Foto av Moshe Finel

Moshe Finel

  • PL 56 (Viikinkaari 5)

    00014

    Finland

1983 …2020

Forskningsoutput per år

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Publikationer

2020

An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems

Zhu, Y-D., Pang, H-L., Zhou, Q-H., Qin, Z-F., Jin, Q., Finel, M., Wang, Y-N., Qin, W-W., Lu, Y., Wang, D-D. & Ge, G-B., jun 2020, I : Journal of Pharmaceutical Analysis. 10, 3, s. 263-270 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Human Efflux Transport of Testosterone, Epitestosterone and Other Androgen Glucuronides

Järvinen, E., Kidron, H. & Finel, M., mar 2020, I : Journal of Steroid Biochemistry and Molecular Biology. 197, 9 s., 105518.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T. & Finel, M., 1 jan 2020, I : European Journal of Pharmaceutical Sciences. 141, 9 s., 105118.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2019

A novel pathogenic UGT1A1 variant in a Sudanese child with type 1 Crigler-Najjar syndrome

Elfar, W., Järvinen, E., Weizhen, J. I., Mosorin, J., Sega, A. G., Iuga, A. C., Lobritto, S. J., Konstantino, M., Chan, A., Finel, M. & Lakhani, S. A., 1 jan 2019, I : Drug Metabolism and Disposition. 47, 1, s. 45-48 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Case report by Toce and co-authors: Have all the reasons for poor morphine glucuronidation been addressed?

Finel, M. & Järvinen, E., apr 2019, I : British Journal of Clinical Pharmacology. 85, 4, s. 859-860 2 s.

Forskningsoutput: TidskriftsbidragBrevVetenskaplig

Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3

Gotoh-Saito, S., Abe, T., Furukawa, Y., Oda, S., Yokoi, T., Finel, M., Hatakeyama, M., Fukami, T. & Nakajima, M., aug 2019, I : Drug Metabolism and Pharmacokinetics. 34, 4, s. 280-286 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling

Skledar, D. G., Trontelj, J., Troberg, J., Tomašič, T., Zega, A., Finel, M. & Mašič, L. P., feb 2019, I : Data in Brief. 22, s. 977-986 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Efflux transport of nicotine, cotinine and trans-3 '-hydroxycotinine glucuronides by human hepatic transporters

Jarvinen, E., Sjöstedt, N., Koenderink, J. B., Kidron, H. & Finel, M., dec 2019, I : Basic & Clinical Pharmacology & Toxicology. 125, 6, s. 490-498 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite

Skledar, D. G., Carino, A., Trontelj, J., Troberg, J., Distrutti, E., Marchiano, S., Tornasic, T., Zega, A., Finel, M., Fiorucci, S. & Maisic, L. P., jan 2019, I : Chemosphere. 215, s. 870-880 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism

Song, Y-Q., Weng, Z-M., Dou, T-Y., Finel, M., Wang, Y-Q., Ding, L-L., Jin, Q., Wang, D-D., Fang, S-Q., Cao, Y-F., Hou, J. & Ge, G-B., 1 aug 2019, I : Chemico-Biological Interactions. 308, s. 339-349 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Inhibition of UGT1A1 by natural and synthetic flavonoids

Liu, X-Y., Lv, X., Wang, P., Ai, C-Z., Zhou, Q-H., Finel, M., Fan, B., Cao, Y-F., Tang, H. & Ge, G-B., 1 apr 2019, I : International Journal of Biological Macromolecules. 126, s. 653 – 661 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, R. O., Novak, F., Emmanouilidou, E., Auriola, S., Timonen, J., Heikkinen, A. T., Küblbeck, J., Finel, M. & Raunio, H., apr 2019, I : Planta Medica. 85, 6, s. 453-464 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

Lv, X., Xia, Y., Finel, M., Wu, J., Ge, G. & Yang, L., mar 2019, I : Acta pharmaceutica sinica b. 9, 2, s. 258-278 21 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

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2018

Efflux transport of estrogen glucuronides by human MRP2, MRP3, MRP4 and BCRP

Järvinen, E., Deng, F., Kidron, H. & Finel, M., apr 2018, I : Journal of Steroid Biochemistry and Molecular Biology. 178, s. 99-107 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation

