Foto av Veli-Matti Leppänen

Veli-Matti Leppänen

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

20042020

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Publikationer

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2020

Investigation on the role of biallelic variants in VEGF-C found in a patient affected by Milroy-like lymphedema

Mukenge, S., Jha, S. K., Catena, M., Manara, E., Leppänen, V-M., Lenti, E., Negrini, D., Bertelli, M., Brendolan, A., Jeltsch, M. & Aldrighetti, L., 26 jun 2020, I : Molecular Genetics & Genomic Medicine. 10 s., 1389.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche

Fang, S., Chen, S., Leppänen, V-M., Nurmi, H., Jeltsch, M., Scadden, D. T., Silberstein, L., Mikkola, H. & Alitalo, K., 25 aug 2020, I : Blood.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2019

Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib

Crona, D. J., Skol, A. D., Leppänen, V-M., Glubb, D. M., Etheridge, A. S., Hilliard, E., Pena, C. E., Peterson, Y. K., Klauber-DeMore, N., Alitalo, K. K. & Innocenti, F., 1 jan 2019, I : Cancer Research. 79, 1, s. 231-241 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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High baseline Tie1 level predicts poor survival in metastatic breast cancer

Tiainen, L., Korhonen, E. A., Leppänen, V-M., Luukkaala, T., Hämäläinen, M., Tanner, M., Lahdenperä, O., Vihinen, P., Jukkola, A., Karihtala, P., Aho, S., Moilanen, E., Alitalo, K. & Kellokumpu-Lehtinen, P-L., 24 jul 2019, I : BMC Cancer. 19, 10 s., 732.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2018

Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells

Högström, J., Heino, S., Kallio, P., Lähde, M., Leppänen, V-M., Balboa, D., Wiener, Z. & Alitalo, K., 15 okt 2018, I : Cancer Research. 78, 20, s. 5820-5832 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Vascular endothelial growth factor signaling in development and disease

Karaman, S., Leppänen, V-M. & Alitalo, K., 15 jul 2018, I : Development. 145, 14, 8 s., 151019.

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2017

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Jha, S. K., Rauniyar, K., Kärpänen, T., Leppänen, V-M., Brouillard, P., Vikkula, M., Alitalo, K. & Jeltsch, M., 7 jul 2017, I : Scientific Reports. 7, 13 s., 4916.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

Leppanen, V-M., Saharinen, P. & Alitalo, K., 25 apr 2017, I : Proceedings of the National Academy of Sciences of the United States of America. 114, 17, s. 4376-4381 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2016

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., apr 2016, I : American Journal of Transplantation. 16, 4, s. 1160-1172 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 apr 2016, I : Cell Metabolism. 23, 4, s. 712-724 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2015

Endothelial destabilization by angiopoietin-2 via integrin beta 1 activation

Hakanpaa, L., Sipila, T., Leppanen, V-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K. & Saharinen, P., jan 2015, I : Nature Communications. 6, 12 s., 5962.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Functional Dissection of the CCBE1 Protein A Crucial Requirement for the Collagen Repeat Domain

Roukens, M. G., Peterson-Maduro, J., Padberg, Y., Jeltsch, M., Leppanen, V-M., Bos, F. L., Alitalo, K., Schulte-Merker, S. & Schulte, D., 8 maj 2015, I : Circulation Research. 116, 10, s. 1660-U153 22 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 maj 2014, I : Circulation . 129, 19, s. 1962-1971 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Aspelund, A., Tammela, T., Antila, S., Nurmi, H. J., Leppanen, V-M., Zarkada, G., Stanczuk, L., Francois, M., Makinen, T., Saharinen, P., Immonen, I. & Alitalo, K., sep 2014, I : Journal of Clinical Investigation. 124, 9, s. 3975-3986 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2013

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization

Gaal, E. I., Tammela, T., Anisimov, A., Marbacher, S., Honkanen, P., Zarkada, G., Leppänen, V-M., Tatlisumak, T., Hernesniemi, J., Niemelä, M. & Alitalo, K., 1 aug 2013, I : Blood. 122, 5, s. 658-665 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Receptor Tyrosine Kinase-Mediated Angiogenesis

