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Our group is interested in how neuronal diversity is generated during embryonic development. In particular, we study the mechanisms of intercellular communication and gene regulation, which control neuronal differentiation in a distinct region of the vertebrate brain - the midbrain.
The midbrain contains neurons, such as dopaminergic and GABAergic neurons, which control several aspects of behavior, are involved in psychiatric disease and are targets of medical treatments as well as drugs of abuse. However, their molecular diversity and regulation of their development from neuroepithelial stem cells are poorly understood. We are addressing these questions using a combination of genetic and molecular approaches.
Vetenskapsgrenar
- 1184 Genetik, utvecklingsbiologi, fysiologi
- 3112 Neurovetenskaper
Internationellt och inhemskt samarbete
Publikationer och projekt inom de senaste fem åren.
Publikationer 1990 2018
A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions
Nikkanen, J., Landoni, J. C., Balboa, D., Haugas, M., Partanen, J., Paetau, A., Isohanni, P., Brilhante, V. & Suomalainen, A., jan 2018, I : EMBO molecular medicine. 10, 1, s. 13-21 9 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 nov 2018, I : eLife. 7, 35 s., 38519.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool
Zega, K., Jovanovic, V. M., Vitic, Z., Niedzielska, M., Knaapi, L., Jukic, M. M., Partanen, J., Friedel, R. F., Lang, R. & Brodski, C., 9 nov 2017, I : Frontiers in Molecular Neuroscience. 10, 15 s., 372.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Inactivation of GATA cofactors Fog1 and Fog2 impairs the development of midbrain GABAergic neurons
Tikker, L., Lahti, L. S., Estartús, N. & Partanen, J. M., jul 2017, s. S94. 1 s.Forskningsoutput: Konferensbidrag › Sammanfattning › Forskning
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Melanoblast development coincides with the late emerging cells from the dorsal neural tube in turtle Trachemys scripta
Rice, R., Cebra-Thomas, J., Haugas, M., Partanen, J., Rice, D. P. C. & Gilbert, S. F., 21 sep 2017, I : Scientific Reports. 7, 11 s., 12063.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Priser
Aktiviteter 1999 2015
Examination of doctoral dissertation Jokinen
Juha Partanen (Förhandsgranskare)2015
Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling
Examination of doctoral dissertation Zarkada
Juha Partanen (Förhandsgranskare)2014
Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling
Examination of doctoral dissertation Hakanen
Juha Partanen (Förhandsgranskare)2014
Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling
Suomen kehitysbiologian seura (Extern organisation)
Juha Partanen (Ordförande)2013 → 2015
Aktivitet: Medlemskapstyper › Medlemskap eller annan roll i organ inom privat företag/organisation
Examination of doctoral dissertation Zheng
Juha Partanen (Förhandsgranskare)2013
Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling