuorela, P. & Yli-Kauhaluoma, J.
01/01/2017 → 31/12/2020
Projekt: Forskningsprojekt
Generation Green
Sikanen, T., Yli-Kauhaluoma, J., Hirvonen, J., Vuorela, P., Kärkkäinen, R., Vuorensola, K., Teppo, J., Salminen, O., Sivula, S. & Teräsalmi, E.
01/01/2015 → …
Projekt: Annan projekt
Priser
Alfred Kordelinin yleinen edistys- ja sivistysrahasto: Tieteen palkinto 2015
Jari Yli-Kauhaluoma (!!Recipient), 6 nov 2015
Pris: Pris och hedersbetygelser
Bioorganic and Medicinal Chemistry, one of the best reviewers
Jari Yli-Kauhaluoma (!!Recipient), 13 jan 2016
Pris: Pris och hedersbetygelser
Medal of the Flemish Science Foundation, Fonds Wetenschappelijk Onderzoek – Vlaanderen (FWO)
Jari Yli-Kauhaluoma (!!Recipient), 12 sep 2014
Pris: Pris och hedersbetygelser
Technical Research Centre of Finland (VTT) Award
Jari Yli-Kauhaluoma (!!Recipient), 1998
Pris: Pris och hedersbetygelser
The Albert Wuokko Award 2019
Jari Yli-Kauhaluoma (!!Recipient), 30 okt 2019
Pris: Pris och hedersbetygelser
Aktiviteter
Member of doctoral thesis committee: Biosynthesis of a family of UV-absorbing natural products, mycosporines
Jari Yli-Kauhaluoma (Medlem i avhandlingskommitté)1 jan 2020 → 31 dec 2023
Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
Journal of Medicinal Chemistry (Tidskrift)
Jari Yli-Kauhaluoma (Referentgranskare)10 mar 2020
Aktivitet: Typer för peer review av output och redaktionsarbete › Referentgranskning av manuskript
Member of the Grading Committee: Ashkan Bonabi
Jari Yli-Kauhaluoma (Annan roll (beskriv i "Relationsbeskrivning"))10 jan 2020
Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
Journal of Medicinal Chemistry (Tidskrift)
Jari Yli-Kauhaluoma (Referentgranskare)17 jan 2020
Aktivitet: Typer för peer review av output och redaktionsarbete › Referentgranskning av manuskript
Member of doctoral thesis committee: New bioorthogonal radiolabeling strategies for tracking tumor infiltrating lymphocytes and their progeny in mouse models of metastatic melanoma
Jari Yli-Kauhaluoma (Medlem i avhandlingskommitté)18 mar 2020 → …
Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
Tidningsurklipp
Komposti tuottaa antibiootteja
Jari Yli-Kauhaluoma & Päivi Pauliina Järvinen
19/05/2017
1 objekt av Mediabevakning
Press/media: !!Press / Media
Turun Sanomat: Jätteistä etsitään antibiootteja (Paikalliset, web)
Jari Yli-Kauhaluoma, Jouko Peltonen & Jawad Sarfraz
12/03/2017
1 Mediabidrag
Press/media: !!Press / Media
Turun Sanomat: Jätteistä etsitään antibiootteja (Tiede, print)
Jari Yli-Kauhaluoma, Jawad Sarfraz & Jouko Peltonen
12/03/2017
1 Mediabidrag
Press/media: !!Press / Media
Report: EuCheMS:n yleiskokous (10.-11.9.2016, Sevilla, Espanja)
10/09/2016
1 Mediabidrag
Press/media: !!Press / Media