Research:

• Principal topics: Mechanisms of steroid hormone action, inherited disorders of cholesterol metabolism, molecular genetics of severe cardiac arrhythmias, genetic mechanisms underlying human hypertension
• Over 300 scientific articles, supervised 17 theses
• Awards: Lauri Saxen Award 1999, Matti Äyräpää Award 2005

Teaching:

• Teacher at the University of Helsinki since 1972
• Instructor, clinical teacher, associate professor, professor
• Dean of the Faculty of Medicine 2007-2009, Vice-Rector 2010-2013
• Awards and honors: Lecturer of the Year of the Faculty of Medicine 1995, Teaching Person of the Year of the Faculty of Medicine 2010

Clinical activities:

• Clinician at the Department of Internal Medicine of the Helsinki University Central Hospital (HUCH) since 1978
• At present: Chief Physician (adjunct position) at HUCH, consulting in diagnostics and treatment of patients with resistant hypertension

Societal interactions:

• Previous activities: Chairman of the Duodecim Society, Editor-in-Chief of the Duodecim Journal, Chairman of the Board of the Finnish Cultural Foundation, Inspector of the Students´ Nation of the Southern Finland, Chairman of the Boards for FIMM (Institute for Molecular Medicine in Finland), Palmenia and UniSport
• At present (2014-): Member of the Board of the University of Helsinki, Chairman of the Board of Yrjö Jahnsson Foundation, Member of the Board of Paavo Nurmi Foundation