Personlig profil
Meritförteckning
Professor Jonathan K.C. Knowles
Visiting Professor, FIMM, HiLIFE, University of Helsinki, Finland
Visiting Professor, University of Oxford, U.K.
Professor Emeritus, EPFL, Switzerland
Professor Knowles was Head of Group Research and Member of the Executive Committee at Roche up to the end of 2009. He was a member of the Genentech Board for the last 12 years and a member of the Chugai Board for seven years. In this role he had oversight of an R&D budget of more than 8 Billion €. Prof. Knowles was also the chairman of the Corporate Governance Committee of Genentech. Under his leadership, the company developed and implemented a strategy of highly effective therapies based on personalized healthcare.
He was, for 5 years, the Chairman of the Research Directors’ Group of EFPIA (European Federation of Pharmaceutical Industry Associations) and was the first chairman of the Board of the Innovative Medicines Initiative, a unique public-private partnership between 28 Pharmaceutical companies and the European Commission with the participation of over 200 academic institutions in Europe with a budget of more than 5 Billion Euros over ten years.
Prior to this, he served as Director of the Glaxo Institute in Geneva for 10 years and as Head of European Research for Glaxo Wellcome.
Prof Knowles attended Magdalen College School in Oxford and received a First Class Honours Degree in Molecular Genetics from the University of East Anglia in Norwich, UK. He received his Ph.D. in Genetics of Mitochondria with Professor G. H. Beale F.R.S. from the University of Edinburgh in Scotland.
Jonathan Knowles held a Distinguished Professorship in Personalised medicine at FIMM (Institute for Molecular Medicine Finland) at the University of Helsinki 2010-2014 and his work at FIMM continues as Visiting Professor. Jonathan Knowles is also Visiting Professor at the University of Oxford, Member of the European Molecular Biology Organization, Professor Emeritus at EPFL, Lausanne and a visiting Scholar at Pembroke College, Cambridge.
In 2011, Jonathan Knowles was appointed as a Trustee of Cancer Research UK, one of the world’s leading Cancer Research Organisations and as Board member of A*Star, the leading state research organisation in Singapore. He is currently Chairman of Immunocore Ltd. and Adaptimmune Ltd, two leading UK Cancer Immunotherapy companies and serves as a non-executive member of a number of Biotech company boards and on the international scientific advisory boards of several Public Organisations.
In April 2015 Jonathan Knowles was named as the Personalized Medicine World Conference 2015 Honorary.
Vetenskapsgrenar
- 3111 Biomedicinska vetenskaper
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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML
Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T. & Wennerberg, K. & 2 andra, , 10 aug. 2017, I: Blood. 130, 6, s. 789-802 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 juni 2014, I: Scientific Reports. 4, 10 s., 5193.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia
Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L. & Mattila, P. & 16 andra, , dec. 2013, I: Cancer Discovery. 3, 12, s. 1416-1429 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Identification of Personalized Therapeutic Strategies and Associated Biomarkers in Adult Acute Myeloid Leukemia Using a Functional Drug Sensitivity and Resistance Testing Platform
Pemovska, T., Yadav, B., Kulesskiy, E., Kontro, M., Heckman, C., Knowles, J., Porkka, K., Aittokallio, T., Kallioniemi, O. & Wennerberg, K., nov. 2012, I: European Journal of Cancer. 48, s. 142-143 2 s.Forskningsoutput: Tidskriftsbidrag › Mötesabstrakt › Peer review
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Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K. & Parsons, A. & 9 andra, , 2012, I: New England Journal of Medicine. 366, 20, s. 1905-1913 9 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Aktiviteter
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SLUSH: MedTrack keynote, introduction to the personalized medicine (past-present-future)
Knowles, J. (Talare: Inledningsanförande (keynote))
12 nov. 2015Aktivitet: Typer för deltagande i eller organisering av evenemang › Public Talks
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Aalto University (Extern organisation)
Knowles, J. (Assessment)
2015Aktivitet: Medlemskapstyper › Utlåtanden vid tillsättning
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SITRA's GetPersonalized! -summit
Knowles, J. (Närvarande)
25 maj 2015Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
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EATRIS Finland launch event
Knowles, J. (Närvarande)
11 mars 2015Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
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Building Bridges Symposium
Knowles, J. (Talare: Ordförande)
6 okt. 2015Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
Tidningsurklipp
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Interview: Owal Group, for Tekes and AoF (FiDiPro programme evaluation on impact of the programme)
10/04/2014
1 Mediabidrag
Press/media: !!Press / Media
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Interview for Sitra's publication on Direct-to-consumer genome data services and their business models
14/06/2013
1 Mediabidrag
Press/media: !!Press / Media
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