Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

Kalle Sakari Lintinen, Sanna Luiro, Patricia Figueiredo, Ekaterina Sakarinen, Zekra Mousavi, Jani Seitsonen, Guillaume N. S. Rivière, Ulriika Mattinen, Matti Niemelä, Päivi Tammela, Monika Österberg, Leena-Sisko Johansson, Johan Bobacka, Hélder A. Santos, Mauri A. Kostiainen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Acid-precipitated lignin nanoparticles with a cationic polymer coating exhibit antibacterial activity when infused with silver. While the use of such particles would be beneficial due to their high antibacterial activity with a low silver content, their production holds steps that are difficult to scale up to inexpensive industrial manufacture. For example, the production of acid-precipitated lignin nanoparticles requires the use of ethylene glycol, which is not easily recycled. Furthermore, the binding of silver to these particles is weak, and thus the particles need to be used rapidly after preparation. Here, we show that with a deprotonation reaction of an organic solution of anhydrous lignin and subsequent ion exchange with silver nitrate and colloid formation by solvent exchange, highly spherical silver carboxylate colloidal lignin particles (AgCLPs) can be prepared. Silver is not released from the particles in deionized water but can be released in physiological conditions, shown by their high antibacterial efficacy with low silver loading. In comparison to lignin nanoparticles with weakly bound silver, AgCLPs have high antibacterial activity even without cationic polyelectrolyte coating, and they retain their antibacterial activity for days. While the rapid depletion of silver from silver-infused lignin nanoparticles can be considered beneficial for some applications, the sustained antibacterial activity of the AgCLPs with ionically bound silver will enable their use in applications where silver nanoparticles have been previously used. Our results demonstrate that CLPs, which can be produced with a closed cycle process on a large scale, can be rapidly and quantitatively functionalized into active materials.
Originalspråkengelska
TidskriftACS Sustainable Chemistry & Engineering
Volym7
Utgåva18
Sidor (från-till)15297-15303
Antal sidor7
ISSN2168-0485
DOI
StatusPublicerad - 16 sep 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 116 Kemi

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Sakari Lintinen, K., Luiro, S., Figueiredo, P., Sakarinen, E., Mousavi, Z., Seitsonen, J., ... A. Kostiainen, M. (2019). Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange. ACS Sustainable Chemistry & Engineering, 7(18), 15297-15303. https://doi.org/10.1021/acssuschemeng.9b02498
Sakari Lintinen, Kalle ; Luiro, Sanna ; Figueiredo, Patricia ; Sakarinen, Ekaterina ; Mousavi, Zekra ; Seitsonen, Jani ; N. S. Rivière, Guillaume ; Mattinen, Ulriika ; Niemelä, Matti ; Tammela, Päivi ; Österberg, Monika ; Johansson, Leena-Sisko ; Bobacka, Johan ; Santos, Hélder A. ; A. Kostiainen, Mauri. / Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange. I: ACS Sustainable Chemistry & Engineering. 2019 ; Vol. 7, Nr. 18. s. 15297-15303.
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title = "Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange",
abstract = "Acid-precipitated lignin nanoparticles with a cationic polymer coating exhibit antibacterial activity when infused with silver. While the use of such particles would be beneficial due to their high antibacterial activity with a low silver content, their production holds steps that are difficult to scale up to inexpensive industrial manufacture. For example, the production of acid-precipitated lignin nanoparticles requires the use of ethylene glycol, which is not easily recycled. Furthermore, the binding of silver to these particles is weak, and thus the particles need to be used rapidly after preparation. Here, we show that with a deprotonation reaction of an organic solution of anhydrous lignin and subsequent ion exchange with silver nitrate and colloid formation by solvent exchange, highly spherical silver carboxylate colloidal lignin particles (AgCLPs) can be prepared. Silver is not released from the particles in deionized water but can be released in physiological conditions, shown by their high antibacterial efficacy with low silver loading. In comparison to lignin nanoparticles with weakly bound silver, AgCLPs have high antibacterial activity even without cationic polyelectrolyte coating, and they retain their antibacterial activity for days. While the rapid depletion of silver from silver-infused lignin nanoparticles can be considered beneficial for some applications, the sustained antibacterial activity of the AgCLPs with ionically bound silver will enable their use in applications where silver nanoparticles have been previously used. Our results demonstrate that CLPs, which can be produced with a closed cycle process on a large scale, can be rapidly and quantitatively functionalized into active materials.",
keywords = "DELIVERY, NANOPARTICLES, antibacterial, colloid, lignin, particle, silver, 116 Chemical sciences",
author = "{Sakari Lintinen}, Kalle and Sanna Luiro and Patricia Figueiredo and Ekaterina Sakarinen and Zekra Mousavi and Jani Seitsonen and {N. S. Rivi{\`e}re}, Guillaume and Ulriika Mattinen and Matti Niemel{\"a} and P{\"a}ivi Tammela and Monika {\"O}sterberg and Leena-Sisko Johansson and Johan Bobacka and Santos, {H{\'e}lder A.} and {A. Kostiainen}, Mauri",
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language = "English",
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Sakari Lintinen, K, Luiro, S, Figueiredo, P, Sakarinen, E, Mousavi, Z, Seitsonen, J, N. S. Rivière, G, Mattinen, U, Niemelä, M, Tammela, P, Österberg, M, Johansson, L-S, Bobacka, J, Santos, HA & A. Kostiainen, M 2019, 'Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange', ACS Sustainable Chemistry & Engineering, vol. 7, nr. 18, s. 15297-15303. https://doi.org/10.1021/acssuschemeng.9b02498

Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange. / Sakari Lintinen, Kalle; Luiro, Sanna; Figueiredo, Patricia; Sakarinen, Ekaterina; Mousavi, Zekra ; Seitsonen, Jani; N. S. Rivière, Guillaume; Mattinen, Ulriika; Niemelä, Matti ; Tammela, Päivi; Österberg, Monika; Johansson, Leena-Sisko; Bobacka, Johan; Santos, Hélder A.; A. Kostiainen, Mauri.

I: ACS Sustainable Chemistry & Engineering, Vol. 7, Nr. 18, 16.09.2019, s. 15297-15303.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

AU - Sakari Lintinen, Kalle

AU - Luiro, Sanna

AU - Figueiredo, Patricia

AU - Sakarinen, Ekaterina

AU - Mousavi, Zekra

AU - Seitsonen, Jani

AU - N. S. Rivière, Guillaume

AU - Mattinen, Ulriika

AU - Niemelä, Matti

AU - Tammela, Päivi

AU - Österberg, Monika

AU - Johansson, Leena-Sisko

AU - Bobacka, Johan

AU - Santos, Hélder A.

AU - A. Kostiainen, Mauri

PY - 2019/9/16

Y1 - 2019/9/16

N2 - Acid-precipitated lignin nanoparticles with a cationic polymer coating exhibit antibacterial activity when infused with silver. While the use of such particles would be beneficial due to their high antibacterial activity with a low silver content, their production holds steps that are difficult to scale up to inexpensive industrial manufacture. For example, the production of acid-precipitated lignin nanoparticles requires the use of ethylene glycol, which is not easily recycled. Furthermore, the binding of silver to these particles is weak, and thus the particles need to be used rapidly after preparation. Here, we show that with a deprotonation reaction of an organic solution of anhydrous lignin and subsequent ion exchange with silver nitrate and colloid formation by solvent exchange, highly spherical silver carboxylate colloidal lignin particles (AgCLPs) can be prepared. Silver is not released from the particles in deionized water but can be released in physiological conditions, shown by their high antibacterial efficacy with low silver loading. In comparison to lignin nanoparticles with weakly bound silver, AgCLPs have high antibacterial activity even without cationic polyelectrolyte coating, and they retain their antibacterial activity for days. While the rapid depletion of silver from silver-infused lignin nanoparticles can be considered beneficial for some applications, the sustained antibacterial activity of the AgCLPs with ionically bound silver will enable their use in applications where silver nanoparticles have been previously used. Our results demonstrate that CLPs, which can be produced with a closed cycle process on a large scale, can be rapidly and quantitatively functionalized into active materials.

AB - Acid-precipitated lignin nanoparticles with a cationic polymer coating exhibit antibacterial activity when infused with silver. While the use of such particles would be beneficial due to their high antibacterial activity with a low silver content, their production holds steps that are difficult to scale up to inexpensive industrial manufacture. For example, the production of acid-precipitated lignin nanoparticles requires the use of ethylene glycol, which is not easily recycled. Furthermore, the binding of silver to these particles is weak, and thus the particles need to be used rapidly after preparation. Here, we show that with a deprotonation reaction of an organic solution of anhydrous lignin and subsequent ion exchange with silver nitrate and colloid formation by solvent exchange, highly spherical silver carboxylate colloidal lignin particles (AgCLPs) can be prepared. Silver is not released from the particles in deionized water but can be released in physiological conditions, shown by their high antibacterial efficacy with low silver loading. In comparison to lignin nanoparticles with weakly bound silver, AgCLPs have high antibacterial activity even without cationic polyelectrolyte coating, and they retain their antibacterial activity for days. While the rapid depletion of silver from silver-infused lignin nanoparticles can be considered beneficial for some applications, the sustained antibacterial activity of the AgCLPs with ionically bound silver will enable their use in applications where silver nanoparticles have been previously used. Our results demonstrate that CLPs, which can be produced with a closed cycle process on a large scale, can be rapidly and quantitatively functionalized into active materials.

KW - DELIVERY

KW - NANOPARTICLES

KW - antibacterial

KW - colloid

KW - lignin

KW - particle

KW - silver

KW - 116 Chemical sciences

U2 - 10.1021/acssuschemeng.9b02498

DO - 10.1021/acssuschemeng.9b02498

M3 - Article

VL - 7

SP - 15297

EP - 15303

JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

SN - 2168-0485

IS - 18

ER -