Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland

Riikka Hänninen, Aada Murtomäki, Fanni Svärd, Aarno Dietz, Paulus Torkki, Jari Haukka, Mikko Nuutinen, Sanna Toppila-Salmi

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Background: Our population-based study has previously shown that being born in winter or spring was associated with adult-onset asthma. The aim was to study if season of birth (SOB) is associated with airway allergy and related diseases: NSAID exacerbated respiratory disease (N-ERD), asthma, allergic rhinitis (AR), nonallergic rhinitis (NAR), chronic rhinosinusitis with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) in Finland. Methods: A randomly sampled retrospective registry-based follow-up data (n = 74,868) of patients visiting Hospital District of Helsinki and Uusimaa (HUS) in Finland was used. The birth date, sex, visit date and comorbidities were collected from electronic health record data during visits from 2005 to 2019. Results: The mean (SD, range) age of the sample was 34.53 (25.47, 0–102) years, with 48.7 % being men. We divided the whole population in four groups based on the season they were born (SOB-groups). When observing these four SOB-groups, the proportion of those having asthma was 43.1%, 42.1%, 41.1%, 42.7%, in winter, spring, summer, and autumn SOB-groups, respectively. The proportion of those having AR was 12.6%, 12.0%, 10.7%, 12.1%, respectively. When having summer as a reference, being born in any other time of year was significantly associated with AR and, being born in autumn or winter was associated with asthma. No significant association was observed in CRS or N-ERD or NAR groups in adjusted models. Conclusions: The study suggests that early life immunological events may have a role a role in pathogenesis of asthma and AR. As no association was observed between SOB and CRSsNP, CRSwNP, N-ERD or NAR, further studies on this are warranted.

Originalspråkengelska
Artikelnummere12383
TidskriftClinical and Translational Allergy
Volym14
Nummer7
Antal sidor5
ISSN2045-7022
DOI
StatusPublicerad - juli 2024
MoE-publikationstypA1 Tidskriftsartikel-refererad

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Publisher Copyright:
© 2024 The Author(s). Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

Vetenskapsgrenar

  • 3121 Allmänmedicin, inre medicin och annan klinisk medicin

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