Tiina Paunio

  • PL 22 (Välskärinkatu 12)

    00014

    Finland

  • PL 22 (Välskärinkatu 12)

    HELSINGIN YLIOPISTO

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1992 …2024

Forskningsoutput per år

Personlig profil

Meritförteckning

https://www.helsinki.fi/en/researchgroups/sleep-and-health

Meritförteckning

I performed my PhD work at the laboratory of Professor Leena Peltonen-Palotie  during 1990-1995. This work led to DNA diagnostics of gelsolin-related amyloidosis and revelation of pathogenic processing of mutant gelsolin in neuronal cells. During a 2-year post doc period (1996-1998) at LGN-CNRS, Paris, I developed novel recombinant adenoviral vectors for gene therapy on an experimental model of Parkinson’s disease. Then, my focus shifted towards research on psychiatric traits and I started working as a project leader for large international collaboration on schizophrenia. This work led to understanding the truly heterogeneous background of psychosis as well as connections between genes, cognitive disturbances, and schizophrenia.

From year 2003, my main research focus has been on understanding the molecular mechanisms for disturbed mood and sleep and their relationship. We have revealed association of two genes, DISC1 and DAOA, to intermediate traits for BPD and we were able to replicate some of the findings from earlier genome-wide association studies. We found in a large nation-wide cohort of twins that poor sleep predicted depressed mood in a consistent pattern, while depressed mood did not predict poor sleep, evidencing for the central role of disturbed sleep in mood disorders. We have also found inter-individual variability in sleep quality-related responses to stressful life events and relation of childhood traumatic events to insomnia in adulthood. We found in a systematic association study in a population-based sample that some susceptibility genes associate to depression only in the presence of disturbed sleep. We also found a link between a bipolar susceptibility gene and visual performance, evidencing further for the direct neurobiological link between visual perception, circadian rhythm, and regulation of mood.

Vetenskapsgrenar

  • 3112 Neurovetenskaper

Internationellt och inhemskt samarbete

Publikationer och projekt inom de senaste fem åren.
  • The 8th Finnish Symposium of Biological Psychiatry

    Annette Horstmann (Ordförande i organisationskommitté), Tiina Paunio (Ordförande i organisationskommitté), Iiris Hovatta (Medlem i organisationskommitté), Katri Kantojarvi (Medlem i organisationskommitté), Hendrik Hartmann (Medlem i organisationskommitté) & Katri Leena Wegelius (Sekreterare i organisationskommitté)

    19 dec. 2022

    Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

  • AMEE 2019

    Taina Hintsa (Talare: Presentation), Anne Helena Monni (Närvarande), Eeva Pyörälä (Närvarande), Marko Elovainio (Närvarande), Saara Repo (Närvarande) & Tiina Paunio (Närvarande)

    24 aug. 201928 aug. 2019

    Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

  • AMEE 2019

    Saara Repo (Talare: Presentation), Tiina Paunio (Närvarande), Eeva Pyörälä (Närvarande), Marianne Holopainen (Närvarande), panajiota Räsänen (Närvarande) & Marko Elovainio (Närvarande)

    24 aug. 201928 aug. 2019

    Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

  • AMEE 2017

    Tiina Maria Paunio (Poster presentation), Eeva Pyörälä (Poster presentation), Jussi Jukka Saarinen (Poster presentation), Kari Risto Johannes Peltola (Närvarande), Jonne Juntura (Poster presentation) & Marko Juhani Elovainio (Poster presentation)

    26 aug. 201730 aug. 2017

    Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

  • Hosting a Seminar at Evidence-Based Psychotherapy

    Tiina Paunio (Ordförande)

    11 jan. 2016

    Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium