Foto på Kari Keinänen
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20002019
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Personlig profil

Information om forskning och undervisning

RESEARCH in my laboratory focuses on AMPA receptors, tetrameric ion channels that mediate glutamate signaling in the brain and other tissues. AMPA receptors are important regulators of the efficiency of synaptic transmission, a key property underlying learning and memory, and contribute - when malfunctioning - to numerous neuropathologies. We are using a combination of biochemical, molecular biological and electrophysiological methods to study the mechanisms which determine the subunit composition, cellular localization and protein interactions of AMPA receptors in order to understand their function in normal and diseased brain in molecular detail. 

Current topics:

1. Cytosolic protein interactions of long-tailed AMPA receptor subunits GluA1 and GluA4

2. Modulation of AMPA receptor function by interacting proteins

3. Quality control of AMPA receptor trafficking

 

 

Vetenskapsgrenar

  • 118 Biovetenskaper
  • 1182 Biokemi, cell- och molekylärbiologi
  • 318 Medicinsk bioteknologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 2000 2019

  • 36 Artikel
  • 1 Konferensbidrag
  • 1 Översiktsartikel

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

von Ossowski, L., Li, L-L., Möykkynen, T., Coleman, S. K., Courtney, M. J. & Keinänen, K., 2 feb 2017, I : PLoS One. 12, 2, 15 s., 0171489.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Aggregation Limits Surface Expression of Homomeric GluA3 Receptors

Coleman, S. K., Hou, Y., Willibald, M., Semenov, A., Möykkynen, T. & Keinänen, K., 15 apr 2016, I : Journal of Biological Chemistry. 291, 16, s. 8784-8794 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

The N-terminal Domain Modulates alpha-Amino-3-hydroxy-5methyl-4-isoxazolepropionic acid ( AMPA) Receptor Desensitization

Moykkynen, T., Coleman, S. K., Semenov, A. & Keinanen, K., 9 maj 2014, I : Journal of Biological Chemistry. 289, 19, s. 13197-13205 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors

Luchkina, N. V., Huupponen, J., Clarke, V. R. J., Coleman, S. K., Keinanen, K., Taira, T. & Lauri, S. E., 2014, I : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, s. 4321-4326 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome

Danesi, C. E., Keinänen, K. P. & Castren, M. L., 8 feb 2019, I : Frontiers in Synaptic Neuroscience. 11, 8 s., 2.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

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Projekter 2013 2017

Aktiviteter 2017 2017

  • 1 Medlem i doktorsavhandlingskommitté

Doctoral Thesis Committee Member (8 students)

Kari Keinänen (Medlem i avhandlingskommitté)
1 jan 2017 → …

Aktivitet: ExaminationstyperMedlem i doktorsavhandlingskommitté