Jeltsch, M., Leppänen, V-M., Saharinen, P. & Alitalo, K., sep 2013, I : Cold Spring Harbor Perspectives in Biology. 5, 9, s. Article Number: a009183 22 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Leppänen, V-M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K. N., Ballmer-Hofer, K. & Alitalo, K., 6 aug 2013, I : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, s. 12960-12965 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V-M., An, Y., Han, E. C., Orsenigo, F., Gaal, E. I., Holopainen, T., Koh, Y. J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G. Y., Choi, C., Saharinen, P. & Alitalo, K., 2013, I : Circulation . 127, 4, s. 424-434 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2012

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

Brozzo, M. S., Bjelic, S., Kisko, K., Schleier, T., Leppanen, V-M., Alitalo, K., Winkler, F. K. & Ballmer-Hofer, K., 2012, I : Blood. 119, 7, s. 1781-1788 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering

Kisko, K., Brozzo, M. S., Missimer, J., Schleier, T., Menzel, A., Leppänen, V-M., Alitalo, K., Walzthoeni, T., Aebersold, R. & Ballmer-Hofer, K., 2011, I : FASEB Journal. 25, 9, s. 2980-2986 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

Leppänen, V-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Ylä-Herttuala, S., Ballmer-Hofer, K. & Alitalo, K., 2011, I : Blood. 117, 5, s. 1507-1515 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2010

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, I : Cancer Cell. 18, 6, s. 630-640 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Structural determinants of growth factor binding and specificity by VEGF receptor 2

Leppänen, V-M., Prota, A. E., Jeltsch, M., Anisimov, A., Kalkkinen, N., Strandin, T., Lankinen, H., Goldman, A., Ballmer-Hofer, K. & Alitalo, K., 2010, I : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, s. 2425-2430 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2009

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

Anisimov, A., Alitalo, A., Korpisalo, P., Soronen, J., Kaijalainen, S., Leppanen, V-M., Jeltsch, M., Yla-Herttuala, S. & Alitalo, K., 2009, I : Circulation Research. 104, s. 1302-U156 25 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional

Parkash, V., Lindholm, P., Peränen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppänen, V-M. & Goldman, A., 2009, I : Protein Engineering, Design and Selection. 22, 4, s. 233-241 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2008

The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding

Parkash, V., Leppänen, V-M., Virtanen, H., Jurvansuu, J. M., Bespalov, M. M., Sidorova, Y. A., Runeberg-Roos, P., Saarma, M. & Goldman, A., 2008, I : Journal of Biological Chemistry. 283, 12, s. 35164-35172 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2007

Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family

Leppänen, V-M., Tossavainen, H., Permi, P., Lehtiö, L., Rönnholm, G., Goldman, A., Kilpeläinen, I. & Pihlajamaa, T., 2007, I : Journal of Biological Chemistry. 282, 32, s. 23219-23230 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, I : Nature. 448, 7147, s. 73-78 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The mouse soluble GFR4 receptor activates RET independently of its ligand persephin

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2007, I : Oncogene. 26, s. 3892-3898 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2006

The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin.

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2006, I : Oncogene. 26, s. 3892-3898

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2005

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75(NTR)

Aurikko, JP., Ruotolo, BT., Grossmann, JG., Moncrieffe, MC., Stephens, E., Leppänen, V-M., Robinson, CV., Saarma, M., Bradshaw, RA. & Blundell, TL., 30 sep 2005, I : Journal of Biological Chemistry. 280, 39, s. 33453-33460 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75[sup NTR]

Aurikko, J. P., Ruotolo, B. T., Grossmann, J. G., Moncrieffe, M. C., Stephens, E., Leppänen, V-M., Robinson, C. V., Saarma, M., Bradshaw, R. A. & Blundell, T. L., 2005, I : Journal of Biological Chemistry. 280, 39, s. 33453 - 33460 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The first cysteine-rich domain of the receptor GFR alpha 1 stabilizes the binding of GDNF

Virtanen, H., Yang, JM., Bespalov, MM., Hiltunen, JO., Leppanen, VM., Kalkkinen, N., Goldman, A., Saarma, M. & Runeberg-Roos, P., 2005, I : Biochemical Journal. 387, s. 817-824 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2004

The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

Leppänen, V-M., Bespalov, M., Runeberg-Roos, P., Puurand, Ü., Merits, A., Saarma, M. & Goldman, A., 2004, I : EMBO Journal. 23, s. 1452-1462

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review