• PL 68 (Pietari Kalmin katu 5)

    00014

    Finland

20062020

Forskningsoutput per år

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Publikationer

2020

An Unusual Amino Acid Substitution Within Hummingbird Cytochrome c Oxidase Alters a Key Proton-Conducting Channel

Dunn, C., Akpinar, A. & Sharma, V., 1 jul 2020, I : G3 - Genes genomes genetics. 10, 7, s. 2477-2485 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice

Purhonen, J., Grigorjev, V., Ekiert, R., Aho, N., Rajendran, J., Pietras, R., Truve, K., Wikström, M., Sharma, V., Osyczka, A., Fellman, V. & Kallijärvi, J., 16 jan 2020, I : Nature Communications. 11, 1, 12 s., 322.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Coupling of quinone dynamics to proton pumping in respiratory complex I

Haapanen, O., Reidelbach, M. & Sharma, V., 1 dec 2020, I : Biochimica et Biophysica Acta. Bioenergetics. 1861, 12, 6 s., 148287.

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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., Stanly, T. A., Prieto, K. D. P., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 feb 2020, I : Science. 367, 6478, s. 643-+ 58 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I

Uno, S., Masuya, T., Shinzawa-Itoh, K., Lasham, J., Haapanen, O., Shiba, T., Inaoka, D. K., Sharma, V., Murai, M. & Miyoshi, H., 21 feb 2020, I : Journal of Biological Chemistry. 295, 8, s. 2449-2463 15 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Proton motive function of the terminal antiporter-like subunit in respiratory complex I

Djurabekova, A., Haapanen, O. & Sharma, V., 1 jul 2020, I : Biochimica et Biophysica Acta. Bioenergetics. 1861, 7, 7 s., 148185.

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2019

After all, how many catalytically active quinone molecules are bound to the respiratory complex I?

Haapanen, O., Parey, K., Yoga, E. G., Zickermann, V. & Sharma, V., jun 2019.

Forskningsoutput: KonferensbidragPoster

After all, how many catalytically active quinone molecules are bound to the respiratory complex I?

Haapanen, O., Parey, K., Yoga, E. G., Zickermann, V. & Sharma, V., aug 2019.

Forskningsoutput: KonferensbidragSammanfattning

Atomistic insights into cardiolipin binding sites of cytochrome c oxidase

Malkamäki, A. E. M. & Sharma, V., 1 mar 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 3, s. 224-232 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Cytochrome c Oxidase: Remaining Questions About the Catalytic Mechanism

Wikström, M. & Sharma, V., 2019, Oxygen Production and Reduction in Artificial and Natural Systems. Barber, J., Ruban, A. V. & Nixon, P. J. (red.). Singapore: World Scientific, s. 135-145 11 s.

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskaplig

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High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

Parey, K., Haapanen, O., Sharma, V., Köfeler, H., Züllig, T., Prinz, S., Siegmund, K., Wittig, I., Mills, D. J., Vonck, J., Kühlbrandt, W. & Zickermann, V., dec 2019, I : Science Advances. 5, 12, 10 s., 9484.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Modelling insights into the function of respiratory complex cytochrome bc1

Lasham, J., Osyczka, A. & Sharma, V., 20 aug 2019.

Forskningsoutput: KonferensbidragPoster

Multiscale simulation approaches to understand biological energy conversion in the inner mitochondrial membrane

Sharma, V., Haapanen, O., Djurabekova, A., Yoga, E. G., Parey, K. & Zickermann, V., aug 2019.

Forskningsoutput: KonferensbidragSammanfattning

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics

Yoga, E. G., Haapanen, O., Wittig, I., Siegmund, K., Sharma, V. & Zickermann, V., 1 jul 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 7, s. 573-581 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus

Chiarini, V., Tossavainen, H., Sharma, V. & Colotti, G., apr 2019, I : Biochimica et Biophysica Acta. General Subjects. 1863, 4, s. 749-759 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Proton Transfer in Cytochrome c Oxidase

Reidelbach, M., Sharma, V. & Rich, P. R., 2019.

Forskningsoutput: KonferensbidragSammanfattning

Proton Transfer in Cytochrome c Oxidase

Reidelbach, M., Sharma, V. & Rich, P. R., 2019.

Forskningsoutput: KonferensbidragPoster

Proton transfer in cytochrome c oxidase studied by multiscale simulations

Reidelbach, M., Sharma, V. & Rich, P. R., 2019.

Forskningsoutput: KonferensbidragSammanfattning

Proton transfer in cytochrome c oxidase studied by multiscale simulations

Reidelbach, M., Sharma, V. & Rich, P. R., 2019.

Forskningsoutput: KonferensbidragPoster

Proton transfer pathways in the antiporter-like subunits of complex I revealed by multiscale simulations

Djurabekova, A., Haapanen, O. & Sharma, V., 1 jul 2019.

Forskningsoutput: KonferensbidragSammanfattning

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

Haapanen, O., Djurabekova, A. & Sharma, V., 9 apr 2019, I : Frontiers in Chemistry. 7, 14 s., 221.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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The H channel is not a proton transfer path in yeast cytochrome c oxidase

Malkamäki, A., Meunier, B., Reidelbach, M., Rich, P. R. & Sharma, V., 1 sep 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 9, s. 717-723 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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The high-resolution cryo-EM structure of respiratory complex I from the aerobic yeast Yarrowia lipolytica

Zickermann, V., Parey, K., Haapanen, O., Sharma, V., Mills, D. J., Vonck, J. & Kuhlbrandt, W., aug 2019.

