Sammanfattning
Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product. The method examined small-scale particulate solids in motion and related behaviour at the particle–particle interfaces under varying shear conditions. The study correlated the lubricant-free area of powder particles with the effective bonding area during compaction. On the particle surface, shear microdynamics characterized the dynamic friction between particles. This described for the first time the extent of the lubricant coverage in powders, which was also related to the magnitude of the shear forces during blending and amount of MgSt. In addition, compression studies described the stress applied to tablets and processing equipment. The combination of knowledge gained on a laboratory scale determined the critical process parameter ranges and control points between under- and overlubrication.
Originalspråk | engelska |
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Artikelnummer | 118337 |
Tidskrift | Powder Technology |
Volym | 419 |
Antal sidor | 8 |
ISSN | 0032-5910 |
DOI | |
Status | Publicerad - 1 apr. 2023 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |
Vetenskapsgrenar
- 317 Farmaci