Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age

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Sammanfattning

Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, preterm-born children performed WM tasks less accurately, had reduced activation in several right prefrontal areas, and weaker deactivation of right temporal lobe areas. The weaker prefrontal activation correlated with poorer WM performance. Preterm-born children had higher fractional anisotropy (FA) and lower diffusivity than controls in several white-matter areas, and in the posterior cerebellum, the higher FA associated with poorer visuospatial test scores. In controls, higher FA and lower diffusivity correlated with faster WM performance. Together these findings demonstrate weaker WM-related brain activations and altered white matter microstructure in children born extremely preterm, who had normal global cognitive ability.
Originalspråkengelska
Artikelnummer103615
TidskriftBrain and Cognition
Volym136
Antal sidor14
ISSN0278-2626
DOI
StatusPublicerad - nov 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 515 Psykologi
  • 3112 Neurovetenskaper
  • 3124 Neurologi och psykiatri

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@article{68855157c6e5411fad74dd9fe81535a3,
title = "Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age",
abstract = "Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, preterm-born children performed WM tasks less accurately, had reduced activation in several right prefrontal areas, and weaker deactivation of right temporal lobe areas. The weaker prefrontal activation correlated with poorer WM performance. Preterm-born children had higher fractional anisotropy (FA) and lower diffusivity than controls in several white-matter areas, and in the posterior cerebellum, the higher FA associated with poorer visuospatial test scores. In controls, higher FA and lower diffusivity correlated with faster WM performance. Together these findings demonstrate weaker WM-related brain activations and altered white matter microstructure in children born extremely preterm, who had normal global cognitive ability.",
keywords = "Working memory, Pediatric imaging, Functional MRI, Diffusion tensor imaging, Prematurity, INCREASED FRACTIONAL ANISOTROPY, ACTIVE PERINATAL-CARE, CHOICE-REACTION TIME, SPATIAL STATISTICS, EXECUTIVE FUNCTION, YOUNG-ADULTS, NEURODEVELOPMENTAL OUTCOMES, DIFFUSION ANISOTROPY, FMRI, ATTENTION, 515 Psychology, 3112 Neurosciences, 3124 Neurology and psychiatry",
author = "Maksym Tokariev and Virve Vuontela and Piia L{\"o}nnberg and Aulikki Lano and Jaana Perkola and Elina Wolford and Sture Andersson and Marjo Mets{\"a}ranta and Synn{\"o}ve Carlson",
year = "2019",
month = "11",
doi = "10.1016/j.bandc.2019.103615",
language = "English",
volume = "136",
journal = "Brain and Cognition",
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publisher = "Academic Press",

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TY - JOUR

T1 - Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age

AU - Tokariev, Maksym

AU - Vuontela, Virve

AU - Lönnberg, Piia

AU - Lano, Aulikki

AU - Perkola, Jaana

AU - Wolford, Elina

AU - Andersson, Sture

AU - Metsäranta, Marjo

AU - Carlson, Synnöve

PY - 2019/11

Y1 - 2019/11

N2 - Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, preterm-born children performed WM tasks less accurately, had reduced activation in several right prefrontal areas, and weaker deactivation of right temporal lobe areas. The weaker prefrontal activation correlated with poorer WM performance. Preterm-born children had higher fractional anisotropy (FA) and lower diffusivity than controls in several white-matter areas, and in the posterior cerebellum, the higher FA associated with poorer visuospatial test scores. In controls, higher FA and lower diffusivity correlated with faster WM performance. Together these findings demonstrate weaker WM-related brain activations and altered white matter microstructure in children born extremely preterm, who had normal global cognitive ability.

AB - Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, preterm-born children performed WM tasks less accurately, had reduced activation in several right prefrontal areas, and weaker deactivation of right temporal lobe areas. The weaker prefrontal activation correlated with poorer WM performance. Preterm-born children had higher fractional anisotropy (FA) and lower diffusivity than controls in several white-matter areas, and in the posterior cerebellum, the higher FA associated with poorer visuospatial test scores. In controls, higher FA and lower diffusivity correlated with faster WM performance. Together these findings demonstrate weaker WM-related brain activations and altered white matter microstructure in children born extremely preterm, who had normal global cognitive ability.

KW - Working memory

KW - Pediatric imaging

KW - Functional MRI

KW - Diffusion tensor imaging

KW - Prematurity

KW - INCREASED FRACTIONAL ANISOTROPY

KW - ACTIVE PERINATAL-CARE

KW - CHOICE-REACTION TIME

KW - SPATIAL STATISTICS

KW - EXECUTIVE FUNCTION

KW - YOUNG-ADULTS

KW - NEURODEVELOPMENTAL OUTCOMES

KW - DIFFUSION ANISOTROPY

KW - FMRI

KW - ATTENTION

KW - 515 Psychology

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

U2 - 10.1016/j.bandc.2019.103615

DO - 10.1016/j.bandc.2019.103615

M3 - Article

VL - 136

JO - Brain and Cognition

JF - Brain and Cognition

SN - 0278-2626

M1 - 103615

ER -