Foto på Kaarina Sivonen
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1982 …2022
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Personlig profil

Information om forskning och undervisning

Research Interests: Cyanobacteria, toxins and bioactive compounds

Principal investigator: Professor in Microbiology, Kaarina Sivonen

 

Cyanobacteria (blue-green algae) carry out oxygen evolving plant-like photosynthesis and are thus important for the survival of life on Earth through the production of oxygen and sequestration of carbon dioxide. In aquatic environment they may form harmful toxic mass occurrences which pose a serious health hazard for animals and human beings. Some of them are also able to fix nitrogen and form symbioses (e.g. lichens). Cyanobacteria are prolific source of biomedically interesting bioactive compounds.

The cyanobacteria research group found toxic mass occurrences of cyanobacteria to be common in Finnish lakes and in the Baltic Sea, isolated the toxin producing cyanobacteria, investigated toxin production and identified the toxins. Toxic and non-toxic cyanobacteria cannot be differentiated by microscopy and we have developed molecular methods to detect producers of toxins and odorous metabolites.

Cyanobacteria are prolific source of interesting bioactive compounds. We have identified number of novel bioactive compounds (toxins, bioactive compounds having cytotoxic, enzyme inhibiting and antifungal and antibacterial properties) from strains in our culture collection and genome projects have revealed number of new biosynthetic pathways. Bioactive compounds are synthetized by both ribosomal and non-ribosomal pathways in cyanobacteria. We have sequenced number of cyanobacteria and used genome mining to identify the biosynthetic pathways for cyanobacterial natural products. We use physiological experiments, field studies and post genomic analyses of toxic and bloom forming cyanobacteria to study the ecology of these organisms.

Key facilities in our research are the culture collection of cyanobacteria (UHCC part of HAMBI collection) and mass spectrometry and NMR facilities of the University of Helsinki. By chemical analysis methods we can quantitate the toxin and bioactive compounds, purify the compounds and solve the structures of unknown new compounds.  We have also found promising hydrogen producers from our culture collection.

 

Research group belonged to the Finnish Research Center of Excellence in Integrative Photosynthesis and Bioactive Compound Research at Systems Biology Level (2008-2013).

Members of the research group:
Docent Jouni Jokelapost-doc Danillo Alvarenga, Ph D students Anu Humisto, Julia Österholm, Lassi Heinilä and Rafael Popin, technical assistants Maria Christodoulou, Sila Arsin and Anna Jortikka

More information:
Cyanobacteria Group
Photobiomics 

 

Keywords

  • 1183 Växtbiologi, mikrobiologi, virologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1982 2019

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

Mares, J., Hajek, J., Urajova, P., Kust, A., Jokela, J., Saurav, K., Galica, T., Capkova, K., Mattila, A., Haapaniemi, E., Permi, P., Mysterud, I., Skulberg, O. M., Karlsen, J., Fewer, D. P., Sivonen, K., Tonnesen, H. H. & Hrouzek, P., feb 2019, I : Applied and Environmental Microbiology. 85, 4, 17 s., UNSP e02675-18.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes.

Humisto, A., Jokela, J., Teigen, K., Wahlsten, M., Permi, P., Sivonen, K. & Herfindal, L., 1 aug 2019, I : Biochimica et Biophysica Acta. Biomembranes. 1861, s. 1510-1521 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Effects of allochthonous DOM input on microbial composition and nitrogen cycling genes at two contrasting estuarine sites

Happel, E. M., Trine, M., Teikari, J., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Middelboe, M., Kisand, V. & Riemann, L., 2019, (!!Accepted/In press) I : FEMS Microbiology Ecology.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Frequency of virus-resistant hosts determines experimental community dynamics.

Coloma, S. E., Gaedge, U., Sivonen, A. K. & Hiltunen, T. J., jan 2019, I : Ecology. s. 1-9 9 s., ECY2554.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Insight into the genome and brackish water adaptation strategies of toxic and bloom-forming Baltic Sea Dolichospermum sp. UHCC 0315

Teikari, J., Vicentini Popin, R., Hou, S., Wahlsten, M., Hess, W. R. & Sivonen, K., 20 mar 2019, I : Scientific Reports. 9, 13 s., 4888.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Projekter 2000 2022

Aktiviteter 1995 2019

11th International Conference on Toxic Cyanobacteria.

Kaarina Sivonen (Medlem i organisationskommitté)
5 maj 201910 maj 2019

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

K. Sivonen acted as custos and chair of evaluation committee of the Ph D thesis by Tania Quirin

Kaarina Sivonen (Medlem i avhandlingskommitté)
27 jun 2019

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling