Forskningsresultat per år
Forskningsresultat per år
Sökresultat
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2024
Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase
Jones, A. G., Aquilino, M., Tinker, R. J., Duncan, L., Jenkins, Z., Carvill, G. L., DeWard, S. J., Grange, D. K., Hajianpour, M. J., Halliday, B. J., Holder-Espinasse, M., Horvath, J., Maitz, S., Nigro, V., Morleo, M., Paul, V., Spencer, C., Esterhuizen, A. I., Polster, T. & Spano, A. & 8 andra, , 4 apr. 2024, I: American Journal of Human Genetics. 111, 4, s. 729-741 13 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Dynamic changes in mitochondrial localization in human neocortical basal radial glial cells during cell cycle
Gkini, V., Gómez-Lozano, I., Heikinheimo, O. & Namba, T., juni 2024, I: Journal of Comparative Neurology. 532, 6, 11 s., e25630.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development
Xing, L., Gkini, V., Nieminen, A. I., Zhou, H.-C., Aquilino, M., Naumann, R., Reppe, K., Tanaka, K., Carmeliet, P., Heikinheimo, O., Pääbo, S., Huttner, W. B. & Namba, T., apr. 2024, I: Nature Communications. 15, 13 s., 3468.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Xing, L., Huttner, W. B. & Namba, T., sep. 2024, I: Neurobiology of Disease. 199, 8 s., 106607.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2023
Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex
Vaid, S., Heikinheimo, O. & Namba, T., mars 2023, I: Journal of Neural Transmission. 130, 3, s. 185–194 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2022
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids
Fischer, J., Ortuno, E. F., Marsoner, F., Artioli, A., Peters, J., Namba, T., Oegema, C. E., Huttner, W. B., Ladewig, J. & Heide, M., 7 nov. 2022, I: EMBO Reports. 23, 11, 19 s., 54728.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
Pinson, A., Xing, L., Namba, T., Kalebic, N., Peters, J., Oegema, C. E., Traikov, S., Reppe, K., Riesenberg, S., Maricic, T., derihaci, R., Wimberger, P., Paabo, S. & Huttner, W. B., 9 sep. 2022, I: Science. 377, 6611, s. 1170-+ 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2021
Ex vivo Tissue Culture Protocols for Studying the Developing Neocortex
Namba, T., Haffner, C. & Huttner, W. B., 20 maj 2021, I: Bio-Protocol. 11, 10, 11 s., 4031.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution
Kalebic, N. & Namba, T., sep. 2021, I: Development. 148, 17, 13 s., 199417.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis
Bedrosian, T. A., Houtman, J., Eguiguren, J. S., Ghassemzadeh, S., Rund, N., Novaresi, N. M., Hu, L., Parylak, S. L., Denli, A. M., Randolph-Moore, L., Namba, T., Gage, F. H. & Toda, T., 1 feb. 2021, I: EMBO Journal. 40, 3, 21 s., 105819.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Metabolic Regulation of Neocortical Expansion in Development and Evolution
Namba, T., Nardelli, J., Gressens, P. & Huttner, W. B., 3 feb. 2021, I: Neuron. 109, 3, s. 408-419 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2020
Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis
Namba, T., Doczi, J., Pinson, A., Xing, L., Kalebic, N., Wilsch-Braeuninger, M., Long, K. R., Vaid, S., Lauer, J., Bogdanova, A., Borgonovo, B., Shevchenko, A., Keller, P., Drechsel, D., Kurzchalia, T., Wimberger, P., Chinopoulos, C. & Huttner, W. B., 4 mars 2020, I: Neuron. 105, 5, s. 867-+ 24 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Signs of Reduced Basal Progenitor Levels and Cortical Neurogenesis in Human Fetuses with Open Spina Bifida at 11-15 Weeks of Gestation
Fietz, S. A., Namba, T., Kirsten, H., Huttner, W. B. & Lachmann, R., 19 feb. 2020, I: Journal of Neuroscience. 40, 8, s. 1766-1777 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2019
Analysis of proliferating neuronal progenitors and immature neurons in the human hippocampus surgically removed from control and epileptic patients
Seki, T., Hori, T., Miyata, H., Maehara, M. & Namba, T., 3 dec. 2019, I: Scientific Reports. 9, 14 s., 18194.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology
Kalebic, N., Gilardi, C., Stepien, B., Wilsch-Braeuninger, M., Long, K. R., Namba, T., Florio, M., Langen, B., Lombardot, B., Shevchenko, A., Kilimann, M. W., Kawasaki, H., Wimberger, P. & Huttner, W. B., 4 apr. 2019, I: Cell Stem Cell. 24, 4, s. 535-+ 25 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Non-radial tortuous migration with cell polarity alterations of newly generated granule neurons in the neonatal rat dentate gyrus
Namba, T., Shinohara, H. & Seki, T., dec. 2019, I: Brain structure & function. 224, 9, s. 3247-3262 16 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Primate neocortex development and evolution: Conserved versus evolved folding
Namba, T., Vaid, S. & Huttner, W. B., 1 juli 2019, I: Journal of Comparative Neurology. 527, 10, s. 1621-1632 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex
Kostic, M., Paridaen, J. T. M. L., Long, K. R., Kalebic, N., Langen, B., Gruebling, N., Wimberger, P., Kawasaki, H., Namba, T. & Huttner, W. B., 23 apr. 2019, I: Cell Reports. 27, 4, s. 1103-+ 22 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2018
A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex
Vaid, S., Camp, J. G., Hersemann, L., Oegema, C. E., Heninger, A.-K., Winkler, S., Brandl, H., Sarov, M., Treutlein, B., Huttner, W. B. & Namba, T., okt. 2018, I: Development. 145, 20, 15 s., 169276.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
Kalebic, N., Gilardi, C., Albert, M., Namba, T., Long, K. R., Kostic, M., Langen, B. & Huttner, W. B., 28 nov. 2018, I: eLife. 7, 25 s., 41241.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7
Tavano, S., Taverna, E., Kalebic, N., Haffner, C., Namba, T., Dahl, A., Wilsch-Braeuninger, M., Paridaen, J. T. M. L. & Huttner, W. B., 21 mars 2018, I: Neuron. 97, 6, s. 1299-+ 24 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2017
Discovery of long-range inhibitory signaling to ensure single axon formation
Takano, T., Wu, M., Nakamuta, S., Naoki, H., Ishizawa, N., Namba, T., Watanabe, T., Xu, C., Hamaguchi, T., Yura, Y., Amano, M., Hahn, K. M. & Kaibuchi, K., 26 juni 2017, I: Nature Communications. 8, 18 s., 33.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex
Namba, T. & Huttner, W. B., 2017, I: Wiley interdisciplinary reviews-Developmental biology. 6, 1, 16 s., 256.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats
Izumida, H., Takagi, H., Fujisawa, H., Iwata, N., Nakashima, K., Takeuchi, S., Iwama, S., Namba, T., Komatu, Y., Kaibuchi, K., Oiso, Y., Arima, H. & Sugimura, Y., jan. 2017, I: Experimental Neurology. 287, s. 65-74 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2016
A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification
Florio, M., Namba, T., Paeaebo, S., Hiller, M. & Huttner, W. B., dec. 2016, I: Science Advances. 2, 12, 7 s., 1601941.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2015
Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity
Tsuboi, D., Kuroda, K., Tanaka, M., Namba, T., Iizuka, Y., Taya, S., Shinoda, T., Hikita, T., Muraoka, S., Iizuka, M., Nimura, A., Mizoguchi, A., Shiina, N., Sokabe, M., Okano, H., Mikoshiba, K. & Kaibuchi, K., maj 2015, I: Nature Neuroscience. 18, 5, s. 698-+ 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
