Forskningsresultat per år
Forskningsresultat per år
Personlig profil
Forskningsintressen
Maciej Maurycy Lalowski is affilitiated to Medicum, Department of Biochemistry and Developmental Biology, Meilahti Clinical Proteomics Core Facility, HiLIFE, University of Helsinki. Maciej does research in Proteomics, Neurodegeneration and Mass Spectrometry Imaging. The current research projects relate to the role of microglia in neurodegeneration (UniH, Helsinki) and rare forms of diabetes (AMU-Poznan, PL).
Utbildning information
MSc degree (1991), graduated with distinction/Faculty of Biology, University of Warsaw, Poland, scope biochemistry
1991-1992: Postgraduate studies, graduated with distinction
Faculty of Geography, Institute of Developing Countries, University of Warsaw
PhD degree (1997), graduated with distinction
Polish Academy of Sciences, Warsaw-Poland /joint research at NYU Medical Center, Dept. of Pathology, NYC, USA (1992-1996)
Docent (2011): University of Helsinki, Faculty of Medicine, scope medical biochemistry
Doctor habilitated (doktor habilitowany) (2021) Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan
Title: "Systematic studies on protein interactions and affected disease pathways underlying neuronal ceroid lipofuscinosis" (15.07.2021)
Utbildning / akademisk kvalifikation
Biological sciences, Doctor of Science (Doctor habilitated), Systematic studies on protein interactions and affected disease pathways underlying Neuronal Ceroid Lipofuscinosis, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan
20 nov. 2020 → 15 juli 2021
Tilldelningsdatum: 15 juli 2021
Alzheimer's Disease/aging, Doctor of Philosophy, Characterization of Amyloid Beta peptides and associated factors in Alzheimer's Disease and aging brain, Medical Research Center, Polish Academy of Sciences
1 mars 1992 → 1 dec. 1997
Tilldelningsdatum: 1 dec. 1997
Externa befattningar
AMU professor, Adam Mickiewicz University, Institute of Molecular Biology and Biotechnology, Department of Gene Expression
14 feb. 2025 → …
Visiting professor, Adam Mickiewicz University, Institute of Molecular Biology and Biotechnology, Department of Gene Expression
1 nov. 2022 → 31 okt. 2024
Adjunct, Institute of Bioorganic Chemistry, Polish Academy of Science, Poznan-Poland
3 aug. 2020 → 31 juli 2021
Vetenskapsgrenar
- 3111 Biomedicinska vetenskaper
- 1182 Biokemi, cell- och molekylärbiologi
- 3112 Neurovetenskaper
- 318 Medicinsk bioteknologi
Internationellt och inhemskt samarbete
Publikationer och projekt inom de senaste fem åren.
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CLN5 deficiency impairs glucose uptake in Batten disease.
Marchese, M., Bernardi, S., Vivarelli, R., Doccini, S., Santucci, L., Ogi, A., Licitra, R., Zang, J., Soliymani, R., Mero, S., Neuhauss, S. C., Signore, G., Lalowski, M. & Santorelli, F. M., 2 jan. 2025, I: bioRxiv : the preprint server for biology . 2025.01.02, 630719Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig
Öppen tillgångFil -
Molecular puzzle of insulin: structural assembly pathways and their role in diabetes
Urbaniak, E., Henry, S., Lalowski, M. & Borowiak, M., 20 feb. 2025, I: Frontiers in Cell and Developmental Biology. 13, 14 s., 1502469.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review
Öppen tillgångFil -
The lipidome and proteome of high-density lipoprotein are altered in menopause.
Lehti, S., Korhonen, T.-M., Soliymani, R., Ruhanen, H., Lähteenmäki, E., Palviainen, M., Siljander, P., Lalowski, M., Käkelä, R., Lehti, M. & Laakkonen, E. K., 11 jan. 2025, (BioRxiv beta : the preprint server for biology).Forskningsoutput: Arbetsdokument › Förtryck
Öppen tillgångFil -
USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells
Srinivasan, V., Soliymani, R., Ivanova, L., Eriksson, O., Peitsaro, N., Lalowski, M., Karelson, M. & Lindholm, D., 2025, I: Heliyon. 11, 3, 22 s., e42031.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
Scordino, M., Stepanova, P., Srinivasan, V., Pham Duc, D., Eriksson, O., Lalowski, M., Mudo, G., Di Liberto, V., Korhonen, L. & Lindholm, D., 18 sep. 2024, I: Frontiers in Molecular Neuroscience. 17, 14 s., 1473058.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil
Projekter
- 4 Slutfört
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MicroSynDep: Microglial control of synaptic function in stress response and vulnerability to depression
Lalowski, M. (Projektledare)
01/10/2018 → 31/10/2022
Projekt: Forskningsprojekt
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SZ_TEST: Towards Early Molecular Diagnostics of Schizophrenia
Lalowski, M. (Deltagare)
01/01/2017 → 31/12/2020
Projekt: Forskningsprojekt
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H2020 RISE project SZ_TEST
Lindholm, D. B. (Projektledare), Lalowski, M. (Principal Investigator), Vaheri, A. (Projektledare), Tienari, P. (Projektledare) & Korhonen, L. (Principal Investigator)
01/01/2017 → 31/12/2020
Projekt: Forskningsprojekt
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Prop-AD: PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier.
Lalowski, M. (Projektledare)
01/10/2016 → 31/08/2019
Projekt: Forskningsprojekt
Aktiviteter
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Diagnostic and prognostic role of expressed KRAS and BRAF mutations in MAPK/ERK-driven cancers
Lalowski, M. (Annan roll (beskriv i "Relationsbeskrivning")), Stenman, J. (Handledare), Orpana, A. (Bihandledare), Ho, T. H. (Handledare), Gunarsson, U. (Opponent), Elenius, K. (Förhandsgranskare) & Mäkinen, M. (Förhandsgranskare)
21 juni 2021Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling
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Platelet-derived extracellular vesicle subpopulations in health and disease
Lalowski, M. (Medlem i avhandlingskommitté)
1 jan. 2021 → 31 dec. 2025Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
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Regression plane concept for analysing continuous cellular processes with machine learning
Lalowski, M. (Medlem i avhandlingskommitté)
1 apr. 2021 → 31 dec. 2025Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
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Spring Proteomics Highlights
Lalowski, M. (Talare: Ordförande)
14 apr. 2021Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
Fil -
Systemwide function of ORP7 in human endothelial cells
Lalowski, M. (Medlem i avhandlingskommitté)
1 maj 2020 → 30 apr. 2023Aktivitet: Examinationstyper › Medlem i doktorsavhandlingskommitté
Tidningsurklipp
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A potential treatment for cardiac regeneration
30/06/2020
3 objekt av Mediabevakning
Press/media: !!Press / Media
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Researchers have found a promising therapy for cardiac regeneration
30/06/2020
5 objekt av Mediabevakning
Press/media: !!Press / Media
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'Multiomics' and the newborn mouse heart
01/06/2018 → 04/06/2018
3 objekt av Mediabevakning
Press/media: !!Press / Media
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Researchers use 'multiomics' approach to study newborn mouse heart
04/06/2018
1 objekt av Mediabevakning
Press/media: !!Press / Media
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'Multiomics' and the newborn mouse heart - New insights into the development of heart disease therapeutics
Lalowski, M., Lakkisto, P., Kankuri, E. & Baumann, M.
01/06/2018
1 objekt av Mediabevakning
Press/media: !!Press / Media