Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Sharon Y. Geerlings, Ioannis Kostopoulos, Willem M. de Vos, Clara Belzer

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.
Originalspråkengelska
Artikelnummer75
TidskriftMicroorganisms
Volym6
Utgåva3
Antal sidor26
ISSN2076-2607
DOI
StatusPublicerad - 23 jul 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 1183 Växtbiologi, mikrobiologi, virologi
  • 3111 Biomedicinska vetenskaper

Citera det här

Geerlings, Sharon Y. ; Kostopoulos, Ioannis ; de Vos, Willem M. ; Belzer, Clara. / Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?. I: Microorganisms. 2018 ; Vol. 6, Nr. 3.
@article{fc4eacfd63f840859825e858231e117a,
title = "Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?",
abstract = "Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.",
keywords = "1183 Plant biology, microbiology, virology, 3111 Biomedicine",
author = "Geerlings, {Sharon Y.} and Ioannis Kostopoulos and {de Vos}, {Willem M.} and Clara Belzer",
year = "2018",
month = "7",
day = "23",
doi = "10.3390/microorganisms6030075",
language = "English",
volume = "6",
journal = "Microorganisms",
issn = "2076-2607",
publisher = "MDPI",
number = "3",

}

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How? / Geerlings, Sharon Y.; Kostopoulos, Ioannis; de Vos, Willem M.; Belzer, Clara.

I: Microorganisms, Vol. 6, Nr. 3, 75, 23.07.2018.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

AU - Geerlings, Sharon Y.

AU - Kostopoulos, Ioannis

AU - de Vos, Willem M.

AU - Belzer, Clara

PY - 2018/7/23

Y1 - 2018/7/23

N2 - Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.

AB - Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.

KW - 1183 Plant biology, microbiology, virology

KW - 3111 Biomedicine

U2 - 10.3390/microorganisms6030075

DO - 10.3390/microorganisms6030075

M3 - Article

VL - 6

JO - Microorganisms

JF - Microorganisms

SN - 2076-2607

IS - 3

M1 - 75

ER -