The indigenous presence in urban areas of Amazonia has become more visible as Indian populations have negotiated their own spaces and acted in new contexts previously reserved for the dominant society. This article looks at ways in which today's young Indians in an urban area define and interpret their new cultural and social situations, drawing from research conducted with Apurin, Cashinahua and Manchineri youths in Rio Branco, a city in Acre state, Western Brazil. These young people occupy a variety of “native” and “non-native” habituses and develop their notions of indigeneity within complex social networks as part of their strategy for rupturing the otherness associated with indigeneity. The text contributes to the discussion on the theory of practice and identity politics, as well as embodiment. Young Indians in urban Amazonia constitute their agencies in multiple ways and use various embodiments based in the practices and knowledge of their native groups and those of urban national and global society. The young natives break with the image of Lowland South American Indians as peoples uncontaminated by urban influences and help promote new interactions between native populations in the reserve and the city.