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Sakari Knuutila

1985 …2019
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Publikationer 1985 2019

2019

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Mäki-Nevala, S., Valo, S., Ristimaki, A., Sarhadi, V., Knuutila, S., Nyström, M., Renkonen-Sinisalo, L., Lepistö, A., Mecklin, J-P. & Peltomäki, P., jan 2019, I : EBioMedicine. 39, s. 280-291 12 s.

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Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer

Bao, J., Walliander, M., Kovacs, F., Nagaraj, A. S., Hemmes, A., Sarhadi, V. K., Knuutila, S., Lundin, J., Horvath, P. & Verschuren, E. W., 26 nov 2019, I : Scientific Reports. 9, 11 s., 17613.

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2018

Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin

Narvi, E., Vaparanta, K., Karrila, A., Chakroborty, D., Knuutila, S., Pulliainen, A., Sundvall, M. & Elenius, K., 8 nov 2018, I : Scientific Reports. 8, 13 s., 16579.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer

Youssef, O., Knuuttila, A., Piirilä, P., Böhling, T., Sarhadi, V. & Knuutila, S., okt 2018, I : Anticancer Research. 38, 10, s. 5627-5634 8 s.

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Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms

Youssef, O., Lahti, L., Kokkola, A., Karla, T., Tikkanen, M., Ehsan, H., Carpelan-Holmström, M. A., Koskensalo, S., Böhling, T., Rautelin, H., Puolakkainen, P., Knuutila, S. & Sarhadi, V., nov 2018, I : Digestive Diseases and Sciences. 63, 11, s. 2950-2958 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2017

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma

Veija, T., Koljonen, V., Bohling, T., Kero, M., Knuutila, S. & Sarhadi, V. K., 31 mar 2017, I : BMC Cancer. 17, 9 s., 236.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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ALK gene copy number in lung cancer: Unspecific polyploidy versus specific amplification visible as double minutes

Calio, A., Bria, E., Pilotto, S., Gilioli, E., Nottegar, A., Eccher, A., Cima, L., Santo, A., Pedron, S., Turri, G., Knuutila, S., Chilosi, M., Vanzo, F., Bogina, G., Terzi, A., Tortora, G., Scarpa, A., Loda, M., Martignoni, G. & Brunelli, M., 2017, I : Disease markers. Section A, Cancer biomarkers. 18, 2, s. 215-220 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia

Benard-Slagter, A., Zondervan, I., de Groot, K., Ghazavi, F., Sarhadi, V., Van Vlierberghe, P., De Moerloose, B., Schwab, C., Vettenranta, K., Harrison, C. J., Knuutila, S., Schouten, J., Lammens, T. & Savola, S., sep 2017, I : Journal of Molecular Diagnostics. 19, 5, s. 659-672 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Expression Analysis of Previously Verified Fecal and Plasma Down-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients

Ghanbari, R., Rezasoltani, S., Hashemi, J., Mohamadkhani, A., Tahmasebifar, A., Arefian, E., Mobarra, N., Asadi, J., Mojarad, E. N., Yazdani, Y., Knuutila, S. & Malekzadeh, R., feb 2017, I : Archives of Iranian Medicine. 20, 2, s. 92-95 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing

Youssef, O., Sarhadi, V., Ehsan, H., Böhling, T., Carpelan-Holmström, M., Koskensalo, S., Puolakkainen, P., Kokkola, A. & Knuutila, S., 21 dec 2017, I : World Journal of Gastroenterology. 23, 47, s. 8291-8299 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Low Expression of miR-18a as a Characteristic of Pediatric Acute Lymphoblastic Leukemia

Mosakhani, N., El Missiry, M., Vakkila, E., Knuutila, S. & Vakkila, J., nov 2017, I : Journal of pediatric hematology/oncology. 39, 8, s. 585-588 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination

Mosakhani, N., Sarhadi, V., Panula, P., Partinen, M. & Knuutila, S., nov 2017, I : Acta Neurologica Scandinavica. 136, 5, s. 462-469 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing

Youssef, O., Knuuttila, A., Piirilä, P., Böhling, T., Sarhadi, V. & Knuutila, S., 2017, I : Oncotarget. 8, 11, s. 18166-18176 11 s.

