An unusual amino acid substitution within the hummingbird cytochrome c oxidase alters a key proton-conducting channel

Forskningsoutput: ArbetsdokumentVetenskaplig

Sammanfattning

Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous hovering insects, hinting at convergent evolution linked to diet or mode of flight. We performed atomistic molecular dynamics simulations using bovine and hummingbird models, and our findings suggest that COI amino acid position 153 provides genetic control of D-channel hydration and activity. We discuss potential phenotypic outcomes for the hummingbird that are linked to this intriguing instance of positive selection upon the mitochondrial genome.
Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous hovering insects, hinting at convergent evolution linked to diet or mode of flight. We performed atomistic molecular dynamics simulations using bovine and hummingbird models, and our findings suggest that COI amino acid position 153 provides genetic control of D-channel hydration and activity. We discuss potential phenotypic outcomes for the hummingbird that are linked to this intriguing instance of positive selection upon the mitochondrial genome.
Originalspråkengelska
FörlagbioRxiv
DOI
StatusPublicerad - 2019
MoE-publikationstypD4 Publicerad utvecklings- eller forskningsrapport eller studie

Citera det här

@techreport{49bb226bb21c4b31a3491f8b1db9efd3,
title = "An unusual amino acid substitution within the hummingbird cytochrome c oxidase alters a key proton-conducting channel",
abstract = "Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous hovering insects, hinting at convergent evolution linked to diet or mode of flight. We performed atomistic molecular dynamics simulations using bovine and hummingbird models, and our findings suggest that COI amino acid position 153 provides genetic control of D-channel hydration and activity. We discuss potential phenotypic outcomes for the hummingbird that are linked to this intriguing instance of positive selection upon the mitochondrial genome.",
author = "Dunn, {Cory David} and Vivek Sharma",
year = "2019",
doi = "10.1101/610915",
language = "English",
publisher = "bioRxiv",
address = "International",
type = "WorkingPaper",
institution = "bioRxiv",

}

TY - UNPB

T1 - An unusual amino acid substitution within the hummingbird cytochrome c oxidase alters a key proton-conducting channel

AU - Dunn, Cory David

AU - Sharma, Vivek

PY - 2019

Y1 - 2019

N2 - Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous hovering insects, hinting at convergent evolution linked to diet or mode of flight. We performed atomistic molecular dynamics simulations using bovine and hummingbird models, and our findings suggest that COI amino acid position 153 provides genetic control of D-channel hydration and activity. We discuss potential phenotypic outcomes for the hummingbird that are linked to this intriguing instance of positive selection upon the mitochondrial genome.

AB - Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous hovering insects, hinting at convergent evolution linked to diet or mode of flight. We performed atomistic molecular dynamics simulations using bovine and hummingbird models, and our findings suggest that COI amino acid position 153 provides genetic control of D-channel hydration and activity. We discuss potential phenotypic outcomes for the hummingbird that are linked to this intriguing instance of positive selection upon the mitochondrial genome.

U2 - 10.1101/610915

DO - 10.1101/610915

M3 - Working paper

BT - An unusual amino acid substitution within the hummingbird cytochrome c oxidase alters a key proton-conducting channel

PB - bioRxiv

ER -