Foto av Mark Daly
  • PL 20 (Tukholmankatu 8)

    00014

    Finland

20082020

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Personlig profil

Meritförteckning

Mark Daly, Ph.D. is the Director of the Institute of Molecular Medicine Finland FIMM, where he succeeds Academy Professor Jaakko Kaprio as of February 1, 2018.  Mark was recruited from Harvard Medical School – where he was the founding chief of the Analytic and Translational Unit at the Massachusetts General Hospital from 2011 - and the Broad Institute of MIT and Harvard.

While primarily based in Finland, he retains an active role in Boston at HMS/MGH and as an Institute Member at the Broad Institute, where he is establishing a close partnership between FIMM and the Broad Institute.

Mark’s primary research focus is discovery of genes involved in human disease as a means of providing both insights for therapeutic development as well as improved diagnostics for individual patients.  His lab has developed many foundational computational tools and statistical techniques in genome mapping, linkage and association, and automated interpretation of laboratory data.  The lab has a significant and longstanding commitment in two major medical areas: the inflammatory bowel diseases (Crohn’s and ulcerative colitis) and neuropsychiatric disease (autism and schizophrenia) and Mark has led international consortium efforts large-scale gene mapping efforts in each of these areas – co-chairing the International IBD Genetics Consortium (https://www.ibdgenetics.org), the Psychiatric Genomics Consortium (pgc.unc.edu) and the Autism Sequencing Consortium. With Dr. Palotie, he has helped design and launch the FinnGen Project (www.finngen.fi) as a transformative public-private partnership.  Mark Daly has been an author on more than 450 peer-reviewed manuscripts with a total of more than 200,000 citations, has an h-index of 178, and has been listed by Thompson ISI/Science Watch in 2008 and 2010 as one of the top ten authors ranked by number of high-impact papers.  Mark was the recipient of the Curt Stern Award from the American Society of Human Genetics in 2014 and was elected to the National Academy of Medicine in 2017.

 

Vetenskapsgrenar

  • 112 Statistik
  • 1184 Genetik, utvecklingsbiologi, fysiologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

Emdin, C. A., Haas, M. E., Khera, A. V., Aragam, K., Chaffin, M., Klarin, D., Hindy, G., Jiang, L., Wei, W-Q., Feng, Q., Karjalainen, J., Havulinna, A., Kiiskinen, T., Bick, A., Ardissino, D., Wilson, J. G., Schunkert, H., McPherson, R., Watkins, H., Elosua, R. & 22 andra, Bown, M. J., Samani, N. J., Baber, U., Erdmann, J., Gupta, N., Danesh, J., Saleheen, D., Chang, K-M., Vujkovic, M., Voight, B., Damrauer, S., Lynch, J., Kaplan, D., Serper, M., Tsao, P., Program, M. V., Mercader, J., Hanis, C., Daly, M., Denny, J., Gabriel, S. & Kathiresan, S., 13 apr 2020, I : PLoS Genetics. 16, 4, 16 s., 1008629.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects

Epi25 Collaborative, Niestroj, L-M., Perez-Palma, E., Howrigan, D. P., Saarentaus, E., Daly, M. J., Palotie, A. & Lal, D., jul 2020, I : Brain : a journal of neurology. 143, s. 2106-2118 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Gene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders

EuroEPINOMICS- RES Consortium, Lal, D., May, P., Perez-Palma, E., Kurki, M., Palotie, A. & Daly, M. J., 17 mar 2020, I : Genome medicine. 12, 1, 12 s., 28.

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GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Zhou, W., Brumpton, B., Kabil, O., Gudmundsson, J., Thorleifsson, G., Weinstock, J., Zawistowski, M., Nielsen, J. B., Chaker, L., Medici, M., Teumer, A., Naitza, S., Sanna, S., Schultheiss, U. T., Cappola, A., Karjalainen, J., Kurki, M., Oneka, M., Taylor, P., Fritsche, L. G. & 36 andra, Graham, S. E., Wolford, B. N., Overton, W., Rasheed, H., Haug, E. B., Gabrielsen, M. E., Skogholt, A. H., Surakka, I., Smith, G. D., Pandit, A., Roychowdhury, T., Hornsby, W. E., Jonasson, J. G., Senter, L., Liyanarachchi, S., Ringel, M. D., Xu, L., Kiemeney, L. A., He, H., Netea-Maier, R. T., Mayordomo, J., Plantinga, T. S., Hrafnkelsson, J., Hjartarson, H., Sturgis, E. M., Palotie, A., Daly, M., Citterio, C. E., Arvan, P., Brummett, C. M., Boehnke, M., de la Chapelle, A., Stefansson, K., Hveem, K., Willer, C. J. & Asvold, B. O., 7 aug 2020, I : Nature Communications. 11, 1, 13 s., 3981.

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Identification of pathogenic variant enriched regions across genes and gene families

Perez-Palma, E., May, P., Iqbal, S., Niestroj, L-M., Du, J., Heyne, H. O., Castrillon, J. A., O'Donnell-Luria, A., Nuernberg, P., Palotie, A., Daly, M. & Lal, D., jan 2020, I : Genome Research. 30, 1, s. 62-71 10 s.

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Priser

Honorary doctorate at Aarhus University, Faculty of Health

Daly, Mark (!!Recipient), 13 sep 2019

Pris: Pris och hedersbetygelser

Aktiviteter

  • 28 !!Invited talk
  • 19 Akademiskt besök på HU
  • 4 Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
  • 1 Akademisk besök på annan institution

Beryl Cummings

Mark Daly (Värd)

11 aug 201915 aug 2019

Aktivitet: Typer för att vara värd för en besökareAkademiskt besök på HU

Talk: What can we achieve together - FinnGen as the first example

Mark Daly (!!Speaker)

12 apr 2019

Aktivitet: Typer för tal eller presentation!!Invited talk

Angela Belcher

Mark Daly (Värd)

5 sep 20199 sep 2019

Aktivitet: Typer för att vara värd för en besökareAkademiskt besök på HU

Talk: Beyond GWAS: Next steps in human genetics of complex traits

Mark Daly (!!Invited speaker)

28 maj 2019

Aktivitet: Typer för tal eller presentation!!Invited talk

Talk: EMBL Nordic Partnership Meeting

Mark Daly (!!Speaker)

26 sep 2019

Aktivitet: Typer för tal eller presentation!!Invited talk

Tidningsurklipp

Interview by Yliopistolehti

Mark Daly

09/01/2020

1 objekt av Mediabevakning

Press/media: !!Press / Media

Genome Research in Finland is cracking the code.

Mark Daly

07/01/2020

1 objekt av Mediabevakning

Press/media: !!Press / Media

Finnische Gene, eine Goldmine

Mark Daly

12/06/2019

1 objekt av Mediabevakning

Press/media: !!Press / Media