He, G., Troberg, J., Lv, X., Xia, Y-L., Zhu, L-L., Ning, J., Ge, G-B., Finel, M. & Yang, L., 2018, I : Xenobiotica. 48, 2, s. 109-116 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10

Juvonen, R. O., Rauhamäki, S., Kortet, S., Niinivehmas, S., Troberg, J., Petsalo, A., Huuskonen, J., Raunio, H., Finel, M. & Pentikäinen, O. T., mar 2018, I : Molecular Pharmaceutics. 15, 3, s. 923-933 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2017

Bisphenol AF: Does bisphenol AF glucuronide have endocrine activity?

Skledar, D. G., Carino, A., Trontelj, J., Finel, M., Troberg, J., Fiorucci, S. & Masic, L. P., 20 okt 2017, I : Toxicology Letters. 280, s. S111-S111 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskning

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

Street, C. M., Zhu, Z., Finel, M. & Court, M. H., 2017, I : Xenobiotica. 47, 1, s. 1-10 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?

Troberg, J., Järvinen, E., Ge, G-B., Yang, L. & Finel, M., sep 2017, I : Molecular Pharmaceutics. 14, 9, s. 2875-2883 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2016

Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae

Ikushiro, S., Nishikawa, M., Masuyama, Y., Shouji, T., Fujii, M., Hamada, M., Nakajima, N., Finel, M., Yasuda, K., Kamakura, M. & Sakaki, T., jul 2016, I : Molecular Pharmaceutics. 13, 7, s. 2274-2282 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Influence of metabolism on endocrine activities of bisphenol S

Skledar, D. G., Schmidt, J., Fic, A., Klopcic, I., Trontelj, J., Dolenc, M. S., Finel, M. & Masic, L. P., aug 2016, I : Chemosphere. 157, s. 152-159 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2015

An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications

Lv, X., Ge, G-B., Feng, L., Troberg, J., Hu, L-H., Hou, J., Cheng, H-L., Wang, P., Liu, Z-M., Finel, M., Cui, J-N. & Yang, L., 15 okt 2015, I : Biosensors & Bioelectronics. 72, s. 261-267 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure

Fowler, S., Kletzl, H., Finel, M., Manevski, N., Schmid, P., Tuerck, D., Norcross, R. D., Hoener, M. C., Spleiss, O. & Iglesias, V. A., feb 2015, I : Journal of Pharmacology and Experimental Therapeutics. 352, 2, s. 358-367 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10

Skledar, D. G., Troberg, J., Lavdas, J., Masic, L. P. & Finel, M., jun 2015, I : Xenobiotica. 45, 6, s. 511-519 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity

Troberg, J., Järvinen, E., Muniz, M., Sneitz, N., Mosorin, J., Hagström, M. & Finel, M., jan 2015, I : Drug Metabolism and Disposition. 43, 1, s. 107-118 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Exploring the structure-activity relationships of ABCC2 modulators using a screening approach

Wissel, G., Kudryavtsev, P., Ghemtio, L., Tammela, P., Wipf, P., Yliperttula, M., Finel, M., Urtti, A., Kidron, H. & Xhaard, H., 2015, I : Bioorganic & Medicinal Chemistry. 23, 13, s. 3513-3525 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Glucuronidation of estrone and 16 alpha-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7

Kallionpää, R. A., Järvinen, E. & Finel, M., nov 2015, I : Journal of Steroid Biochemistry and Molecular Biology. 154, s. 104-111 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences

Troberg, J. & Finel, M., 2015, I : Drug Metabolism and Disposition. 43, 11, s. 1769-1772 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

A Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its Derivatives

Greer, A. K., Dates, C. R., Starlard-Davenport, A., Edavana, V. K., Bratton, S. M., Dhakal, I. B., Finel, M., Kadlubar, S. A. & Radominska-Pandya, A., sep 2014, I : Drug Metabolism and Disposition. 42, 9, s. 1392-1400 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

SVM Classification and CoMSIA Modeling of UGT1A6 Interacting Molecules

Ghemtio, L., Soikkeli, A., Yliperttula, M., Hirvonen, J., Finel, M. & Xhaard, H., apr 2014, I : Journal of Chemical Information and Modeling. 54, 4, s. 1011-1026 16 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2013

A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes.

