20102019
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Personlig profil

Information om forskning och undervisning

My research interests include different advanced drug delivery systems, especially nanoscale systems enabling intracellular delivery of drugs. I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug with exposition to light and change in pH after cell uptake. These light triggerable and pH-sensitive liposomes would enable time- and site-controlled drug delivery, thus allowing refined treatment regimens and reducing drug exposition of non-target cells. Drug delivery via these stimuli-responsive liposomes would provide improved delivery methods for the treatment of, for instance, diseases of the posterior eye (such as age-related macular degeneration and diabetic retinopathy) that currently need to be treated with frequent, invasive intravitreal injections.

Vetenskapsgrenar

  • 317 Farmaci

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 2010 2019

Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., apr 2019, I : Cell Transplantation. 28, 4, s. 413-424 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells in a three-dimensional environment

Salonius, E., Kontturi, L., Laitinen, A., Haaparanta, A-M., Korhonen, M., Nystedt, J., Kiviranta, I. & Muhonen, V., 25 sep 2019, I : Journal of Cellular Physiology. 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Light-Triggered Cellular Delivery of Oligonucleotides

Kontturi, L-S., van den Dikkenberg, J., Urtti, A., Hennink, W. E. & Mastrobattista, E., feb 2019, I : Pharmaceutics. 11, 2, 16 s., 90.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release

Lajunen, T., Kontturi, L-S., Viitala, L., Manna, M., Cramariuc, O., Rog, T., Bunker, A., Laaksonen, T., Viitala, T., Murtomäki, L. & Urtti, A., jun 2016, I : Molecular Pharmaceutics. 13, 6, s. 2095-2107 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Light activated liposomes: Functionality and prospects in ocular drug delivery

Lajunen, T., Nurmi, R., Kontturi, L., Viitala, L., Yliperttula, M., Murtomaki, L. & Urtti, A., 28 dec 2016, I : Journal of Controlled Release. 244, s. 157-166 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Aktiviteter 2013 2015

  • 1 Medlem i doktorsavhandlingskommitté
  • 1 Akademisk besök på annan institution

Utrecht University, Department of Pharmaceutical Sciences

Leena Kontturi (Besökande forskare)
1 nov 201531 dec 2016

Aktivitet: Typer för besök till extern institutionAkademisk besök på annan institution

Member of doctoral thesis committee

Yan-Ru Lou (Medlem i avhandlingskommitté)
22 maj 2013

Aktivitet: ExaminationstyperMedlem i doktorsavhandlingskommitté