Florio, M., Albert, M., Taverna, E., Namba, T., Brandl, H., Lewitus, E., Haffner, C., Sykes, A., Wong, F. K., Peters, J., Guhr, E., Klemroth, S., Pruefer, K., Kelso, J., Naumann, R., Nuesslein, I., Dahl, A., Lachmann, R., Paeaebo, S. & Huttner, W. B., 27 mars 2015, I: Science. 347, 6229, s. 1465-1470 6 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Neuronal polarization
Takano, T., Xu, C., Funahashi, Y., Namba, T. & Kaibuchi, K., 15 juni 2015, I: Development. 142, 12, s. 2088-2093 6 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site
Xu, C., Funahashi, Y., Watanabe, T., Takano, T., Nakamuta, S., Namba, T. & Kaibuchi, K., 28 okt. 2015, I: Journal of Neuroscience. 35, 43, s. 14517-14532 16 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2014
Minimum Information about a Spinal Cord Injury Experiment: A Proposed Reporting Standard for Spinal Cord Injury Experiments
MIASCI Consortium & Namba, T., 1 aug. 2014, I: Journal of Neurotrauma. 31, 15, s. 1354-1361 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex
Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., Oda, K., Wada, Y., Masuda, T., Sakakibara, A., Igarashi, M., Miyata, T., Faivre-Sarrailh, C., Takeuchi, K. & Kaibuchi, K., 19 feb. 2014, I: Neuron. 81, 4, s. 814-829 16 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine: Implications for enhanced hippocampal adult neurogenesis
Ishikawa, R., Kim, R., Namba, T., Kohsaka, S., Uchino, S. & Kida, S., juli 2014, I: Hippocampus. 24, 7, s. 784-793 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2013
ERK2-Mediated Phosphorylation of Par3 Regulates Neuronal Polarization
Funahashi, Y., Namba, T., Fujisue, S., Itoh, N., Nakamuta, S., Kato, K., Shimada, A., Xu, C., Shan, W., Nishioka, T. & Kaibuchi, K., 14 aug. 2013, I: Journal of Neuroscience. 33, 33, s. 13270-13285 16 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Metamorphosis of mesothelial cells with active horizontal motility in tissue culture
Nagai, H., Chew, S. H., Okazaki, Y., Funahashi, S., Namba, T., Kato, T., Enomoto, A., Jiang, L., Akatsuka, S. & Toyokuni, S., 28 jan. 2013, I: Scientific Reports. 3, 7 s., 1144.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Robo1 Regulates the Migration and Laminar Distribution of Upper-Layer Pyramidal Neurons of the Cerebral Cortex
Gonda, Y., Andrews, W. D., Tabata, H., Namba, T., Parnavelas, J. G., Nakajima, K., Kohsaka, S., Hanashima, C. & Uchino, S., juni 2013, I: Cerebral Cortex. 23, 6, s. 1495-1508 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding
Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y., Ota, K., Oda, K., Wada, Y., Sagou, K., Saito, K., Sakakibara, A., Kawaguchi, A., Nakajima, K., Adachi, T., Fujimori, T., Ueda, M. & Hayashi, S. & 2 andra, , nov. 2013, I: Nature Neuroscience. 16, 11, s. 1556-1566 11 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2011
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse
Kuroda, K., Yamada, S., Tanaka, M., Iizuka, M., Yano, H., Mori, D., Tsuboi, D., Nishioka, T., Namba, T., Iizuka, Y., Kubota, S., Nagai, T., Ibi, D., Wang, R., Enomoto, A., Isotani-Sakakibara, M., Asai, N., Kimura, K., Kiyonari, H. & Abe, T. & 5 andra, , 1 dec. 2011, I: Human Molecular Genetics. 20, 23, s. 4666-4683 18 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain
Wang, Y., Kaneko, N., Asai, N., Enomoto, A., Isotani-Sakakibara, M., Kato, T., Asai, M., Murakumo, Y., Ota, H., Hikita, T., Namba, T., Kuroda, K., Kaibuchi, K., Ming, G.-L., Song, H., Sawamoto, K. & Takahashi, M., 1 juni 2011, I: Journal of Neuroscience. 31, 22, s. 8109-8122 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin-Dependent Protein Kinases
Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, M. R., Tokumitsu, H., Soderling, T. R., Sakakibara, A., Miyata, T., Kamiguchi, H. & Kaibuchi, K., 15 nov. 2011, I: Science signaling. 4, 199, 13 s., 76.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1)
Namba, T., Ming, G.-L., Song, H., Waga, C., Enomoto, A., Kaibuchi, K., Kohsaka, S. & Uchino, S., juli 2011, I: Journal of Neurochemistry. 118, 1, s. 34-44 11 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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The Role of Selective Transport in Neuronal Polarization
Namba, T., Nakamuta, S., Funahashi, Y. & Kaibuchi, K., juni 2011, I: Developmental Neurobiology. 71, 6, s. 445-457 13 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Time-Lapse Imaging Reveals Symmetric Neurogenic Cell Division of GFAP-Expressing Progenitors for Expansion of Postnatal Dentate Granule Neurons
Namba, T., Mochizuki, H., Suzuki, R., Onodera, M., Yamaguchi, M., Namiki, H., Shioda, S. & Seki, T., 23 sep. 2011, I: PLoS One. 6, 9, 11 s., 25303.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2010
Effects of Repeated Electroconvulsive Seizure on Cell Proliferation in the Rat Hippocampus
Ito, M., Seki, T., Liu, J., Nakamura, K., Namba, T., Matsubara, Y., Suzuki, T. & Arai, H., nov. 2010, I: Synapse (New York). 64, 11, s. 814-821 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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GLIAL FIBRILLARY ACIDIC PROTEIN-EXPRESSING NEURAL PROGENITORS GIVE RISE TO IMMATURE NEURONS VIA EARLY INTERMEDIATE PROGENITORS EXPRESSING BOTH GLIAL FIBRILLARY ACIDIC PROTEIN AND NEURONAL MARKERS IN THE ADULT HIPPOCAMPUS
Liu, Y., Namba, T., Liu, J., Suzuki, R., Shioda, S. & Seki, T., 10 mars 2010, I: Neuroscience. 166, 1, s. 241-251 11 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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PIGMENT EPITHELIUM-DERIVED FACTOR UP-REGULATION INDUCED BY MEMANTINE, AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, IS INVOLVED IN INCREASED PROLIFERATION OF HIPPOCAMPAL PROGENITOR CELLS
Namba, T., Yabe, T., Gonda, Y., Ichikawa, N., Sanagi, T., Arikawa-Hirasawa, E., Mochizuki, H., Kohsaka, S. & Uchino, S., 5 maj 2010, I: Neuroscience. 167, 2, s. 372-383 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2009
NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus
Maekawa, M., Namba, T., Suzuki, E., Yuasa, S., Kohsaka, S. & Uchino, S., apr. 2009, I: Neuroscience Research. 63, 4, s. 259-266 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Prenatal Phencyclidine Exposure Alters Hippocampal Cell Proliferation in Offspring Rats
Tanimura, A., Liu, J., Namba, T., Seki, T., Matsubara, Y., Itoh, M., Suzuki, T. & Arai, H., sep. 2009, I: Synapse (New York). 63, 9, s. 729-736 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus
Enomoto, A., Asai, N., Namba, T., Wang, Y., Kato, T., Tanaka, M., Tatsumi, H., Taya, S., Tsuboi, D., Kuroda, K., Kaneko, N., Sawamoto, K., Miyamoto, R., Jijiwa, M., Murakumo, Y., Sokabe, M., Seki, T., Kaibuchi, K. & Takahashi, M., 24 sep. 2009, I: Neuron. 63, 6, s. 774-787 14 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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The Alzheimer's Disease Drug Memantine Increases the Number of Radial Glia-like Progenitor Cells in Adult Hippocampus
Namba, T., Maekawa, M., Yuasa, S., Kohsaka, S. & Uchino, S., 1 aug. 2009, I: Glia. 57, 10, s. 1082-1090 9 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2007
Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus
Seki, T., Namba, T., Mochizuki, H. & Onodera, M., 10 maj 2007, I: Journal of Comparative Neurology. 502, 2, s. 275-290 16 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review