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Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome Tumor Heterogeneity in Clear-cell Renal Cell Carcinoma

Massari, F., Ciccarese, C., Bria, E., Porta, C., La Russa, F., Knuutila, S., Artibani, W., Porcaro, A. B., Bimbatti, D., Modena, A., Sava, T., Tortora, G., Cheng, L., Eccher, A., Cima, L., Pedron, S., Ghimenton, C., Martignoni, G. & Brunelli, M., jan 2017, I : Applied Immunohistochemistry & Molecular Morphology. 25, 1, s. 39-43 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Validation of 34betaE12 immunoexpression in clear cell papillary renal cell carcinoma as a sensitive biomarker

Martignoni, G., Brunelli, M., Segala, D., Munari, E., Gobbo, S., Cima, L., Borze, I., Wirtanen, T., Sarhadi, V. K., Atanesyan, L., Savola, S., Barzon, L., Masi, G., Fassan, M., Eble, J. N., Bohling, T., Cheng, L., Delahunt, B. & Knuutila, S., jan 2017, I : Pathology. 49, 1, s. 10-18 9 s.

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Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach

Fiorentino, M., Gruppioni, E., Massari, F., Giunchi, F., Altimari, A., Ciccarese, C., Bimbatti, D., Scarpa, A., Iacovelli, R., Porta, C., Virinder, S., Tortora, G., Artibani, W., Schiavina, R., Ardizzoni, A., Brunelli, M., Knuutila, S. & Martignoni, G., 2017, I : Oncotarget. 8, 5, s. 7328-7335 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing

Maki-Nevala, S., Sarhadi, V. K., Knuuttila, A., Scheinin, I., Ellonen, P., Lagstrom, S., Ronty, M., Kettunen, E., Husgafvel-Pursiainen, K., Wolff, H. & Knuutila, S., feb 2016, I : Lung. 194, 1, s. 125-135 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing

Armengol, G., Sarhadi, V. K., Ghanbari, R., Doghaei-Moghaddam, M., Ansari, R., Sotoudeh, M., Puolakkainen, P., Kokkola, A., Malekzadeh, R. & Knuutila, S., jul 2016, I : Journal of Molecular Diagnostics. 18, 4, s. 471-479 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers-A Mini-Review

Youssef, O., Sarhadi, V., Knuuttila, A. H., Piirilä, P., Armengol, G. & Knuutila, S., dec 2016, I : Genes, Chromosomes & Cancer. 55, 12, s. 905-914 10 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Hot spot mutations in Finnish non-small cell lung cancers

Maki-Nevala, S., Sarhadi, V. K., Ronty, M., Kettunen, E., Husgafvel-Pursiainen, K., Wolff, H., Knuuttila, A. & Knuutila, S., sep 2016, I : Lung Cancer. 99, s. 102-110 9 s.

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Hotspot mutations in polyomavirus positive and negative Merkel cell carcinomas

Veija, T., Sarhadi, V. K., Koljonen, V., Bohling, T. & Knuutila, S., 2016, I : Cancer Genetics. 209, 1-2, s. 30-35 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Mutations by Next Generation Sequencing in Stool DNA from Colorectal Carcinoma Patients. A Literature Review and our Experience with this Methodology

Youssef, O., Sarhadi, V. K., Lehtimäki, L., Tikkanen, M., Kokkola, A., Puolakkainen, P., Armengol, G. & Knuutila, S., jan 2016, I : Journal of Analytical Oncology. 5, 1, s. 24-32 9 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking beta-Catenin/TCF Regulated Transcription

Abdel-Rahman, W. M., Lotsari-Salomaa, J. E., Kaur, S., Niskakoski (o.s. Tieva), A., Knuutila, S., Järvinen, H., Mecklin, J-P. & Peltomaki, P., 2016, I : Gastroenterology Research and Practice. 11 s., 6089658.

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2015

Cytogenetic and molecular genetic alterations in bone tumors

Niini, T. J. & Knuutila, S., 2015, Bone Cancer: Primary Bone Cancers and Bone Metastases. Heymann, D. (red.). 2nd edition red. Elsevier Academic Press, s. 319-339 21 s.

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer

Ghanbari, R., Mosakhani, N., Asadi, J., Nouraee, N., Mowla, S. J., Poustchi, H., Malekzadeh, R. & Knuutila, S., 2015, I : Disease markers. Section A, Cancer biomarkers. 15, 2, s. 195-201 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Downregulation of plasma MiR-142-3p and MiR-26a-5p in patients with colorectal carcinoma

Ghanbari, R., Mosakhani, N., Asadi, J., Nouraee, N., Mowla, S. J., Yazdani, Y., Mohamadkhani, A., Poustchi, H., Knuutila, S. & Malekzadeh, R., 2015, I : Iranian Journal of Cancer Prevention. 8, 3, 6 s., e2329.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Driver Gene Mutations of Non-Small-Cell Lung Cancer are Rare in Primary Carcinoids of the Lung: NGS Study by Ion Torrent

