1993 …2019
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Personlig profil

Information om forskning och undervisning

Diabetic nephropathy, the serious renal complication of diabetes, starts with albuminuria and can lead to end stage renal disease. Insulin resistance is associated with an increased risk for the development of diabetic nephropathy. Interestingly, the glomerular epithelial cells or podocytes have recently been shown to be insulin responsive and to increase their glucose uptake upon insulin stimulation. It has also been shown that filamentous actin cytoskeleton is required for the insulin response and further, nephrin, a key structural component of podocytes, is essential for insulin action in these cells. Our group aims to characterize the pathophysiological mechanims involved in the early stages of diabetic nephropathy and the development of albuminuria. Specifically, we are interested in analyzing the role of insulin signaling and glucose transport and the regulation of actin cytoskeleton in podocytes.

Keywords

  • 3111 Biomedicinska vetenskaper

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1993 2019

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., feb 2019, I : FASEB Journal. 33, 2, s. 2858-2869 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?

Wasik, A. A. & Lehtonen, S., 9 apr 2018, I : Frontiers in Endocrinology. 9, 12 s., 155.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

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Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 sep 2017, I : Scientific Reports. 7, 14 s., 10731.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Metformin and the catalytic activity of SHIP2

Berg, M. E. A., Tolvanen, T. A., Polianskyte-Prause, Z., Lindfors, S. H., Wähälä, K. & Lehtonen, S. H., 27 aug 2017, s. 125. 1 s.

Forskningsoutput: KonferensbidragPosterForskning

PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

Dumont, V., Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisén, H., Suetsugu, S., Plomann, M., Kawachi, H. & Lehtonen, S., sep 2017, I : FASEB Journal. 31, 18 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Projekter 2017 2019

SHIBNESS: Business from SHIP2 inhibitors TEKES

Lehtonen, S. & Wähälä, K.

01/09/201731/08/2019

Projekt: Forskningsprojekt

Aktiviteter 1991 2019

Amr Elseragy's thesis supervisory board member

Sanna Lehtonen (Handledare)
2019 → …

Aktivitet: ExaminationstyperMedlem i doktorsavhandlingskommitté

The Paulo Foundation (Extern organisation)

Sanna Lehtonen (Styrelsemedlem)
2019 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Evaluator, final examination/Amudhala Karthik, TRANSMED MSc programme (Evenemang)

Sanna Lehtonen (Styrelsemedlem)
11 jun 2018

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i granskningskommitté

Press / media

Short communication in Duodecim, section In press

Sanna Lehtonen

21/12/2018

1 mediabidrag

Press/media: !!Press / Media

Interview in Helsingin Sanomat

Sanna Lehtonen

25/10/2018

1 mediabidrag

Press/media: !!Press / Media

Interview in Apteekkari, section Lääkeuutiset

Sanna Lehtonen

15/12/2017

1 mediabidrag

Press/media: !!Press / Media

Interview for Europa-newsletter Ajassa

Sanna Lehtonen

01/01/2016

1 mediabidrag

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Interview at MTV-lava, Pori

Sanna Lehtonen

15/07/2015

1 mediabidrag

Press/media: !!Press / Media