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Personlig profil

Meritförteckning

Languages:                                       Russian (native), English (fluent)

 

Specialization:                                  Molecular biology, biomedicine

 

Projects:                                                                     

2019-present                                       Identification of peripheral blood biomarkers and drug repurposing in hematological malignancies, University of Helsinki, Finland

 

  • Non-RTK inhibitors in AML therapy (joint project with Kronos Bio pharmaceutical company)
  • Immunophenotyping of BM-MNC population in patients with multiple myeloma, using CytOF method
  • Patient-tailored design of AML cell subpopulation-selective drug combinations
  • Optimization of cultivation condition for primary culture of blood cancer cell
  • Identification of biomarkers for personalized therapy of multiple myeloma
  • Evaluation of lncRNAs role in survivability of multiple myeloma patients

 

2019                                                   Contribution of adenosine N6-methylation in RNA to rRNA processing, Skolkovo   institute   of   Science   and Technology, Russia

2018                                                   Assessment of role of GILZ protein in a mouse model of liver fibrosis, Skolkovo   institute   of   Science   and Technology, Russia and University of Perugia, Italy

2016                                                   Ultrastructural study of gap junction proteins localization in modular rat brain groups, Southern Federal university, Russia

2015                                                   Studies on electrophysiological neurons’ activity with intracellular microelectrodes injection in A. fulica, Southern Federal university, Russia

 

Internships:

 

2018                                                   Internship    in    AstraZeneca    Company, business    development department

 

2018                                                   Internship in Carlo Riccardi’s lab, University of Perugia, Italy

 

 

Additional trainings:

 

2016                                                   Online course “Small business” on web-portal “Predprinimatelskii vseobuch” (Total education of entrepreneur), Centr-Invest bank

 

 

 

Honours, Awards, Achievements:

 

2017                                                    Diploma  for  the  3rd  place  in  the  event  of  ABB  SFU  "The  45th

Scientific Week of the 72nd Scientific Student Conference"

 

2016                                                   Gratitude for participation in the scientific and practical seminar

"Actual Problems of Fundamental and Applied Philosophy"

 

2016                                                   Diploma for the 3rd place in the event of ABB SFU "The 44th

Scientific Week of the 71st Scientific Student Conference"

 

2016                                                   Gratitude for participation in the meeting of SSS ABB SFU

 

2015                                                   Diploma for victory in the game ABB SFU “Chto? Gde? Kogda?”

 

2015                                                   Diploma for participation in the festival "Student Spring SFU"

 

2015                                                   Certificate of participation in the seminar "Perspectives of scientific and technological development of Russia until 2030"

 

2015                                                   Certificate for active participation in the events of the youth festival

"All-Russian Student Marathon"

 

Experience:                                        Microscopy, Electrophysiological researches of neurons’ activity with intracellular microelectrodes injection, tissue staining (i.  e. immunohistochemistry)  and  embedding,  basic  molecular  biology techniques,    FISH,    cell    cultures    working    and    transfection, immunoprecipitation  assays,  immunocytochemistry,  FACS, flow cytometry, fluorescence microscopy, primary cell culture work, data analysis with R language, work with acoustic liquid handlers, mass cytometry

 

 

 

Thesis and Publications:            

5. Juho J. Miettinen, Romika Kumari, Gunnhildur Asta Traustadottir, Maiju-Emilia Huppunen, Philipp Sergeev, Muntasir M. Majumder, Alexander Schepsky, Thorarinn Gudjonsson, Juha Lievonen, Despina Bazou, Paul Dowling, Peter O`Gorman, Ana Slipicevic, Pekka Anttila, Raija Silvennoinen, Nina N. Nupponen, Fredrik Lehmann, Caroline A. Heckman. Aminopeptidase Expression in Multiple Myeloma Associates with Disease (Manuscript)

4. Sara Flamini, Philipp Sergeev, Zenobio Antonio Viana de Barros, Tommaso Mello, Michele Biagioli, Chiara Fiorucci, Tatiana Prikazchikova, Stefano Pagano, Andrea Gagliardi, Carlo Riccardi, Timofei Zatsepin, Graziella Migliorati, Oxana Bereshchenko and Stefano Bruscoli. GILZ controls liver fibrosis via suppression of CCL2-mediated leukocyte recruitment (Manuscript)

3. Aleksandr Ianevski, Jenni Lahtela, Komal K. Javarappa, Philipp Sergeev, Bishwa R. Ghimire, Prson Gautam, Markus Vähä-Koskela, Laura Turunen, Nora Linnavirta, Heikki Kuusanmäki, Mika Kontro, Kimmo Porkka, Caroline A. Heckman, Pirkko Mattila, Krister Wennerberg, Anil K. Giri, Tero Aittokallio. Patient-tailored design of AML cell subpopulation-selective drug combinations (Manuscript)

2.Sergeeva O, Sergeev P, Melnikov P, Prikazchikova T, Dontsova O, Zatsepin T. Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation. Cells. 2020; 9(4):1061. Times cited: 0 (3.8.2020, Web of Science); IF 4.366; Rank 70/195 in Cell Biology)

1. Theses  in  the  materials  of  the  XXIII  Congress  of  the  Pavlov Physiological Society, September, 18-22, 2017, Voronezh "Immune electron  microscopy  study  of  connexin  proteins  in  rats’  thalamus nuclei" Kirichenko E. Yu., Filippova S. Yu., Sergeev Ph. S.

 

Forskningsintressen

Biology of hematologic malignancies, RNA biology, drug sensitivity, drug re-purposing, personalized medicine.

Utbildning information

2019–present                                      Enrollment in PhD degree program, Finnish Institute of Molecular Medicine, University of Helsinki, Finland

 

2017-2019                                          MSc degree with first class honours in Biology (Skolkovo institute of Science and Technology, Russia), Diploma original title: “Downregulation of adenosine N6-methylation in RNA  contributes to rRNA processing”,  scientific advisor – T. S. Zatsepin

 

2013-2017                                          Bachelor degree with honours in biology (Southern Federal University, Russia), Diploma original title: “Ультраструктурное исследование локализации белков щелевых контактов в модульных группировках мозга крыс”, Diploma translated title: Ultrastructural study of gap junctions proteins localization in modular rat brain groups” scientific advisor – E. Yu. Kirichenko

 

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Internationellt och inhemskt samarbete

Publikationer och projekt inom de senaste fem åren.