Projekt per år
MethodsMicroinfusions of the -opioid receptor antagonist CTOP (0.3 and 1g/site), -opioid receptor agonist DAMGO (0.03 and 0.1g/site), nonselective opioid receptor agonist morphine (30g/site), and -opioid receptor agonist U50488H (0.3 and 1g/site) were administered via bilateral guide cannulas into the nucleus accumbens shell of AA rats that voluntarily consumed 10% EtOH solution in an intermittent, time-restricted (90-minute) 2-bottle choice access paradigm.
ResultsCTOP (1g/site) significantly increased EtOH intake. Conversely, DAMGO resulted in a decreasing trend in EtOH intake. Neither morphine nor U50488H had any effect on EtOH intake in the used paradigm.
ConclusionsThe results provide further evidence for the role of accumbens shell -opioid receptors but not -opioid receptors in mediating reinforcing effects of EtOH and in regulating EtOH consumption. The results also provide support for views suggesting that the nucleus accumbens shell has a major role in mediating EtOH reward.
- 317 Farmaci
The role of opioid receptors in the development of alcohol addiction - Effect of increased and decreased expression on alcohol consumption in Alko Alcohol rats
03/01/2011 → 31/12/2011