Foto på T. Sakari Jokiranta

T. Sakari Jokiranta

1988 …2019
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Personlig profil

Meritförteckning

EDUCATION

Licentiate of Medicine (MD equiv.), University of Helsinki, 31 May 1995

Doctor of Medical Sciences (PhD equiv.), University of Helsinki,14 Dec 1999

Certified specialist in Clinical Microbiology, Univ. of Helsinki, 3 Aug 2001

Docent (Adjunct Professor)  in Medical Microbiology and Immunology, Univ. of Helsinki, 5 Jan 2006

Meritförteckning

CURRENT POSITIONS

Clinical teacher (Senior lecturer), permanent position Univ. of Helsinki, Finland   1 Aug 2008-

R&D Manager (part-time), United Medix Laboratories Ltd., Espoo                      1 Oct 2009-

Information om forskning och undervisning

Jokiranta research group is a scientific work group lead by T. Sakari Jokiranta at Haartman-institute, University of Helsinki, Finland. The focus of the research is in function of an important arm of innate immunity, the alternative pathway of complement. The main question is how that system leaves the host structures intact while destroying the invading pathogenic microbes.There are two projects to answer to the main question. (1) Protection of the glomerular structures by complement factor H and pathogenesis of the kidney diseases that develop when thend. The focus and main question in this project is how the alternative pathway of complement works as a part of the innate immunity to leave protection is insufficient (membranoproliferative glomerulonephritis type II/ dense deposit disease and atypical haemolytic uremic syndrome). (2) Mechanisms of complement evasion of certain microbes (e.g. Streptococcus pyogenes, Borrelia recurrentis, B. duttonii, Bordetella pertussis) by actively binding host factor H to their surface. The research is currently financed by the Academy of Finland, the Sigrid Juselius Foundation, and Helsinki University Central Hospital Funds.

Vetenskapsgrenar

  • 311 Basmedicin
  • 312 Klinisk medicin

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1988 2019

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

Kajander, T., Lehtinen, M. J., Hyvärinen, S., Bhattacharjee, A., Leung, E., Isenman, D. E., Meri, S., Goldman, A. & Jokiranta, T. S., 2011, I : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, s. 2897-2902 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome

Lehtinen, M. J., Rops, A. L., Isenman, D. E., van der Vlag, J. & Jokiranta, T. S., 2009, I : Journal of Biological Chemistry. 284, 23, s. 15650-15658 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes

Haapasalo, K., Jarva, H., Siljander, T., Tewodros, W., Vuopio-Varkila, J. & Jokiranta, T. S., 2008, I : Molecular Microbiology. 70, 3, s. 583-594 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor H

Jalanko, H., Peltonen, S., Koskinen, A., Puntila, J., Isoniemi, H., Holmberg, C., Pinomäki, A., Armstrong, E., Koivusalo, A., Tukiainen, E., Mäkisalo, H., Saland, J., Remuzzi, G., de Cordoba, S. R., Lassila, R., Meri, S. & Jokiranta, S., 2008, I : American Journal of Transplantation. 8, 1, s. 216-221 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome

Jokiranta, T. S., Jaakola, V-P., Lehtinen, M. J., Pärepalo, M-J., Meri, S. & Goldman, A., 2006, I : EMBO Journal. 25, 8, s. 1784-1794 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Aktiviteter 2003 2014

ECN board (Extern organisation)

T. Sakari Jokiranta (Styrelsemedlem)
25 aug 2009 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

European autoimmunity standardization initiative (Extern organisation)

T. Sakari Jokiranta (Styrelsemedlem)
14 sep 2009 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Laatutoimikunta (Extern organisation)

T. Sakari Jokiranta (Styrelsemedlem)
2010 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

YVV-toimikunta (Extern organisation)

T. Sakari Jokiranta (Styrelsemedlem)
2010 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

International Complement Standardization Committee (Extern organisation)

T. Sakari Jokiranta (Styrelsemedlem)
15 okt 2008 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse