Botulinum neurotoxin risks and detection in environment, agriculture and food chains

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Sammanfattning

Botulinum neurotoxin (BoNT) is produced by the anaerobic bacterium Clostridium botulinum during its vegetative growth. C. botulinum strains are commonly found in the environment, animals and in food raw materials. The bacterium forms dormant endospores, which do not produce toxins. However, the spores are highly resistant to environmental stress and thus maintain the toxic potential in environmental and agricultural systems and the food chains that occasionally provide conditions favourable for spore germination and outgrowth into a toxic culture. Besides causing botulism to man and animals, BoNTs are widely exploited by medical industries in treatment of spastic diseases. Thoroughly validated, sensitive and specific assays for neurotoxin detection are thus needed not only for laboratory diagnostics of botulism outbreaks but also for potency testing of the pharmaceutical neurotoxin products.

Originalspråkengelska
Titel på gästpublikationMolecular Aspects of Botulinum Neurotoxin
RedaktörerKeith Alan Foster
Antal sidor30
UtgivningsortNew York
FörlagSpringer
Utgivningsdatum2014
Sidor229-258
ISBN (tryckt)978-1-4614-9453-9
ISBN (elektroniskt)978-1-4614-9454-6
DOI
StatusPublicerad - 2014
MoE-publikationstypA3 Del av bok eller annan forskningsbok

Publikationsserier

NamnCurrent Topics in Neurotoxicity
Volym4

Vetenskapsgrenar

  • 413 Veterinärvetenskap

Citera det här

Lindström, M., Keto-Timonen, R., & Korkeala, H. (2014). Botulinum neurotoxin risks and detection in environment, agriculture and food chains. I K. A. Foster (Red.), Molecular Aspects of Botulinum Neurotoxin (s. 229-258). (Current Topics in Neurotoxicity; Vol. 4). Springer. https://doi.org/10.1007/978-1-4614-9454-6