Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Olli Dufva; Matti Kankainen; Tiina Kelkka; Nodoka Sekiguchi; Shady Adnan Awad; Samuli Eldfors; Bhagwan Yadav; Heikki Kuusanmäki; Disha Malani; Emma I. Andersson; Paavo Pietarinen; Leena Saikko; Panu E. Kovanen; Teija Ojala; Dean A. Lee; Thomas P. Loughran; Hideyuki Nakazawa; Junji Suzumiya; Ritsuro Suzuki; Young Hyeh Ko; Won Seog Kim; Shih-Sung Chuang; Tero Aittokallio; Wing C. Chan; Koichi Ohshima; Fumihiro Ishida; Satu Mustjoki

doi:10.1038/s41467-018-03987-2

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I. Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh KoWon Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C. Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	1567
Tidskrift	Nature Communications
Volym	9
Antal sidor	12
ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-018-03987-2
Status	Publicerad - 19 apr. 2018
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3122 Cancersjukdomar

Åtkomst av dokument

10.1038/s41467-018-03987-2

AggressiveSlutlig publicerad version, 1,15 MBLicens: CC BY

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Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., Yadav, B., Kuusanmäki, H., Malani, D., Andersson, E. I., Pietarinen, P., Saikko, L., Kovanen, P. E., Ojala, T., Lee, D. A., Loughran, T. P., Nakazawa, H., Suzumiya, J., Suzuki, R., ... Mustjoki, S. (2018). Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. Nature Communications, 9, [1567]. https://doi.org/10.1038/s41467-018-03987-2

Dufva, Olli ; Kankainen, Matti ; Kelkka, Tiina ; Sekiguchi, Nodoka ; Awad, Shady Adnan ; Eldfors, Samuli ; Yadav, Bhagwan ; Kuusanmäki, Heikki ; Malani, Disha ; Andersson, Emma I. ; Pietarinen, Paavo ; Saikko, Leena ; Kovanen, Panu E. ; Ojala, Teija ; Lee, Dean A. ; Loughran, Thomas P. ; Nakazawa, Hideyuki ; Suzumiya, Junji ; Suzuki, Ritsuro ; Ko, Young Hyeh ; Kim, Won Seog ; Chuang, Shih-Sung ; Aittokallio, Tero ; Chan, Wing C. ; Ohshima, Koichi ; Ishida, Fumihiro ; Mustjoki, Satu. / Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. I: Nature Communications. 2018 ; Vol. 9.

@article{336f50439d1d49fead389dafcbc1b5f0,

title = "Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target",

keywords = "EPSTEIN-BARR-VIRUS, DIFFERENTIAL EXPRESSION ANALYSIS, GRANULAR LYMPHOCYTE LEUKEMIA, DNA-SEQUENCING DATA, GAMMA-DELTA-T, NASAL TYPE, NK CELLS, LYMPHOPROLIFERATIVE DISORDERS, MYELOPROLIFERATIVE NEOPLASMS, L-ASPARAGINASE, 3122 Cancers",

author = "Olli Dufva and Matti Kankainen and Tiina Kelkka and Nodoka Sekiguchi and Awad, {Shady Adnan} and Samuli Eldfors and Bhagwan Yadav and Heikki Kuusanm{\"a}ki and Disha Malani and Andersson, {Emma I.} and Paavo Pietarinen and Leena Saikko and Kovanen, {Panu E.} and Teija Ojala and Lee, {Dean A.} and Loughran, {Thomas P.} and Hideyuki Nakazawa and Junji Suzumiya and Ritsuro Suzuki and Ko, {Young Hyeh} and Kim, {Won Seog} and Shih-Sung Chuang and Tero Aittokallio and Chan, {Wing C.} and Koichi Ohshima and Fumihiro Ishida and Satu Mustjoki",

year = "2018",

month = apr,

day = "19",

doi = "10.1038/s41467-018-03987-2",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

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Dufva, O , Kankainen, M , Kelkka, T, Sekiguchi, N, Awad, SA, Eldfors, S, Yadav, B , Kuusanmäki, H, Malani, D, Andersson, EI, Pietarinen, P, Saikko, L, Kovanen, PE, Ojala, T, Lee, DA, Loughran, TP, Nakazawa, H, Suzumiya, J, Suzuki, R, Ko, YH, Kim, WS, Chuang, S-S, Aittokallio, T, Chan, WC, Ohshima, K, Ishida, F & Mustjoki, S 2018, 'Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target', Nature Communications, vol. 9, 1567. https://doi.org/10.1038/s41467-018-03987-2

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. / Dufva, Olli ; Kankainen, Matti ; Kelkka, Tiina; Sekiguchi, Nodoka; Awad, Shady Adnan; Eldfors, Samuli; Yadav, Bhagwan ; Kuusanmäki, Heikki; Malani, Disha; Andersson, Emma I.; Pietarinen, Paavo; Saikko, Leena; Kovanen, Panu E.; Ojala, Teija; Lee, Dean A.; Loughran, Thomas P.; Nakazawa, Hideyuki; Suzumiya, Junji; Suzuki, Ritsuro; Ko, Young Hyeh; Kim, Won Seog; Chuang, Shih-Sung; Aittokallio, Tero; Chan, Wing C.; Ohshima, Koichi; Ishida, Fumihiro; Mustjoki, Satu.

I: Nature Communications, Vol. 9, 1567, 19.04.2018.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

AU - Dufva, Olli

AU - Kankainen, Matti

AU - Kelkka, Tiina

AU - Sekiguchi, Nodoka

AU - Awad, Shady Adnan

AU - Eldfors, Samuli

AU - Yadav, Bhagwan

AU - Kuusanmäki, Heikki

AU - Malani, Disha

AU - Andersson, Emma I.

AU - Pietarinen, Paavo

AU - Saikko, Leena

AU - Kovanen, Panu E.

AU - Ojala, Teija

AU - Lee, Dean A.

AU - Loughran, Thomas P.

AU - Nakazawa, Hideyuki

AU - Suzumiya, Junji

AU - Suzuki, Ritsuro

AU - Ko, Young Hyeh

AU - Kim, Won Seog

AU - Chuang, Shih-Sung

AU - Aittokallio, Tero

AU - Chan, Wing C.

AU - Ohshima, Koichi

AU - Ishida, Fumihiro

AU - Mustjoki, Satu

PY - 2018/4/19

Y1 - 2018/4/19

KW - EPSTEIN-BARR-VIRUS

KW - DIFFERENTIAL EXPRESSION ANALYSIS

KW - GRANULAR LYMPHOCYTE LEUKEMIA

KW - DNA-SEQUENCING DATA

KW - GAMMA-DELTA-T

KW - NASAL TYPE

KW - NK CELLS

KW - LYMPHOPROLIFERATIVE DISORDERS

KW - MYELOPROLIFERATIVE NEOPLASMS

KW - L-ASPARAGINASE

KW - 3122 Cancers

U2 - 10.1038/s41467-018-03987-2

DO - 10.1038/s41467-018-03987-2

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1567

ER -