Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd.

S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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: The present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of Mikania scandens (L.) Willd. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg kg−1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg−1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). The extract was also investigated for its antioxidant action using 1,1-Di-Phenyl-2-Picryl-Hydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL−1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL−1. The IC50 values of the extract and ascorbic acid were 220.43μg mL−1 and 125.10 μg mL−1, respectively in NO scavenging assay. The findings of the study suggest that the extract from Mikania scandens has strong analgesic and antioxidant effects.
Originalspråkengelska
TidskriftAmerican Journal of Pharmacology and Toxicology
Volym4
Utgåva1
Sidor (från-till)1-7
ISSN1557-4962
StatusPublicerad - 2009
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 119 Övrig naturvetenskap

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S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman. (2009). Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd. American Journal of Pharmacology and Toxicology, 4(1), 1-7.
S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman. . / Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd. I: American Journal of Pharmacology and Toxicology. 2009 ; Vol. 4, Nr. 1. s. 1-7.
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title = "Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd.",
abstract = ": The present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of Mikania scandens (L.) Willd. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg kg−1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg−1) produced a maximum of 53.73{\%} inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76{\%}). The extract was also investigated for its antioxidant action using 1,1-Di-Phenyl-2-Picryl-Hydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL−1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL−1. The IC50 values of the extract and ascorbic acid were 220.43μg mL−1 and 125.10 μg mL−1, respectively in NO scavenging assay. The findings of the study suggest that the extract from Mikania scandens has strong analgesic and antioxidant effects.",
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S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman. 2009, 'Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd.', American Journal of Pharmacology and Toxicology, vol. 4, nr. 1, s. 1-7.

Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd. / S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman. .

I: American Journal of Pharmacology and Toxicology, Vol. 4, Nr. 1, 2009, s. 1-7.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd.

AU - Majumder, Muntasir Mamun

AU - S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman.

PY - 2009

Y1 - 2009

N2 - : The present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of Mikania scandens (L.) Willd. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg kg−1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg−1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). The extract was also investigated for its antioxidant action using 1,1-Di-Phenyl-2-Picryl-Hydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL−1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL−1. The IC50 values of the extract and ascorbic acid were 220.43μg mL−1 and 125.10 μg mL−1, respectively in NO scavenging assay. The findings of the study suggest that the extract from Mikania scandens has strong analgesic and antioxidant effects.

AB - : The present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of Mikania scandens (L.) Willd. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 250 and 500 mg kg−1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg−1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). The extract was also investigated for its antioxidant action using 1,1-Di-Phenyl-2-Picryl-Hydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL−1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL−1. The IC50 values of the extract and ascorbic acid were 220.43μg mL−1 and 125.10 μg mL−1, respectively in NO scavenging assay. The findings of the study suggest that the extract from Mikania scandens has strong analgesic and antioxidant effects.

KW - 119 Other natural sciences

KW - NATURAL PRODUCTS

M3 - Article

VL - 4

SP - 1

EP - 7

JO - American Journal of Pharmacology and Toxicology

JF - American Journal of Pharmacology and Toxicology

SN - 1557-4962

IS - 1

ER -

S. M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana , and Shafiqur Rahman. . Analgesic and Antioxidant Potential of the Leaves of Mikania scandens (L.) Willd. American Journal of Pharmacology and Toxicology. 2009;4(1):1-7.