Marja Mikkola

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19972018
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Publikationer 1997 2018

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Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9 -/- Mice

Jia, S., Zhou, J., Wee, Y., Mikkola, M. L., Schneider, P. & D'Souza, R. N., okt 2017, I : Journal of Dental Research. 96, 11, s. 1282-1289 8 s.

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Biological activity of ectodysplasin A is conditioned by Its collagen and heparan sulfate proteoglycan-binding domains

Swee, L. K., Ingold-Salamin, K., Tardivel, A., Willen, L., Gaide, O., Favre, M., Demotz, S., Mikkola, M. & Schneider, P., 2009, I : Journal of Biological Chemistry. 284, 40, s. 27567-27576 10 s.

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Development of ectodermal organs

Thesleff, I. & Mikkola, M. L., 2014, I : Seminars in Cell and Developmental Biology. 25-26, s. 1-2 2 s.

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Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis

Ahtiainen, L., Lefebvre, S., Lindfors, P. H., Renvoise, E., Shirokova, V., Vartiainen, M. K., Thesleff, I. & Mikkola, M. L., 10 mar 2014, I : Developmental Cell. 28, 5, s. 588-602 15 s.

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Early epithelial signaling center governs tooth budding morphogenesis

Ahtiainen, L., Uski, I., Thesleff, I. & Mikkola, M. L., 12 sep 2016, I : Journal of Cell Biology. 214, 6, s. 753-767 15 s.

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Early inductive events in ectodermal appendage morphogenesis

Biggs, L. C. & Mikkola, M. L., 2014, I : Seminars in Cell and Developmental Biology. 25-26, s. 11-21 11 s.

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Ectodysplasin/NF-kappa B Promotes Mammary Cell Fate via Wnt/beta-catenin Pathway

Voutilainen, M., Lindfors, P., Trela, E., Lönnblad, D., Shirokova, V., Elo, T., Rysti, E., Schmidt-Ullrich, R., Schneider, P. & Mikkola, M. L., nov 2015, I : PLoS Genetics. 11, 11, 26 s., 1005676.

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Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia

Podzus, J., Kowalczyk-Quintas, C., Schuepbach-Mallepell, S., Willen, L., Staehlin, G., Vigolo, M., Tardivel, A., Headon, D., Kirby, N., Mikkola, M., Schneider, H. & Schneider, P., feb 2017, I : Journal of Dental Research. 96, 2, s. 217-224 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis

Häärä, O., Fujimori, S., Schmidt-Ullrich, R., Hartmann, C., Thesleff, I. & Mikkola, M. L., 2011, I : Child Development. 138, 13, s. 2681-2691 11 s.

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Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression

Pummila, M., Fliniaux, I., Jaatinen, R., James, M. J., Laurikkala, J., Schneider, P., Thesleff, I. & Mikkola, M. L., 2007, I : Development. 134, s. 117-125 9 s.

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Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein

Elomaa, O., Pulkkinen, K., Hannelius, U., Mikkola, M., Saarialho-Kere, U. & Kere, J., 2001, I : Human Molecular Genetics. 2001, 10, s. 953-962 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling

Häärä, O., Harjunmaa, E., Lindfors (o.s. Hiltunen), P., Huh, S-H., Fliniaux, I. J. J., Åberg, T., Jernvall, J., Ornitz, D. M., Mikkola, M. & Thesleff, I., 25 jul 2012, I : Development. 139, 17, s. 3189-3199 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB

Voutilainen, M., Lindfors, P., Lefebvre, S., Ahtiainen, L., Fliniaux, I., Rysti, E., Murtoniemi, M., Schneider, P., Schmidt-Ullrich, R. & Mikkola, M. L., 10 apr 2012, I : Proceedings of the National Academy of Sciences of the United States of America. 109, 15, s. 5744-5749 6 s.

