BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Yuexi Gu; Mikko Helenius; Kristiina Vaananen; Daria Bulanova; Jani Saarela; Anna Sokolenko; John Martens; Evgeny Imyanitov; Sergey Kuznetsov

doi:10.1038/srep28217

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Yuexi Gu, Mikko Helenius, Kristiina Vaananen, Daria Bulanova, Jani Saarela, Anna Sokolenko, John Martens, Evgeny Imyanitov, Sergey Kuznetsov

Institutet för molekylärmedicin i Finland

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	28217
Tidskrift	Scientific Reports
Volym	6
Antal sidor	9
ISSN	2045-2322
DOI	https://doi.org/10.1038/srep28217
Status	Publicerad - 17 juni 2016
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3111 Biomedicinska vetenskaper

Åtkomst av dokument

10.1038/srep28217

BRCA1Slutlig publicerad version, 1,43 MBLicens: CC BY

FIMM High Throughput Biomedicine Unit
Päivi Tammela (Chef)
Institutet för molekylärmedicin i Finland
Utrustning/facilitet: Central servicefacilitet

Citera det här

@article{6f612ba8fc1f440f85fe44f8fd08a967,

title = "BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine",

keywords = "DNA-DAMAGE RESPONSE, EMBRYONIC LETHALITY, UBIQUITIN LIGASE, MISMATCH REPAIR, BRCA1, MICE, IDENTIFICATION, TUMORIGENESIS, ARRY-142886, INSTABILITY, 3111 Biomedicine",

author = "Yuexi Gu and Mikko Helenius and Kristiina Vaananen and Daria Bulanova and Jani Saarela and Anna Sokolenko and John Martens and Evgeny Imyanitov and Sergey Kuznetsov",

year = "2016",

month = jun,

day = "17",

doi = "10.1038/srep28217",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

AU - Gu, Yuexi

AU - Helenius, Mikko

AU - Vaananen, Kristiina

AU - Bulanova, Daria

AU - Saarela, Jani

AU - Sokolenko, Anna

AU - Martens, John

AU - Imyanitov, Evgeny

AU - Kuznetsov, Sergey

PY - 2016/6/17

Y1 - 2016/6/17

KW - DNA-DAMAGE RESPONSE

KW - EMBRYONIC LETHALITY

KW - UBIQUITIN LIGASE

KW - MISMATCH REPAIR

KW - BRCA1

KW - MICE

KW - IDENTIFICATION

KW - TUMORIGENESIS

KW - ARRY-142886

KW - INSTABILITY

KW - 3111 Biomedicine

U2 - 10.1038/srep28217

DO - 10.1038/srep28217

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 28217

ER -

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Vetenskapsgrenar

Åtkomst av dokument

Utrustning

FIMM High Throughput Biomedicine Unit

Citera det här