Autophagy

supporting cellular and organismal homeostasis by self-eating

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.
Originalspråkengelska
TidskriftInternational Journal of Biochemistry & Cell Biology
Volym111
Sidor (från-till)1-10
Antal sidor10
ISSN1357-2725
DOI
StatusPublicerad - jun 2019
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi

Citera det här

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title = "Autophagy: supporting cellular and organismal homeostasis by self-eating",
abstract = "Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.",
keywords = "1182 Biochemistry, cell and molecular biology, autophagy, aging, stem cells, immunity, Inflammation, neurodegeneration, cancer",
author = "Eeva-Liisa Eskelinen",
year = "2019",
month = "6",
doi = "10.1016/j.biocel.2019.03.010",
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volume = "111",
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journal = "International Journal of Biochemistry & Cell Biology",
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Autophagy : supporting cellular and organismal homeostasis by self-eating. / Eskelinen, Eeva-Liisa.

I: International Journal of Biochemistry & Cell Biology, Vol. 111, 06.2019, s. 1-10.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

TY - JOUR

T1 - Autophagy

T2 - supporting cellular and organismal homeostasis by self-eating

AU - Eskelinen, Eeva-Liisa

PY - 2019/6

Y1 - 2019/6

N2 - Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.

AB - Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.

KW - 1182 Biochemistry, cell and molecular biology

KW - autophagy

KW - aging

KW - stem cells

KW - immunity

KW - Inflammation

KW - neurodegeneration

KW - cancer

U2 - 10.1016/j.biocel.2019.03.010

DO - 10.1016/j.biocel.2019.03.010

M3 - Review Article

VL - 111

SP - 1

EP - 10

JO - International Journal of Biochemistry & Cell Biology

JF - International Journal of Biochemistry & Cell Biology

SN - 1357-2725

ER -