Armengol, G., Sarhadi, V. K., Ronty, M., Tikkanen, M., Knuuttila, A. & Knuutila, S., apr 2015, I : Lung. 193, 2, s. 303-308 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement

Sarhadia, V. K., Parkkinen, J., Reito, A., Nieminen, J., Porkka, N., Wirtanen, T., Laitinen, M., Eskelinen, A. & Knuutila, S., nov 2015, I : Mutation research : International journal of mutagenesis, chromosome breakage and related subjects.. 781, s. 1-6 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma

Veija, T., Sahi, H., Koljonen, V., Bohling, T., Knuutila, S. & Mosakhani, N., mar 2015, I : Virchows Archiv. 466, 3, s. 289-295 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of SUCLA2 point mutation and 13q14 deletion

Matilainen, S., Isohanni, P., Euro, L., Lonnqvist, T., Pihko, H., Kivela, T., Knuutila, S. & Suomalainen, A., mar 2015, I : European Journal of Human Genetics. 23, 3, s. 325-330 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Monosomy of chromosome 17 in breast cancer during interpretation of HER2 gene amplification

Brunelli, M., Nottegar, A., Bogina, G., Calio, A., Cima, L., Eccher, A., Vicentini, C., Marcolini, L., Scarpa, A., Pedron, S., Brunello, E., Knuutila, S., Sapino, A., Marchio, C., Bria, E., Molino, A., Carbognin, L., Tortora, G., Jasani, B., Miller, K. & 10 andra, Merdol, I., Zanatta, L., Laurino, L., Wirtanen, T., Zamboni, G., Marconi, M., Chilosi, M., Manfrin, E., Martignoni, G. & Bonetti, F., 2015, I : American journal of cancer research. 5, 7, s. 2212-2221 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Pehmytkudoskasvainten diagnostiikka - moniammatillista yhteistyötä

Söderström, M., Dalin-Hirvonen, N., Mattila, K., Knuutila, S. & Kallajoki, M., 2015, I : Duodecim. 131, 8, s. 769-780 12 s.

Forskningsoutput: TidskriftsbidragArtikelProfessionell

Simultaneous Underexpression of let-7a-5p and let-7f-5p microRNAs in Plasma and Stool Samples from Early Stage Colorectal Carcinoma: Supplementary Issue: Biomarkers for Colon Cancer

Ghanbari, R., Mosakhani, N., Sarhadi, V. K., Armengol, G., Nouraee, N., Mohammadkhani, A., Khorrami, S., Arefian, E., Paryan, M., Malekzadeh, R. & Knuutila, S., 1 jan 2015, I : Biomarkers in Cancer. 7, Suppl 1, s. 39–48 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2014

ALK/EML4 Fusion Gene May Be Found in Pure Squamous Carcinoma of the Lung

Calio, A., Nottegar, A., Gilioli, E., Bria, E., Pilotto, S., Peretti, U., Kinspergher, S., Simionato, F., Pedron, S., Knuutila, S., Tortora, G., Eccher, A., Santo, A., Tondulli, L., Inghirami, G., Tabbo, F., Martignoni, G., Chilosi, M., Scarpa, A. & Brunelli, M., maj 2014, I : Journal of thoracic oncology.. 9, 5, s. 729-732 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

ALK Fusion and Its Association with Other Driver Gene Mutations in Finnish Non-Small Cell Lung Cancer Patients

Tuononen, K., Kero, M., Maki-Nevala, S., Sarhadi, V. K., Tikkanen, M., Wirtanen, T., Ronty, M. J., Knuuttila, A. & Knuutila, S., 1 nov 2014, I : Genes, Chromosomes & Cancer. 53, 11, s. 895-901 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Burkitt Lymphoma and Ewing Sarcoma in a Child With Williams Syndrome

Vanhapiha, N., Knuutila, S., Vettenranta, K. & Lohi, O., 1 okt 2014, I : Pediatric Blood & Cancer. 61, 10, s. 1877-1879 3 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Copy Number Alterations and Neoplasia-Specific Mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in Different Neoplasias

Sarhadi, V. K., Lahti, L., Scheinin, I., Ellonen, P., Kettunen, E., Serra, M., Scotlandi, K., Picci, P. & Knuutila, S., jul 2014, I : Genes, Chromosomes & Cancer. 53, 7, s. 579-588 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Differentiating soft tissue leiomyosarcoma and undifferentiated pleomorphic sarcoma: A miRNA analysis

