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  • Viikinkaari 5

    HELSINKI

    Finland

  • PL 56 (Viikinkaari 5)

    00014

    Finland

1985 …2019
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Publikationer 1985 2019

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1985

ACUTE MYELOGENOUS LEUKEMIA WITH C-MYC AMPLIFICATION AND DOUBLE MINUTE CHROMOSOMES

ALITALO, K., WINQVIST, R., KESKIOJA, J., ILVONEN, M., SAKSELA, K., ALITALO, R., LAIHO, M., KNUUTILA, S. & DELACHAPELLE, A., 1985, I : Lancet. 2, s. 1035-1039 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

REGULATION OF PLASMINOGEN-ACTIVATOR ACTIVITY IN HUMAN FIBROBLASTIC CELLS BY FIBRO-SARCOMA CELL-DERIVED FACTORS

SAKSELA, O., LAIHO, M. & KESKIOJA, J., 1985, I : Cancer Research. 45, s. 2314-2319 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1986

CHARACTERIZATION OF A NOVEL GELATIN-BINDING 21 KDA PROTEIN SECRETED BY CULTURED ADHERENT CELLS

KESKIOJA, J., LAIHO, M. & VARTIO, T., 1986, I : Biochimica et Biophysica Acta. 882, s. 367-376 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

ENHANCED PRODUCTION AND EXTRACELLULAR DEPOSITION OF THE ENDOTHELIAL-TYPE PLASMINOGEN-ACTIVATOR INHIBITOR IN CULTURED HUMAN-LUNG FIBROBLASTS BY TRANSFORMING GROWTH-FACTOR-BETA

LAIHO, M., SAKSELA, O., ANDREASEN, P. A. & KESKIOJA, J., 1986, I : Journal of Cell Biology. 103, s. 2403-2410 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TRANSFORMING GROWTH-FACTOR-BETA ALTERS PLASMINOGEN-ACTIVATOR ACTIVITY IN HUMAN-SKIN FIBROBLASTS

LAIHO, M., SAKSELA, O. & KESKIOJA, J., 1986, I : Experimental Cell Research. 164, s. 399-407 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1987

TRANSFORMING GROWTH-FACTOR-BETA IS A STRONG AND FAST ACTING POSITIVE REGULATOR OF THE LEVEL OF TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR MESSENGER-RNA IN WI-38 HUMAN-LUNG FIBROBLASTS

LUND, L. R., RICCIO, A., ANDREASEN, P. A., NIELSEN, L. S., KRISTENSEN, P., LAIHO, M., SAKSELA, O., BLASI, F. & DANO, K., 1987, I : EMBO Journal. 6, s. 1281-1286 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1990

CELL-CELL ADHESION MEDIATED BY BINDING OF MEMBRANE-ANCHORED TRANSFORMING GROWTH FACTOR-ALPHA TO EPIDERMAL GROWTH-FACTOR RECEPTORS PROMOTES CELL-PROLIFERATION

ANKLESARIA, P., TEIXIDO, J., LAIHO, M., PIERCE, J. H., GREENBERGER, J. S. & MASSAGUE, J., 1990, I : Proceedings of the National Academy of Sciences of the United States of America. 87, s. 3289-3293 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

CONCOMITANT LOSS OF TRANSFORMING GROWTH-FACTOR (TGF)-BETA RECEPTOR TYPE-I AND TYPE-II IN TGF-BETA-RESISTANT CELL MUTANTS IMPLICATES BOTH RECEPTOR TYPES IN SIGNAL TRANSDUCTION

LAIHO, M., WEIS, F. M. B. & MASSAGUE, J., 1990, I : Journal of Biological Chemistry. 265, s. 18518-18524 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

DISTINCT TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) RECEPTOR SUBSETS AS DETERMINANTS OF CELLULAR RESPONSIVENESS TO 3 TGF-BETA ISOFORMS

CHEIFETZ, S., HERNANDEZ, H., LAIHO, M., TENDIJKE, P., IWATA, K. K. & MASSAGUE, J., 1990, I : Journal of Biological Chemistry. 265, s. 20533-20538 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

GROWTH-INHIBITION BY TGF-BETA LINKED TO SUPPRESSION OF RETINOBLASTOMA PROTEIN-PHOSPHORYLATION

LAIHO, M., DECAPRIO, J. A., LUDLOW, J. W., LIVINGSTON, D. M. & MASSAGUE, J., 1990, I : Cell. 62, s. 175-185 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1991

CONTROL OF JUNB AND EXTRACELLULAR-MATRIX PROTEIN EXPRESSION BY TRANSFORMING GROWTH FACTOR-BETA-1 IS INDEPENDENT OF SIMIAN VIRUS-40 T-ANTIGEN-SENSITIVE GROWTH-INHIBITORY EVENTS

LAIHO, M., RONNSTRAND, L., HEINO, J., DECAPRIO, J. A., LUDLOW, J. W., LIVINGSTON, D. M. & MASSAGUE, J., 1991, I : Molecular and Cellular Biology. 11, s. 972-978 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

EARLY GENE RESPONSES TO TRANSFORMING GROWTH-FACTOR-BETA IN CELLS LACKING GROWTH-SUPPRESSIVE RB FUNCTION

ZENTELLA, A., WEIS, F. M. B., RALPH, D. A., LAIHO, M. & MASSAGUE, J., 1991, I : Molecular and Cellular Biology. 11, s. 4952-4958 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

RESPONSIVENESS TO TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) RESTORED BY GENETIC COMPLEMENTATION BETWEEN CELLS DEFECTIVE IN TGF-BETA RECEPTOR-I AND RECEPTOR-II

LAIHO, M., WEIS, F. M. B., BOYD, F. T., IGNOTZ, R. A. & MASSAGUE, J., 1991, I : Journal of Biological Chemistry. 266, s. 9108-9112 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1992

TGF-BETA SIGNALS THROUGH A HETEROMERIC PROTEIN-KINASE RECEPTOR COMPLEX

WRANA, J. L., ATTISANO, L., CARCAMO, J., ZENTELLA, A., DOODY, J., LAIHO, M., WANG, X. F. & MASSAGUE, J., 1992, I : Cell. 71, s. 1003-1014 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1993

EXPRESSION OF THE HUMAN RETINOBLASTOMA GENE-PRODUCT IN MOUSE FIBROBLASTS - EFFECTS ON CELL-PROLIFERATION AND SUSCEPTIBILITY TO TRANSFORMATION

PITKANEN, K., KIVINEN, L., DECAPRIO, J. A. & LAIHO, M., 1993, I : Experimental Cell Research. 207, s. 99-106 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

HUMAN RETINOBLASTOMA GENE-PRODUCT PREVENTS C-HA-RAS ONCOGENE-MEDIATED CELLULAR-TRANSFORMATION OF MOUSE FIBROBLASTS

KIVINEN, L., PITKANEN, K. & LAIHO, M., 1993, I : Oncogene. 8, s. 2703-2711 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1995

CELL-CYCLE DEPENDENT EFFECTS OF UV-RADIATION ON P53 EXPRESSION AND RETINOBLASTOMA PROTEIN-PHOSPHORYLATION

HAAPAJARVI, T., KIVINEN, L., PITKANEN, K. & LAIHO, M., 1995, I : Oncogene. 11, s. 151-159 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1996

p21(ras)-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanisms

Kivinen, L., Tiihonen, E., Haapajarvi, T. & Laiho, M., 1996, I : Cell Growth & Differentiation . 7, s. 1705-1712 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1997

Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor

Tsubari, M., Tiihonen, E. & Laiho, M., 1997, I : Cancer Research. 57, s. 2966-2973 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

Enholm, B., Paavonen, K., Ristimaki, A., Kumar, V., Gunji, Y., Klefström, J., Kivinen, L., Laiho, M., Olofsson, B., Joukov, V., Eriksson, U. & Alitalo, K., 1997, I : Oncogene. 14, s. 2475-2483 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

Haapajarvi, T., Pitkanen, K., Tsubari, M. & Laiho, M., 1997, I : Molecular and Cellular Biology. 17, s. 3074-3080 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1998

UVC-induction of p53 activation and accumulation is dependent on cell cycle and pathways involving protein synthesis and phosphorylation

Pitkanen, K., Haapajarvi, T. & Laiho, M., 1998, I : Oncogene. 16, s. 459-469 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1999

Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta 1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity

Tsubari, M., Taipale, J., Tiihonen, E., Keski-Oja, J. & Laiho, M., 1999, I : Molecular and Cellular Biology. 19, s. 3654-3663 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Human melanoma cell line UV responses show independency of p53 function

Haapajarvi, T., Pitkanen, K. & Laiho, M., 1999, I : Cell Growth & Differentiation . 10, s. 163-171 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Ras induces p21(Cip1/Waf1) cyclin kinase inhibitor transcriptionally through Sp1-binding sites

