• PL 68 (Pietari Kalmin katu 5)

    00014

    Finland

20062020

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Publikationer

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2020

An Unusual Amino Acid Substitution Within Hummingbird Cytochrome c Oxidase Alters a Key Proton-Conducting Channel

Dunn, C., Akpinar, A. & Sharma, V., 1 jul 2020, I : G3 - Genes genomes genetics. 10, 7, s. 2477-2485 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice

Purhonen, J., Grigorjev, V., Ekiert, R., Aho, N., Rajendran, J., Pietras, R., Truve, K., Wikström, M., Sharma, V., Osyczka, A., Fellman, V. & Kallijärvi, J., 16 jan 2020, I : Nature Communications. 11, 1, 12 s., 322.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Coupling of quinone dynamics to proton pumping in respiratory complex I

Haapanen, O., Reidelbach, M. & Sharma, V., 1 dec 2020, I : Biochimica et Biophysica Acta. Bioenergetics. 1861, 12, 6 s., 148287.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., Stanly, T. A., Prieto, K. D. P., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 feb 2020, I : Science. 367, 6478, s. 643-+ 58 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I

Uno, S., Masuya, T., Shinzawa-Itoh, K., Lasham, J., Haapanen, O., Shiba, T., Inaoka, D. K., Sharma, V., Murai, M. & Miyoshi, H., 21 feb 2020, I : Journal of Biological Chemistry. 295, 8, s. 2449-2463 15 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Proton motive function of the terminal antiporter-like subunit in respiratory complex I

Djurabekova, A., Haapanen, O. & Sharma, V., 1 jul 2020, I : Biochimica et Biophysica Acta. Bioenergetics. 1861, 7, 7 s., 148185.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2019

Atomistic insights into cardiolipin binding sites of cytochrome c oxidase

Malkamäki, A. E. M. & Sharma, V., 1 mar 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 3, s. 224-232 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

Parey, K., Haapanen, O., Sharma, V., Köfeler, H., Züllig, T., Prinz, S., Siegmund, K., Wittig, I., Mills, D. J., Vonck, J., Kühlbrandt, W. & Zickermann, V., dec 2019, I : Science Advances. 5, 12, 10 s., 9484.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics

Yoga, E. G., Haapanen, O., Wittig, I., Siegmund, K., Sharma, V. & Zickermann, V., 1 jul 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 7, s. 573-581 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus

Chiarini, V., Tossavainen, H., Sharma, V. & Colotti, G., apr 2019, I : Biochimica et Biophysica Acta. General Subjects. 1863, 4, s. 749-759 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

Haapanen, O., Djurabekova, A. & Sharma, V., 9 apr 2019, I : Frontiers in Chemistry. 7, 14 s., 221.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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The H channel is not a proton transfer path in yeast cytochrome c oxidase

Malkamäki, A., Meunier, B., Reidelbach, M., Rich, P. R. & Sharma, V., 1 sep 2019, I : Biochimica et Biophysica Acta. Bioenergetics. 1860, 9, s. 717-723 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2018

Proton pumping by cytochrome c oxidase: A 40 year anniversary

Wikström, M. & Sharma, V., sep 2018, I : Biochimica et Biophysica Acta. Bioenergetics. 1859, 9, s. 692-698 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Redox-coupled quinone dynamics in the respiratory complex I

Warnau, J., Sharma, V., Gamiz-Hernandez, A. P., Di Luca, A., Haapanen, O., Vattulainen, I., Wikström, M., Hummer, G. & Kaila, V. R. I., 4 sep 2018, I : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, s. E8413-E8420 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2017

Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase gamma: Novel Mechanisms of Function and Pathogenesis

Euro, L., Haapanen, O., Rog, T., Vattulainen, I., Suomalainen, A. & Sharma, V., 7 mar 2017, I : Biochemistry. 56, 9, s. 1227-1238 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Insights into functions of the H channel of cytochrome c oxidase from atomistic molecular dynamics simulations

Sharma, V., Jambrina, P. G., Kaukonen, M., Rosta, E. & Rich, P. R., 28 nov 2017, I : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, s. E10339-E10348 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Role of water and protein dynamics in proton pumping by respiratory complex I

Haapanen, O. & Sharma, V., 10 aug 2017, I : Scientific Reports. 7, 12 s., 7747.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2016

Distribution and dynamics of quinones in the lipid bilayer mimicking the inner membrane of mitochondria

Kaurola, P., Sharma, V., Vonk, A., Vattulainen, I. & Rog, T., sep 2016, I : Biochimica et Biophysica Acta. Biomembranes. 1858, 9, s. 2116-2122 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase

Sharma, V. & Wikstrom, M., aug 2016, I : Biochimica et Biophysica Acta. Bioenergetics. 1857, 8, s. 1111-1115 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2015

Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase

Sharma, V., Enkavi, G., Vattulainen, I., Rog, T. & Wikström, M., 17 feb 2015, I : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, s. 2040-2045 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Redox-induced activation of the proton pump in the respiratory complex I

Sharma, V., Belevich, G., Gamiz-Hernandez, A. P., Rog, T., Vattulainen, I., Verkhovskaya, M. L., Wikström, M., Hummer, G. & Kaila, V. R. I., 15 sep 2015, I : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, s. 11571-11576 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Role of subunit III and its lipids in the molecular mechanism of cytochrome c oxidase

Sharma, V., Ala-Vannesluoma, P., Vattulainen, I. T., Wikström, M. K. F. & Rog, T., 17 apr 2015, I : Biochimica et Biophysica Acta. Bioenergetics. 1847, 8, s. 690-697 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

A structural and functional perspective on the evolution of the heme-copper oxidases

Sharma, V. & Wikstrom, M., 2014, I : FEBS Letters. 588, 21, s. 3787-3792 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2013

A single amino acid residue controls ROS production in the respiratory Complex I from Escherichia coli

Knuuti, J., Belevich, G., Sharma, V., Bloch, D. A. & Verkhovskaya, M., dec 2013, I : Molecular Microbiology. 90, 6, s. 1190-1200 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase

Sharma, V., Karlin, KD. & Wikström, M., 2013, I : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, s. 16844-16849 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2012

Dynamic water networks in cytochrome cbb(3) oxidase

Sharma, V., Wikström, M. & Kaila, V. R. I., maj 2012, I : Biochimica et Biophysica Acta. Bioenergetics. 1817, 5, s. 726-734 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Stabilization of the peroxy intermediate in the oxygen splitting reaction of cytochrome cbb(3)

Sharma, V., Wikström, M. & Kaila, V., 2011, I : Biochimica et Biophysica Acta. Bioenergetics. 1807, 7, s. 813-818 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

The identity of the transient proton loading site of the proton-pumping mechanism of cytochrome c oxidase

Kaila, V. R. I., Sharma, V. & Wikstrom, M., 2011, I : Biochimica et Biophysica Acta. Bioenergetics. 1807, s. 80-84 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2010

Redox-coupled proton transfer in the active site of cytochrome cbb(3)

Sharma, V., Wikstrom, M. & Kaila, V. R. I., 2010, I : Biochimica et Biophysica Acta. Bioenergetics. 1797, 8, s. 1512-1520 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2009

Design, synthesis, biological evaluation and molecular modelling studies of novel quinoline derivatives against Mycobacterium tuberculosis

Ram Shankar Upadhayaya, Jaya Kishore Vandavasi, Nageswara Rao Vasireddy, Vivek Sharma, Shailesh S Dixit, Jyoti Chattopadhyaya, 2009, I : Bioorganic & Medicinal Chemistry.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

Ram Shankar Upadhayaya, Girish M Kulkarni, Nageswara Rao Vasireddy, Jaya Kishore Vandavasi, Shailesh S Dixit, Vivek Sharma, Jyoti Chattopadhyaya, 2009, I : Bioorganic & Medicinal Chemistry.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Protein folding as an evolutionary process

Sharma, V., Kaila, V. R. I. & Annila, A., 2009, I : Physica A: Statistical Mechanics and its Applications. 388, 6, s. 851-862 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2008

Cause of Chirality consensus

Jaakkola, S., Sharma, V. & Annila, A., 2008, I : Current Chemical Biology.. 2, 2, s. 153-158 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Modeling the active-site structure of the cbb(3)-type oxidase from Rhodobacter sphaeroides

Sharma, V., Wikstroem, M. & Laakkonen, L., 8 apr 2008, I : Biochemistry. 47, 14, s. 4221-4227 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Modeling the active-site structure of the cbb3-type oxidase from Rhodobacter sphaeroides

Sharma, V., Wikström, M. & Laakkonen, L., 2008, I : Biochemistry. 47, 16, s. 4221-4227 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2007

Natural process - natural selection

Sharma, V. & Annila, A., 2007, I : Biophysical Chemistry. 127, 1-2, s. 123-128 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2006

Sequence analysis of the cbb oxidases and an atomic model for the Rhodobacter sphaeroides enzyme

Sharma, V., Puustinen, A., Wikström, M. & Laakkonen, L., 2006, I : Biochemistry. 45, s. 5754-5765 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review