Altered Bile Transporter Expression and Cholesterol Metabolism in Children With Cholesterol and Pigment Gallstones

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Objectives: We elucidated pathophysiology of pediatric gallstone disease by assessing liver expression of bile transporters in relation to bile acids and surrogates of cholesterol absorption and synthesis in serum and gallstones. Methods: RNA expression of canalicular bile transporters in liver biopsies from 32 pediatric gallstone patients and from 6 liver donors (controls) was measured by qRT-PCR (quantitative real-time reverse transcription polymerase chain reaction). Concentrations of cholesterol and precursors, plant sterols and bile acids in gallstones, and in serum of the patients and 82 healthy children were measured. Primary outcomes were the difference in RNA expressions and serum sterol profiles between patients and controls. Results: Cholesterol stones (CS; n = 15) contained cholesterol >42% and pigment stones (PS; n = 17)

Originalspråkengelska
TidskriftJournal of Pediatric Gastroenterology and Nutrition
Volym69
Utgåva2
Sidor (från-till)138-144
Antal sidor7
ISSN0277-2116
DOI
StatusPublicerad - aug 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3121 Allmänmedicin, inre medicin och annan klinisk medicin
  • 3123 Kvinno- och barnsjukdomar

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