Foto på Kalle Saksela
  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

  • PL 21 (Haartmaninkatu 3), E354

    HELSINGIN YLIOPISTO

    Finland

  • Finland

1984 …2019
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Personlig profil

Meritförteckning

Kalle M. Saksela

     Born September 10, 1962 in Philadelphia, PA, USA.

Education:

        MD, 1989 (University of Helsinki)

        PhD, 1989 (University of Helsinki)           

Professional history:

2005- Professor of Virology and Chairman of Department of Virology,

    University of Helsinki.

2005- Chief Physician, HUSLAB, Helsinki University Hospital.

1996-2005: Professor of Molecular Medicine. Institute for Medical Technology.

    University of Tampere. Finland.

1996-2000 Adjunct Professor associated with the laboratory of James Darnell Jr.

    The Rockefeller University, New York.

1994-1996 Assistant Professor. The Rockefeller University, New York.

1991-1994: Postdoctoral Fellow with David Baltimore at the Rockefeller University,

    New York.

1991-1991: Postdoctoral Fellow with David Baltimore at the Whitehead

    Institute for Biomedical Research, Cambridge, MA.

1989-1990: Research Fellow, Department of Virology, University of Helsinki.

1984-1989: MD/PhD student with Kari Alitalo at the Department of Virology,

    University of Helsinki

Information om forskning och undervisning

The HIV Nef protein has been a key subject of our research, Nef modifies host cell physiology to better support viral replication by binding to proteins involved in cellular signal structures via their SH3 domains. SH3 domains are the most ubiquitous class of modular protein binding units found in the nature. SH3 domains mediate many key regulatory processes in normal cells and are involved the pathomechanisms of many important diseases. It appears that many other viral proteins also share the capacity of Nef to utilize binding to host cell SH3 proteins in order to mediate their functions. Identification of normal SH3-mediated cellular protein interaction networks as well as SH3-interactions that take place between cellular and pathogenic viral proteins, and elucidation of the molecular basis of binding affinity and specificity involved in these interactions are the main topics goals of our research.

Key topics:

- Virus-host cell interplay

- Protein interactions

- SH3 domains

- miRNA and viruses

- Viral non-structural proteins

- Protein engineering

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper
  • 311 Basmedicin

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1984 2019

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA

Ylösmäki, E., Hakkarainen, T., Hemminki, A., Visakorpi, T., Andino, R. & Saksela, K., 2008, I : Journal of Virology. 82, 22, s. 11009-11015 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling

Heikkinen, L. S., Kazlauskas, A., Melen, K., Wagner, R., Ziegler, T., Julkunen, I. & Saksela, K., 2008, I : Journal of Biological Chemistry. 283, 9, s. 5719-5727 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

Vingadassalom, D., Kazlauskas, A., Skehan, B., Cheng, H-C., Magoun, L., Robbins, D., Rosen, M. K., Saksela, K. & Leong, J. M., 2009, I : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, s. 6754-6759 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

Kärkkäinen, S., Hiipakka, M., Wang, J-H., Kleino, I., Vähä-Jaakkola, M., Renkema, G. H., Liss, M., Wagner, R. & Saksela, K., 2006, I : EMBO Reports. 7, 2, s. 186-191 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

Aitio, O., Hellman, M., Kazlauskas, A., Vingadassalom, D. F., Leong, J. M., Saksela, K. & Permi, P., 2010, I : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, s. 21743-21748 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Priser

Aaron Diamond Foundation Junior Faculty Award

Kalle Saksela (!!Recipient), 1994

Pris: Pris och hedersbetygelser

Anders Jahre award for a younger medical researcher

Kalle Saksela (!!Recipient), 2002

Pris: Pris och hedersbetygelser

Member of the Finnish Academy of Science and Letters

Kalle Saksela (!!Recipient), 2003

Pris: Pris och hedersbetygelser

Aktiviteter 2005 2011

Univeristy of Helsinki (Extern organisation)

Kalle Saksela (Medlem)
2007 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i inhemskt/internationellt offentligt organ

University of Helsinki (Extern organisation)

Kalle Saksela (Medlem)
2010 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i inhemskt/internationellt offentligt organ

University of Helsinki (Extern organisation)

Kalle Saksela (Medlem)
2009 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i inhemskt/internationellt offentligt organ

Kyoto University

Kalle Saksela (Annan roll)
7 mar 201110 mar 2011

Aktivitet: Typer för besök till extern institutionAkademisk besök på annan institution

Ongoing PhD supervision - Contanze Schmotz

Kalle Saksela (Handledare)
2011 → …

Aktivitet: ExaminationstyperHandledare eller bihandledare av doktorsavhandling

Press / media

Tv-uutiset (News)

Kalle Saksela

21/05/2010

1 Mediabidrag

Press/media: !!Press / Media

Interview, Yle: Tiede ja tekniikka

Kalle Saksela

01/01/2010

1 Mediabidrag

Press/media: !!Press / Media