All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa, Zehua Liu, João Pedro Martins, Alexandra Correia, Antti Tuomas Antero Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami-Pekka Hirvonen, Ana Aguiar- Ricardo, M. Luísa Corvo, Hélder A. Santos

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Originalspråkengelska
TidskriftBiomaterials Science
Volym8
Utgåva12
Sidor (från-till)3270-3277
Antal sidor8
ISSN2047-4830
DOI
StatusPublicerad - 21 jun 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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