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Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

Elo, T., Lindfors, P. H., Lan, Q., Voutilainen, M., Trela, E., Ohlsson, C., Huh, S-H., Ornitz, D. M., Poutanen, M., Howard, B. A. & Mikkola, M. L., 11 jul 2017, I : Scientific Reports. 7, 13 s., 5049.

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Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development

Pispa, J., Pummila, M., Barker, P. A., Thesleff, I. & Mikkola, M. L., 2008, I : Human Molecular Genetics. 17, 21, s. 3380-3391 12 s.

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Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

Shirokova, V., Jussila, M., Hytönen, M. K., Perälä, N., Droegemueller, C., Leeb, T., Lohi, H., Sainio, K., Thesleff, I. & Mikkola, M. L., jun 2013, I : Developmental Dynamics. 242, 6, s. 593-603 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles

Huh, S-H., Närhi, K., Lindfors, P., Häärä, O., Yang, L., Ornitz, D. M. & Mikkola, M. L., 2013, I : Genes & Development. 27, 4, s. 450-458 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen, Cohen, I., Kumar, V., Xu, Z., Bar, C., Dauber-Decker, K. L., Tsai, P-C., Marangoni, P., Klein, O. D., Hsu, Y-C., Chen, T., Mikkola, M. L. & Ezhkova, E., 13 jun 2018, I : Nature Communications. 9, 10 s., 2333.

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Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation

Shirokova, V., Biggs, L. C., Jussila, M., Ohyama, T., Groves, A. K. & Mikkola, M. L., jul 2016, I : Stem Cells. 34, 7, s. 1896-1908 13 s.

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Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

Biggs, L. C., Mäkelä, O. J. M., Myllymäki, S-M., Das Roy, R., Närhi, K., Pispa, J., Mustonen, T. & Mikkola, M. L., 31 jul 2018, I : eLife. 7, 33 s., 36468.

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Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation

Murgiano, L., Shirokova, V., Welle, M. M., Jagannathan, V., Plattet, P., Oevermann, A., Pienkowska-Schelling, A., Gallo, D., Gentile, A., Mikkola, M. & Drögemüller, C., jul 2015, I : PLoS Genetics. 11, 7, 22 s., 1005427.

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Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes

Fliniaux, I., Mikkola, M. L., Lefebvre, S. & Thesleff, I., 2008, I : Developmental Biology. 320, 1, s. 60-71 12 s.

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Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

Lefebvre, S., Fliniaux, I., Schneider, P. & Mikkola, M. L., apr 2012, I : Journal of Investigative Dermatology. 132, 4, s. 1094-1102 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth

Nieminen, P. T., Morgan, N. V., Fenwick, A. L., Parmanen, S., Veistinen, L., Mikkola, M. L., van der Spek, P. J., Giraud, A., Judd, L., Arte, S., Brueton, L. A., Wall, S. A., Mathijssen, I. M. J., Maher, E. R., Wilkie, A. O. M., Kreiborg, S. & Thesleff, I., 2011, I : American Journal of Human Genetics. 89, s. 67-81 15 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Lippens, S., Lefebvre, S., Gilbert, S., Sze, M., Devos, M., Verhelst, K., Vereecke, L., Guire, CM., Guérin, C., Vandenabeele, P., Paspariks, M., Mikkola, M., Beyaert, R., Declercq, W. & van Loo, G., 2011, I : Cell Death and Differentiation. 18, s. 1845-1853 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Monoclonal antibodies specific for Semliki Forest virus replicase protein nsP2

Kujala, P., Rikkonen, M., Ahola, T., Kelve, M., Saarma, M. & Kaariainen, L., feb 1997, I : Journal of General Virology. 78, s. 343-351 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens

Speroni, L., Voutilainen, M., Mikkola, M. L., Klager, S. A., Schaeberle, C. M., Sonnenschein, C. & Soto, A. M., 19 jan 2017, I : Scientific Reports. 7, 7 s., 40806.

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On the difficulty of increasing dental complexity

Harjunmaa, E., Kallonen, A., Voutilainen, M., Hämäläinen, K., Mikkola, M. L. & Jernvall, J., 2012, I : Nature. 483, 7389, s. 324-328 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

Laurikkala, J., Mikkola, M. L., James, M., Tummers, M., Mills, A. A. & Thesleff, I., 2006, I : Development. 133, s. 1553-1563 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Protocol: Ex Vivo Culture of Mouse Embryonic Mammary Buds

Voutilainen, M., Lindfors, P. & Mikkola, M. L., jun 2013, I : Journal of Mammary Gland Biology and Neoplasia. 18, 2, s. 239-245 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Reciprocal requirements for EDA/EDAR/NF-B and Wnt/ß-catenin signaling pthways in hair follicle induction

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E. & Schmidt-Ullrich, R., 2009, I : Developmental Cell. 17, 1, s. 49-61 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Reciprocal Requirements for EDA/EDAR/NF-kappa B and Wnt/beta-Catenin Signaling Pathways in Hair Follicle Induction

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E. & Schmidt-Ullrich, R., 21 jul 2009, I : Developmental Cell. 17, 1, s. 49-61 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.

Laurikkala, J., Pispa, J. M., Jung, H. S., Nieminen, P. T., Mikkola, M., Wang, X-P., Saarialho-Kere, U., Galceran, J., Grosschedl, R. & Thesleff, I., 2002, I : Development. 129, s. 2541-2553 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Replaying evolutionary transitions from the dental fossil record

Harjunmaa, E., Seidel, K., Hakkinen, T., Renvoise, E., Corfe, I. J., Kallonen, A., Zhang, Z-Q., Evans, A. R., Mikkola, M. L., Salazar Ciudad, I., Klein, O. D. & Jernvall, J., 7 aug 2014, I : Nature. 512, 7512, s. 44- 16 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sostdc1 defines the size and number of skin appendage placodes

Närhi, K., Tummers, M., Ahtiainen, L., Itoh, N., Thesleff, I. & Mikkola, M. L., 15 apr 2012, I : Developmental Biology. 364, 2, s. 149-161 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning

Jussila, M., Aalto, A. J., Sanz Navarro, M., Shirokova, V., Balic, A., Kallonen, A., Ohyama, T., Groves, A. K., Mikkola, M. L. & Thesleff, I., 15 nov 2015, I : Development. 142, 22, s. 3954-3963 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation

Narhi, K., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L. & Thesleff, I., 15 mar 2008, I : Development. 135, 6, s. 1019-1028 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sustained epithelial ß-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation

Närhi, K., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L. & Thesleff, I., 2008, I : Development. 135, 6, s. 1019-1028 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

Rouleau, M., Medawar, A., Hamon, L., Shivtiel, S., Wolchinsky, Z., Zhou, H., De Rosa, L., Candi, E., de la Forest Divonne, S., Mikkola, M. L., van Bokhoven, H., Missero, C., Melino, G., Puceat, M. & Aberdam, D., 2011, I : International Journal of Stem Cells . 29, 11, s. 1672-1683 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

Srivastava, A. K., Pispa, J., Hartung, A. J., Du, Y. Z., Ezer, S., Jenks, T., Shimada, T., Pekkanen, M., Mikkola, M. L., Ko, M. S. H., Thesleff, I., Kere, J. & Schlessinger, D., 1997, I : Proceedings of the National Academy of Sciences of the United States of America. 94, s. 13069-13074 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis

Laurikkala, J., Mikkola, M., Mustonen, T., Åberg, T., Koppinen, P., Pispa, J. M., Nieminen, P. T., Galceran, J., Grosschedl, R. & Thesleff, I., 2001, I : BMC Developmental Biology. 229, s. 443-455 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Treasure or artifact: a decade of p63 research speaks for itself

Mikkola, M. L., Costanzo, A., Thesleff, I., Roop, D. R. & Koster, M. I., 2010, I : Cell Death and Differentiation. 17, 1, s. 180-183 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review