Rahikainen, T., Häkkinen, M. R., Finel, M., Pasanen, M. & Juvonen, R. O., 2013, I : Xenobiotica. 43, 10, s. 853-861 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects are Enzyme and Substrate Dependent

Manevski, N., Troberg, J., Svaluto-Moreolo, P., Dziedzic, K., Yli-Kauhaluoma, J. & Finel, M., 2013, I : PLoS One. 8, 1, s. e54767 15 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates

Suominen, T., Uutela, P., Ketola, R. A., Bergquist, J., Hillered, L., Finel, M., Zhang, H., Laakso, A. & Kostiainen, R., 27 jun 2013, I : PLoS One. 8, 6, 9 s., e68007.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.

Kato, Y., Izukawa, T., Oda, S., Fukami, T., Finel, M., Yokoi, T. & Nakajima, M., 2013, I : Drug Metabolism and Disposition. 41, 7, s. 1389-1397 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

Sneitz, N., Vahermo, M., Mosorin, J., Laakkonen, L., Poirier, D. & Finel, M., 2013, I : Drug Metabolism and Disposition. 41, 3, s. 582-591 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation

Perreault, M., Gauthier-Landry, L., Trottier, J., Verreault, M., Caron, P., Finel, M. & Barbier, O., 2013, I : Drug Metabolism and Disposition. 41, 9, s. 1616-1620 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2012

Analysis of R- and S-Hydroxywarfarin Glucuronidation Catalyzed by Human Liver Microsomes and Recombinant UDP-Glucuronosyltransferases

Bratton, S. M., Mosher, C. M., Khallouki, F., Finel, M., Court, M. H., Moran, J. H. & Radominska-Pandya, A., 2012, I : Journal of Pharmacology and Experimental Therapeutics. 340, 1, s. 46-55 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

Zhu, L., Ge, G., Zhang, H., Liu, H., He, G., Liang, S., Zhang, Y., Fang, Z., Dong, P., Finel, M. & Yang, L., 2012, I : Drug Metabolism and Disposition. 40, 3, s. 529-538 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia

Montenegro-Miranda, P. S., Sneitz, N., de Waart, D. R., ten Bloemendaal, L., Duijst, S., de Knegt, R. J., Beuers, U., Finel, M. & Bosma, P. J., 2012, I : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 8, s. 1223-1229 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases

Zhang, H., Soikkeli, A., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2012, I : Toxicology in Vitro. 26, 8, s. 1286-1293 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Impact of probe compound in MRP2 vesicular transport assays

Kidron, H., Wissel, G., Manevski, N., Hakli, M., Ketola, R. A., Finel, M., Yliperttula, M., Xhaard, H. & Urtti, A., 12 maj 2012, I : European Journal of Pharmaceutical Sciences. 46, 1-2, s. 100-105 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

Court, M. H., Zhang, X., Ding, X., Yee, K. K., Hesse, L. M. & Finel, M., 2012, I : Xenobiotica. 42, 3, s. 266-277 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10

Fedejko-Kap, B., Bratton, S. M., Finel, M., Radominska-Pandya, A. & Mazerska, Z., sep 2012, I : Drug Metabolism and Disposition. 40, 9, s. 1736-1743 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Bovine Serum Albumin Decreases K-m Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7 and Increases V-max Values of UGT1A9

Manevski, N., Moreolo, P. S., Yli-Kauhaluoma, J. & Finel, M., 2011, I : Drug Metabolism and Disposition. 39, 11, s. 2117-2129 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Effects of Cell Differentiation and Assay Conditions on the UDP-glucuronosyltransferases Activity in Caco-2 Cells.

Zhang, H., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2011, I : Drug Metabolism and Disposition. 39, 3, s. 456-464 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Fluorescence-Based High-Throughput Screening Assay for Drug Interactions with UGT1A6

Soikkeli, A., Kurkela, M., Hirvonen, J., Yliperttula, M. & Finel, M., 2011, I : Assay and drug development technologies. 9, 5, s. 496-502 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review