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Personlig profil

Information om forskning och undervisning

Cell surface glycoconjugates in cell interactions of the nervous system and in bacterial adhesion

Polysialic acid is a neurodevelopmental antigen shared by the neural cell adhesion molecule NCAM and capsular polysaccharides of meningitis-causing bacteria. Polysialic acid regulates cell interactions in neural and other tissues during development, and in learning and memory consolidation. Polysialic acid has a central role in many cellular functions, such as migration, cytokine response and cell contact-dependent differentiation. Altered levels of polysialic acid are detected in various neurological diseases, as well as malignancies including neuroblastoma. The objectives of the project are to elucidate the molecular basis of the regulation of polysialic acid expression and to investigate whether polysialic acid could be used as a target for cytotoxicity of neuroblastoma cells.

Meningitis-causing and other pathogenic bacteria attach to their tissue receptors by adhesin molecules binding to specific carbohydrate ligands on cell surfaces. Characterisation of these molecular interactions sheds light on the pathogenic mechanisms of bacterial diseases, and enables the development of new vaccines and new types of drugs that interfere with bacterial adhesion. We are studying carbohydrate-binding proteins to determine their interaction mechanisms and to develop inhibitors of adhesion that could be used as antibacterials.

See also Glycoscience Group

Utbildning information

MD University of Helsinki 1975
MScD University of Helsinki 1977

Utbildning / akademisk kvalifikation

Found qualified and competent for Professor of Biochemistry and Pharmaceutical Chemistry, Åbo Akademi, 1982

Found qualified and competent for Professor of Biochemistry, University of Turku, 1983

Found qualified and competent for Professor of Physiological Chemistry, University of Kuopio, 1985

Found qualified and competent for Professor of Medical Chemistry, University of Turku, 1986

Found qualified and competent for Professor of Glycobiology, University of Helsinki, 2007

Found qualified and competent for Professor of Cell and Molecular Biology, University of Helsinki, 2009

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi
  • 1183 Växtbiologi, mikrobiologi, virologi
  • 3111 Biomedicinska vetenskaper
  • 3112 Neurovetenskaper
  • 3122 Cancersjukdomar

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1974 2018

Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations

Haataja, S., Verma, P., Fu, O., Papageorgiou, A. C., Pöysti, S., Pieters, R. J., Nilsson, U. J. & Finne, J., 2018, I : Chemistry: A European Journal. 24, 8, s. 1905-1912 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

Lehti, T. A., Pajunen, M. I., Skog, M. S. & Finne, J., 4 dec 2017, I : Nature Communications. 8, 12 s., 1915.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells

Skog, M. S., Nystedt, J., Korhonen, M., Anderson, H., Lehti, T. A., Pajunen, M. I. & Finne, J., 2016, I : Stem Cell Research & Therapy. 7, 12 s., 113.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Endosialidases: Versatile tools for the study of polysialic acid

Jakobsson, E., Schwarzer, D., Jokilammi, A. & Finne, J., 2015, SialoGlyco Chemistry and Biology II : Tools and Techniques to Identify and Capture Sialoglycans. Gerardy-Schahn, R., Delannoy, P. & von Itzstein, M. (red.). Cham: Springer International Publishing AG, s. 29-73 45 s. (Topics in Current Chemistry; vol. 367).

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Projekter 2013 2016

Cytotoxic constructs targeting polysialic acid

Lehti, T., Skog, M., Lilie, H., Nacher, J. & Finne, J.

Projekt: Forskningsprojekt

Towards picomolar inhibitors of bacterial adhesion

Finne, J., Haataja, S., Nilsson, U. & Pieters, R.

Projekt: Forskningsprojekt

Role of polysialic acid in human neuroblastoma

Finne, J., Vettenranta, K., Sariola, H., Porkka, K. & Lehti, T.

Projekt: Forskningsprojekt

Aktiviteter 1978 2020

The Scientific Board of the University of Helsinki (Extern organisation)

Jukka Finne (Medlem)
20132014

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

The Finnish Society of Sciences and Letters (Extern organisation)

Jukka Finne (Medlem)
2010 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Societas Biophysica, Biochimica et Microbiologica Fenniae (Extern organisation)

Jukka Finne (Styrelsemedlem)
20102012

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Member of the Scientific Advisory Board of Sialoglyco 2020 Meeting, Gifu, Japan

Jukka Finne (Medlem av vetenskaplig kommitté)
2020

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

Member of the Board of the University Helsinki branch of the Finnish Union of University Professors

Jukka Finne (Deltagare)
2019

Aktivitet: Andra aktivitetstyperTyper av övriga aktiviteter - Övrigt

Press / media

Interviewed for an article in Acatiimi

Jukka Finne

01/01/2016

1 Mediabidrag

Press/media: !!Press / Media

Interviewed for an article in Yliopisto-lehti

Jukka Finne

01/01/2015

1 Mediabidrag

Press/media: !!Press / Media

Interviewed for an article in Teknia Journal

Jukka Finne

01/01/1995

1 Mediabidrag

Press/media: !!Press / Media

Interviewed for local news program in radio

Jukka Finne

01/01/1989

1 Mediabidrag

Press/media: !!Press / Media

Interviewed for local news program in radio

Jukka Finne

01/01/1988

1 Mediabidrag

Press/media: !!Press / Media