Kivinen, L., Tsubari, M., Haapajarvi, T., Datto, M. B., Wang, X. F. & Laiho, M., 1999, I : Oncogene. 18, s. 6252-6261 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner

Haapajarvi, T., Kivinen, L., Heiskanen, A., des Bordes, C., Datto, M. B., Wang, X. F. & Laiho, M., 1999, I : Experimental Cell Research. 248, s. 272-279 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2000

Accumulation of a form of p27(Kip1) not associated with Cdk-cyclin complexes in transforming growth factor-p-arrested Mv1Lu cells

Taipale, M., Tiihonen, E., Heiskanen, A. & Laiho, M., 2000, I : Experimental Cell Research. 259, s. 107-116 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2001

Ectopic expression of Cdk6 circumvents transforming growth factor-beta mediated growth inhibition

Zhang, F., Taipale, M., Heiskanen, A. & Laiho, M., 2001, I : Oncogene. 20, s. 5888-5896 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

Latonen, L., Taya, Y. & Laiho, M., 2001, I : Oncogene. 20, s. 6784-6793 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2002

Proteasomal activity modulates TGF-beta signaling in a gene-specific manner

Zhang, F., Monkkonen, M., Roth, S. & Laiho, M., 2002, I : FEBS Letters. 527, s. 58-62 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Buzek, J., Latonen, L., Kurki, S., Peltonen, K. & Laiho, M., 2002, I : Nucleic Acids Research. 30, s. 2340-2348 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TGF-beta induced G(1) cell cycle arrest requires the activity of the proteasome pathway

Zhang, F., Monkkonen, M., Roth, S. & Laiho, M., 2002, I : Experimental Cell Research. 281, s. 190-196 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2003

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses

Gentile, M., Latonen, L. & Laiho, M., 2003, I : Nucleic Acids Research. 31, s. 4779-4790 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

Kurki, S., Latonen, L. & Laiho, M., 2003, I : Journal of Cell Science. 116, s. 3917-3925 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

On and off: proteasome and TGF-beta signaling

Zhang, F. & Laiho, M., 2003, I : Experimental Cell Research. 291, s. 275-281 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

Latonen, L., Kurki, S., Pitkanen, K. & Laiho, M., 2003, I : Cellular Signalling. 15, s. 95-102 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2005

Cellular UV damage responses: functions of tumor suppressor p53

Latonen, L. & Laiho, M., 2005, I : Biochimica et Biophysica Acta. Reviews on Cancer. 1775, 2, s. 71-89 19 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

FGF-2 blocks TGF-[beta]1-mediated suppression of Bcl-2 in normal melanocytes

Willebrand, M. V., Köhler, K., Alanko, T., Laiho, M. & Saksela, O., 2005, I : Experimental Dermatology. 14, 3, s. 202-208 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis

Peltonen, K., Kiviharju, T. M., Järvinen, P. M., Ra, R. & Laiho, M., 2005, I : Pigment cell research. 18, 3, s. 196-202 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21(Cip1) pathway

Vaque, J. P., Navascues, J., Shiio, Y., Laiho, M., Ajenjo, N., Mauleon, I., Matallanas, D., Crespo, P. & Leon, J., 2005, I : Journal of Biological Chemistry. 280, s. 1112-1122 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway

Vaque, J. P., Navascues, J., Shiio, Y., Laiho, M., Ajenjo, N., Mauleon, I., Matallanas, D., Crespo, P. & Leon, J., 2005, I : Journal of Biological Chemistry. 280, 2, s. 1112-1122 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2007

Eturauhassyöpäalttiuden taustalla DNA-vauriovasteen puuttuminen: [Proc Natl Acad Sci USA in press]

Kiviharju-af Hällström, T. M., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M. & Laiho, M., 2007, I : Duodecim. 123, 9, s. 1019-1020 2 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskaplig

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

Kiviharju-af Hällström, T. M., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M. & Laiho, M., 2007, I : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, s. 7211-7216 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., 2007, I : Journal of Neuroscience. 27, 6, s. 1434-1444 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p19[sup Ink4d] and p21[sup Cip1] collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., 2007, I : Journal of Neuroscience. 27, 6, s. 1434-1444 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p53-kasvurajoitereitin aktivaatio - uusi mahdollisuus virusperäisen lymfooman hoitoon: [J Clin Invest in press]

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P. M., 2007, I : Duodecim. 123, 8, s. 869-870 2 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskaplig