Foto av Matjaz Barboric
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

19992019

Research output per year

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Personlig profil

Information om forskning och undervisning

Controlling Transcription Elongation by RNA polymerase II: mechanisms, disease and development

We are investigating the fundamental mechanisms of metazoan gene transcription by RNA polymerase II (RNAPII). In particular, we are studying the regulatory factors that modulate RNAPII transcription at the level of elongation, which has been recognized only recently as a major rate-limiting step in gene expression. Our work is focused mainly on the key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of the biggest subunit of RNAPII, Rbp1, at serine 2 (Ser2-P CTD). By using biochemistry, genetics and the tools of systems biology, we are aiming to understand mechanisms that enable the function of elongation kinases as well as biological processes that are controlled by them. Because transcription elongation can be intimately connected to pre-mRNA processing in the course of transcription via Ser2-P CTD, we are also studying how elongation kinases affect mRNA maturation events such as alternative splicing. Of note, an important aspect of our work is to uncover how deregulation of RNAPII elongation control contributes to the onset of deadly diseases, including cancer. Finally, revealing the significance of transcription elongation kinases in embryonic development remains a pressing issue in our research group.

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

Bugai, A., Quaresma, A. J. C., Friedel, C. C., Lenasi, T., Düster, R., Sibley, C. R., Fuginaga, K., Kukanja, P., Hennig, T., Blasius, M., Geyer, M., Ule, J., Dölken, L. & Barboric, M., 18 apr 2019, I : Molecular Cell. 74, 2, s. 254-+ 24 s.

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Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

Christiano Quaresma, A. J., Bugai, A. & Barboric, M., 19 sep 2016, I : Nucleic Acids Research. 44, 16, s. 7527-7539 13 s.

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Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Anastasina, M., Le May, N., Bugai, A., Fu, Y., Soderholm, S., Gaelings, L., Ohman, T., Tynell, J., Kyttanen, S., Barboric, M., Nyman, T. A., Matikainen, S., Julkunen, I., Butcher, S. J., Egly, J-M. & Kainov, D. E., nov 2016, I : Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. 1859, 11, s. 1440-1448 9 s.

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The two sides of Tat

Barboric, M. & Fujinaga, K., 19 jan 2016, I : eLife. 5, 3 s., 12686.

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Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Ekumi, K., Paculova, H., Lenasi, T., Pospichalova, V., Boesken, C. A., Rybarikova, J., Bryja, V., Geyer, M., Blazek, D. & Barboric, M., 11 mar 2015, I : Nucleic Acids Research. 43, 5, s. 2575-2589 15 s.

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Projekter

Sigrid Juseliuksen Säätiö/Barboric Matjaz 2011

Barboric, M.

Unknown funder

01/06/201130/04/2014

Projekt: Forskningsprojekt

Aktiviteter

  • 1 Förhandsgranskare av doktorsavhandling

Regulation of Pol II polymerase transcriptional reponse to DNA-damage by RBM7 and P-TEFb

Robert Fisher (Opponent), Maciej Lalowski (Annan roll (beskriv i "Relationsbeskrivning")), Matjaz Barboric (Handledare), Dan Bj Lindholm (Handledare), Lea Sistonen (Förhandsgranskare), Minna Kaikkonen-Määttä (Förhandsgranskare)
22 jan 2020

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling