All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa; Zehua Liu; João Pedro Martins; Alexandra  Correia; Antti Tuomas Antero Rahikkala; Wei Li; Jani Seitsonen; Janne Ruokolainen; Sami-Pekka Hirvonen; Ana Aguiar- Ricardo; M. Luísa Corvo; Hélder A. Santos

doi:10.1039/D0BM00743A

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa, Zehua Liu, João Pedro Martins, Alexandra Correia, Antti Tuomas Antero Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami-Pekka Hirvonen, Ana Aguiar- Ricardo, M. Luísa Corvo, Hélder A. Santos

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Originalspråk	engelska
Tidskrift	Biomaterials Science
Volym	8
Nummer	12
Sidor (från-till)	3270-3277
Antal sidor	8
ISSN	2047-4830
DOI	https://doi.org/10.1039/D0BM00743A
Status	Publicerad - 21 juni 2020
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

317 Farmaci

Åtkomst av dokument

10.1039/D0BM00743ALicens: CC BY-NC

d0bm00743aSlutlig publicerad version, 2,08 MBLicens: CC BY-NC

Citera det här

Costa, C., Liu, Z., Martins, J. P., Correia, A., Rahikkala, A. T. A., Li, W., Seitsonen, J., Ruokolainen, J., Hirvonen, S-P., Aguiar- Ricardo, A., Corvo, M. L., & Santos, H. A. (2020). All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. Biomaterials Science, 8(12), 3270-3277. https://doi.org/10.1039/D0BM00743A

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title = "All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery",

abstract = "Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.",

keywords = "BARRIER, BILE-SALTS, CELL, CHITOSAN, DRUG-DELIVERY, LIPOSOMES, MOLECULAR-WEIGHT, NANOPARTICLES, STABILITY, VITRO, 317 Pharmacy",

author = "Clarinda Costa and Zehua Liu and Martins, {Jo{\~a}o Pedro} and Alexandra Correia and Rahikkala, {Antti Tuomas Antero} and Wei Li and Jani Seitsonen and Janne Ruokolainen and Sami-Pekka Hirvonen and {Aguiar- Ricardo}, Ana and Corvo, {M. Lu{\'i}sa} and Santos, {H{\'e}lder A.}",

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month = jun,

day = "21",

doi = "10.1039/D0BM00743A",

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T1 - All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

AU - Costa, Clarinda

AU - Liu, Zehua

AU - Martins, João Pedro

AU - Correia, Alexandra

AU - Rahikkala, Antti Tuomas Antero

AU - Li, Wei

AU - Seitsonen, Jani

AU - Ruokolainen, Janne

AU - Hirvonen, Sami-Pekka

AU - Aguiar- Ricardo, Ana

AU - Corvo, M. Luísa

AU - Santos, Hélder A.

PY - 2020/6/21

Y1 - 2020/6/21

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AB - Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

KW - BARRIER

KW - BILE-SALTS

KW - CELL

KW - CHITOSAN

KW - DRUG-DELIVERY

KW - LIPOSOMES

KW - MOLECULAR-WEIGHT

KW - NANOPARTICLES

KW - STABILITY

KW - VITRO

KW - 317 Pharmacy

U2 - 10.1039/D0BM00743A

DO - 10.1039/D0BM00743A

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EP - 3277

JO - Biomaterials Science

JF - Biomaterials Science

SN - 2047-4830

IS - 12

ER -