Forskningsoutput: KonferensbidragSammanfattning

2018

A Common Core Coupling Mechanism for Mitochondrial and Bacterial A-type Cytochrome c Oxidases?

Rich, P. R., Sharma, V., Meunier, B. & Marechal, A., 2018, s. e21. 1 s.

Forskningsoutput: KonferensbidragSammanfattning

A highly conserved loop in the PSST subunit of complex I is essential for ubiquinone binding and reduction

Yoga, E. G., Haapanen, O., Sharma, V. & Zickermann, V., 2018.

Forskningsoutput: KonferensbidragSammanfattning

A modeling and simulation perspective on the mechanism and function of respiratory complex I

Haapanen, O. & Sharma, V., jul 2018, I : Biochimica et Biophysica Acta. Bioenergetics. 1859, 7, s. 510-523 14 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

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Cytochrome c oxidase – a molecular machine

Wikström, M. K. F. & Sharma, V., 2018.

Forskningsoutput: KonferensbidragSammanfattning

Oxygen Activation and Energy Conservation by Cytochrome c Oxidase

Wikström, M. K. F., Krab, K. & Sharma, V., 14 mar 2018, I : Chemical Reviews. 118, 5, s. 2469–2490 22 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

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Oxygen Reduction and Proton Translocation by Respiratory Cytochrome c Oxidase

Wikström, M. K. F. & Sharma, V., 2018, Dioxygen-dependent Heme Enzymes. Ikeda-Saito, M. & Raven, E. (red.). Cambridge: Royal Society of Chemistry, s. 311-333 23 s. (RSC Metallobiology Series; vol. 13).

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Proton pumping by cytochrome c oxidase: A 40 year anniversary

Wikström, M. & Sharma, V., sep 2018, I : Biochimica et Biophysica Acta. Bioenergetics. 1859, 9, s. 692-698 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Proton Transfer in Cytochrome c Oxidase

Reidelbach, M. U. & Sharma, V., 2018.

Forskningsoutput: KonferensbidragPoster

Quinone Dynamics Coupled to Proton Pumping in Bacterial and Mammalian Respiratory Complex I

Haapanen, O., Djurabekova, A. & Sharma, V., 2018. 1 s.

Forskningsoutput: KonferensbidragSammanfattning

Redox-coupled quinone dynamics in the respiratory complex I

Warnau, J., Sharma, V., Gamiz-Hernandez, A. P., Di Luca, A., Haapanen, O., Vattulainen, I., Wikström, M., Hummer, G. & Kaila, V. R. I., 4 sep 2018, I : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, s. E8413-E8420 8 s.

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2017

Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase gamma: Novel Mechanisms of Function and Pathogenesis

Euro, L., Haapanen, O., Rog, T., Vattulainen, I., Suomalainen, A. & Sharma, V., 7 mar 2017, I : Biochemistry. 56, 9, s. 1227-1238 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Insights into functions of the H channel of cytochrome c oxidase from atomistic molecular dynamics simulations

Sharma, V., Jambrina, P. G., Kaukonen, M., Rosta, E. & Rich, P. R., 28 nov 2017, I : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, s. E10339-E10348 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Redox-driven proton pumping in respiratory complex I: a molecular dynamics simulation study

Haapanen, O. & Sharma, V., jul 2017, I : European Biophysics Journal. 46, Supplement 1, s. S216-S216 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Role of water and protein dynamics in proton pumping by respiratory complex I

Haapanen, O. & Sharma, V., 10 aug 2017, I : Scientific Reports. 7, 12 s., 7747.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Structural Basis for Human Thrombopoietin Receptor Recognition by Janus Kinases

Vuorio, J., Sharma, V., Poojari, C. S., Piehler, J. & Vattulainen, I. T., 2017, s. 180. 1 s.

Forskningsoutput: KonferensbidragPoster

2016

Distribution and dynamics of quinones in the lipid bilayer mimicking the inner membrane of mitochondria

Kaurola, P., Sharma, V., Vonk, A., Vattulainen, I. & Rog, T., sep 2016, I : Biochimica et Biophysica Acta. Biomembranes. 1858, 9, s. 2116-2122 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase

Sharma, V. & Wikstrom, M., aug 2016, I : Biochimica et Biophysica Acta. Bioenergetics. 1857, 8, s. 1111-1115 5 s.

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2015

New Perspectives on Proton Pumping in Cellular Respiration

Wikström, M., Sharma, V., Kaila, V. R. I., Hosler, J. P. & Hummer, G., 11 mar 2015, I : Chemical Reviews. 115, 5, s. 2196-2221 26 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase

Sharma, V., Enkavi, G., Vattulainen, I., Rog, T. & Wikström, M., 17 feb 2015, I : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, s. 2040-2045 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Redox-induced activation of the proton pump in the respiratory complex I

Sharma, V., Belevich, G., Gamiz-Hernandez, A. P., Rog, T., Vattulainen, I., Verkhovskaya, M. L., Wikström, M., Hummer, G. & Kaila, V. R. I., 15 sep 2015, I : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, s. 11571-11576 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review