Foto av Sanna Lehtonen

Sanna Lehtonen

Professor

  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

1993 …2020

Research output per year

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Personlig profil

Information om forskning och undervisning

Diabetic nephropathy, the serious renal complication of diabetes, starts with albuminuria and can lead to end stage renal disease. Insulin resistance is associated with an increased risk for the development of diabetic nephropathy. Interestingly, the glomerular epithelial cells or podocytes have recently been shown to be insulin responsive and to increase their glucose uptake upon insulin stimulation. It has also been shown that filamentous actin cytoskeleton is required for the insulin response and further, nephrin, a key structural component of podocytes, is essential for insulin action in these cells. Our group aims to characterize the pathophysiological mechanims involved in the early stages of diabetic nephropathy and the development of albuminuria. Specifically, we are interested in analyzing the role of insulin signaling and glucose transport and the regulation of actin cytoskeleton in podocytes.

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes

Berg, M. E. A., Naams, J-B., Hautala, L., Tolvanen, T., Ahonen, J., Lehtonen, S. & Wähälä, K., 28 jan 2020, I : ACS Omega. 5, 3, s. 1430-1438 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors

Lehtonen, S., jan 2020, I : Acta Physiologica. 228, 1, 22 s., 13349.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Öppen tillgång
Fil

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Wang, H., Kuusela, S., Rinnankoski-Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A-M., Chi, N-W., Krauss, S., Pirinen, E. & Lehtonen, S., 21 apr 2020, I : International Journal of Obesity. 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Editorial: Podocyte Pathology and Nephropathy-An Update

Lehtonen, S. & Lewko, B., 30 jul 2019, I : Frontiers in Endocrinology. 10, 3 s., 528.

Forskningsoutput: TidskriftsbidragLedareVetenskapligPeer review

Öppen tillgång
Fil

Projekter

Aktiviteter

Abstract reviewer for the American Diabetes Association's 80th Meeting 2020 (Evenemang)

Sanna Lehtonen (Expert)
2020 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i granskningskommitté

HUS:n erva tutkimustoimikunta (Extern organisation)

Sanna Lehtonen (Medlem)
2020 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Tidningsurklipp

Short communication in Duodecim, section In press

Sanna Lehtonen

21/12/2018

1 Mediabidrag

Press/media: !!Press / Media

Interview in Helsingin Sanomat

Sanna Lehtonen

25/10/2018

1 Mediabidrag

Press/media: !!Press / Media

Interview in Apteekkari, section Lääkeuutiset

Sanna Lehtonen

15/12/2017

1 Mediabidrag

Press/media: !!Press / Media

Interview for Europa-newsletter Ajassa

Sanna Lehtonen

01/01/2016

1 Mediabidrag

Press/media: !!Press / Media

Interview at MTV-lava, Pori

Sanna Lehtonen

15/07/2015

1 Mediabidrag

Press/media: !!Press / Media