Guled, M., Pazzaglia, L., Borze, I., Mosakhani, N., Novello, C., Benassi, M. S. & Knuutila, S., 1 aug 2014, I : Genes, Chromosomes & Cancer. 53, 8, s. 693-702 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Epidermal Growth Factor Receptor Mutations in 510 Finnish Non-Small-Cell Lung Cancer Patients

Maki-Nevala, S., Ronty, M., Morel, M., Gomez, M., Dawson, Z., Sarhadi, V. K., Telaranta-Keerie, A., Knuuttila, A. & Knuutila, S., jun 2014, I : Journal of thoracic oncology.. 9, 6, s. 886-891 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

High-resolution SNP array analysis of patients with developmental disorder and normal array CGH result (vol 13, 84, 2012)

Siggberg, L., Ala-Mello, S., Linnankivi, T., Avela, K., Scheinin, I., Kristiansson, K., Lahermo, P., Hietala, M., Metsähonkala, L., Kuusinen, E., Laaksonen, M., Saarela, J. & Knuutila, S., 18 nov 2014, I : BMC Medical Genetics. 15, 1 s., 124.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Hoidollisesti merkittävien mutaatioiden testaaminen suolistosyövässä kohdistetulla uuden polven sekvensoinnilla

Knuutila, S., Mosakhani, N., Sarhadi, V., Mäki-Nevala, S., Wirtanen, T., Karjalainen-Lindsberg, M-L., Ellonen, P. & Österlund, P., 2014, I : Solubiologi. 32, 1, s. 21-29 9 s.

Forskningsoutput: TidskriftsbidragArtikelProfessionell

Hsa-miR-31-3p Expression Is Linked to Progression-free Survival in Patients with KRAS Wild-type Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy

Manceau, G., Imbeaud, S., Thiebaut, R., Liebaert, F., Fontaine, K., Rousseau, F., Genin, B., Le Corre, D., Didelot, A., Vincent, M., Bachet, J-B., Chibaudel, B., Bouche, O., Landi, B., Bibeau, F., Leroy, K., Penault-Llorca, F., Van Laethem, J-L., Demetter, P., Tejpar, S. & 9 andra, Rossi, S., Mosakhani, N., Osterlund, P., Ristamaki, R., Sarhadi, V., Knuutila, S., Boige, V., Andre, T. & Laurent-Puig, P., 15 jun 2014, I : Clinical Cancer Research. 20, 12, s. 3338-3347 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Malignant Mesothelioma: Mechanism of Carcinogenesis

Kane, A. B., Jean, D., Knuutila, S. & Jaurand, M-C., 2014, Occupational Cancers. Anttila, S. & Boffetta, P. (red.). London: Springer, s. 299-319 21 s.

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Malignant mesothelioma (molecular markers)

Kettunen, E. & Knuutila, S., 2014, Occupational Cancers: Clinical and Pathological Features, Assessment and Diagnosis. Anttila, S., Boffetta, P. & Straif, K. (red.). London: Springer

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

MicroRNA Expression Profiles in Kaposi's Sarcoma

Catrina (Ene), A. M., Borze, I., Guled, M., Costache, M., Leen, G., Sajin, M., Ionica, E., Chitu, A. & Knuutila, S., jan 2014, I : Pathology & oncology research. 20, 1, s. 153-159 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Renal cell carcinoma with smooth muscle stroma lacks chromosome 3p and VHL alterations

Martignoni, G., Brunelli, M., Segala, D., Gobbo, S., Borze, I., Atanesyan, L., Savola, S., Barzon, L., Masi, G., Tardanico, R., Zhang, S., Eble, J. N., Chilosi, M., Bohling, T., Cheng, L., Delahunt, B. & Knuutila, S., maj 2014, I : Modern Pathology. 27, 5, s. 765-774 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2013

Comparison of Targeted Next-Generation Sequencing (NGS) and Real-Time PCR in the Detection of EGFR, KRAS, and BRAF Mutations on Formalin-Fixed, Paraffin-Embedded Tumor Material of Non-Small Cell Lung Carcinoma-Superiority of NGS

Tuononen, K., Mäki-Nevala, S., Sarhadi, V. K., Wirtanen, A., Rönty, M. J., Salmenkivi, K., Andrews, J. M., Telaranta-Keerie, A. I., Hannula, S., Lagström, S., Ellonen, P., Knuuttila, A. & Knuutila, S., 1 maj 2013, I : Genes, Chromosomes & Cancer. 52, 5, s. 503-511 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia

Mosakhani, N., Mustjoki, S. & Knuutila, S., 16 jul 2013, I : Molecular cytogenetics. 6, 3 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskaplig