Foto på Tomi Mäkelä
  • Finland

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1986 …2019
Om du gjort några ändringar i Pure kommer de visas här snart.

Personlig profil

Meritförteckning

Director, Helsinki Institute of Life Science HiLIFE

Vice Director, Academy of Finland Center of Excellence in Translational Genome-Scale Biology

Information om forskning och undervisning

Kinase signaling linking metabolism and growth control

Major human diseases such as diabetes and cancer are due to deregulat- ed signaling stemming from genetic alterations and extrinsic factors. Signaling in pathways and in larger networks typically involves sequential activation of kinases phosphorylating substrates and thus relaying and amplifying signals ultimately mod- ulating transcriptional responses in target gene sets. Our longstanding interest is to characterize signaling pathways regulating mammalian cell growth and how these impinge on transcriptional responses in human disease.

tabolism are the transcriptional kinases Cdk7 and Cdk8 mediating signals to RNA polymerase II. We are investigating the molecular mechanisms and in vivo functions of Cdk7 and Cdlk8 combining mouse molecular genetics with Drosophila knockdown strategies and cell-based screening approaches. Recent discoveries include identify- ing that Cdk7 acts as a roadblock to adipogenesis and that this presumed ubiquitous basal transcription factor is not expressed in fat tissues. Our goal is to understand the basis for the specificity of transcriptional regulation by metazoan Cdk7 and Cdk8 and their contribution to growth control and differentiation.

One of the rare kinases acting normally to restrict tumor growth is the LKB1ser- ine/threonine kinase critical for activation of at least 14 related kinases involved in metabolism and polarity regulation. We are interested in how LKB1 mediates its tumor suppressing function, and recently identified that LKB1 signaling in mesen- chymal cells is required for suppression of epithelial hyperproliferation in a mouse polyposis model and likely also in the human Peutz-Jeghers syndrome. We are cur- rently extending investigations of tumor suppression mechanisms of the LKB1 tu- mor suppressor kinase from hereditary polyposis to sporadic cancer (lung, uterine cervix). For this a combination of tissue- and cell type specific targeting approaches in vivo (conditional mouse models) and in vitro (2D and 3D RNAi & conditional dele- tions) of LKB1 and LKB1 substrate mutations will be used with a specific interest in the Nuak2 and AMPK kinases and cytoskeletal regulation.

 

 

Vetenskapsgrenar

  • 118 Biovetenskaper
  • 311 Basmedicin

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1986 2019

  • 83 Artikel
  • 4 Översiktsartikel
  • 2 Konferensartikel

The LKB1 tumor suppressor kinase in human disease

Katajisto, P., Vallenius, T., Vaahtomeri, K., Ekman, N., Udd, L., Tiainen, M. & Makela, T. P., 2007, I : Biochimica et Biophysica Acta. Reviews on Cancer. 1775, 1, s. 63-75 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells

Kuuluvainen, E., Domenech-Moreno, E., Niemela, E. H. & Makela, T. P., jun 2018, I : Molecular and Cellular Biology. 38, 12, 15 s., UNSP e00573-17.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Increased alpha-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer

Kovac, B., Makela, T. P. & Vallenius, T., 9 maj 2018, I : PLoS One. 13, 5, 20 s., 0196986.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Ollila, S., Domenech-Moreno, E., Laajanen, K., Wong, I. P. L., Tripathi, S., Pentinmikko, N., Gao, Y., Yan, Y., Niemelä, E. H., Wang, T. C., Viollet, B., Leone, G., Katajisto, P., Vaahtomeri, K. & Mäkelä, T. P., 2 jan 2018, I : Journal of Clinical Investigation. 128, 1, s. 402-414 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

Priser

Anders Jahre Young Investigator Award

Tomi Mäkelä (!!Recipient), 1 jan 2005

Pris: Pris och hedersbetygelser

Membeship of the Finnish Academy of Science and Letters

Tomi Mäkelä (!!Recipient), 2002

Pris: Pris och hedersbetygelser

Aktiviteter 1996 2010

ENFIN (Extern organisation)

Tomi Mäkelä (Ordförande)
5 okt 20106 okt 2010

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Univ Helsinki (Extern organisation)

Tomi Mäkelä (Styrelsemedlem)
2010

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Univ Helsinki, Faculty of Medicine (Extern organisation)

Tomi Mäkelä (Ordförande)
3 jun 2010

Aktivitet: MedlemskapstyperMedlemskap eller annan role i inhemsk/internationell kommitté, råd, styrelse

Biocenter Finland (Extern organisation)

Tomi Mäkelä (Styrelsemedlem)
1 jan 2010 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i inhemskt/internationellt offentligt organ

Press / media

Radiaattori: telomeraasista Nobel / Sisko Loikkanen

Tomi Mäkelä

21/10/2010

1 Mediabidrag

Press/media: !!Press / Media

Tomi Mäkelä Helsingin biotekniikan instituutin johtoon

Tomi Mäkelä

16/01/2009

1 Mediabidrag

Press/media: !!Press / Media

Kiinnostus tutkijan työhön uhkaa hiipua

Tomi Mäkelä

01/01/2009

1 Mediabidrag

Press/media: !!Press / Media

Science Days Finland 2007: Opportunities from Cancer Biology

Tomi Mäkelä

10/01/2007

1 Mediabidrag

Press/media: !!Press / Media