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Personlig profil

Information om forskning och undervisning

Key research interests

Tissue engineering for drug research

My research focuses on developing functional and predictive cell-based tools for drug research and personalized medicine. We use stem cells- and biomaterials-based tissue engineering approach to produce functional cells and tissues. We have developed flexible, dynamic three-dimensional (3D) culture systems for human pluripotent stem cells (human embryonic stem cells and induced pluripotent stem cells) and human cancer cells. The current specific objective is to generate functional hepatocytes with 3D configuration as drug development tools for drug and chemical testing. We apply advanced cell culture technologies and novel biomaterials, along with molecular biology methods. Our research not only develops new cell-based technologies but also advance fundamental understanding of how matrix and biomaterials affect cell behavior and performance.

https://scholar.google.fi/citations?user=ZrW2FTsAAAAJ&hl=en&oi=ao

Teaching

Cell-biomaterials interactions, pharmaceutical and medical applications (lecture course 590284, 3 credits)

In vitro drug permeability (Advanced biopharmaceutics practicals 590289)

Meritförteckning

Short curriculum vitae

Education

BSc in Pharmacy, School of Pharmacy, West China University of Medical Sciences, Chengdu, China, 1996

PhD in Molecular Endocrinology, Faculty of Medicine, University of Tampere, Finland, 2005

Academic posts

Pharmacist, Institute for Drug Control, Xi'An, China, 1996-1999

Researcher, University of Tampere, Tampere, Finland, 1999-2006

Senior researcher, REGEA Institute for Regenerative Medicine, Tampere, Finland, 2006-2007

Research scientist, A*STAR Institute of Bioengineering and Nanotechnology (IBN), Singapore, 2007-2009

Principal investigator, University of Helsinki, Helsinki, Finland, 2009-

 

Utbildning / akademisk kvalifikation

Biopharmaceutics, Adjunct Professor, Helsingfors universitet

Vetenskapsgrenar

  • 317 Farmaci
  • 314 Hälsovetenskap
  • 311 Basmedicin
  • 1182 Biokemi, cell- och molekylärbiologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 2001 2019

Pluripotent stem cells differentiation towards definitive endoderm

Bogacheva, M., Kanninen, L. & Lou, Y-R., 15 okt 2019, I : Toxicology Letters. 314, s. S186-S187 2 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior

Harjumaki, R., Nugroho, R. W. N., Zhang, X., Lou, Y-R., Yliperttula, M., Valle-Delgado, J. J. & Österberg, M., 14 maj 2019, I : Scientific Reports. 9, 14 s., 7354.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Quantifying the interactions between biomimetic biomaterials - collagen I, collagen IV, laminin 521 and cellulose nanofibrils - by colloidal probe microscopy

Nugroho, R. W. N., Harjumäki, R., Zhang, X., Lou, Y-R., Yliperttula, M., Valle-Delgado, J. J. & Österberg, M., 1 jan 2019, I : Colloids and Surfaces B: Biointerfaces. 173, s. 571-580 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals

Smutný, T., Harjumäki, R., Kanninen, L., Yliperttula, M. L., Pávek, P. & Lou, Y-R., okt 2018, I : Toxicology in Vitro. 52, s. 94-105 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Differences in definitive endoderm induction approaches using growth factors and small molecules

Bogacheva, M. S., Khan, S., Kanninen, L. K., Yliperttula, M., Leung, A. W. & Lou, Y-R., apr 2018, I : Journal of Cellular Physiology. 233, 4, s. 3578-3589 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Projekter 2008 2019

EDUFI-Fellowship / Bystriakova

Lou, Y. & Bystriakova, M.

01/01/201930/09/2019

Projekt: Forskningsprojekt

Stem cell-derived, three-dimensional liver: the missing link in drug discovery

Lou, Y., Harjumäki, R., Kanninen, L., Smutný, T., Bogacheva, M., Salmi, T., Makhdoom, Y. & Taalas, A. P.

SUOMEN AKATEMIA

02/09/201531/12/2016

Projekt: Forskningsprojekt

CIMO Fellowship / Bogacheva

Lou, Y. & Bogacheva, M.

08/04/201530/04/2016

Projekt: Forskningsprojekt

Aktiviteter 2004 2017

Journal of Cellular and Molecular Medicine (Tidskrift)

Yan-Ru Lou (Referentgranskare)
jan 2017

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

npj Regenerative Medicine (Tidskrift)

Yan-Ru Lou (Referentgranskare)
mar 2017

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

keynote speaker

Yan-Ru Lou (!!Keynote speaker)
28 sep 201729 sep 2017

Aktivitet: Typer för tal eller presentation!!Invited talk

Bioscience Reports (Tidskrift)

Yan-Ru Lou (Referentgranskare)
mar 2017

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Bioscience Reports (Tidskrift)

Yan-Ru Lou (Referentgranskare)
maj 2017

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript