Building an Open Source Classifier for the Neonatal EEG Background: A Systematic Feature-Based Approach From Expert Scoring to Clinical Visualization

Saeed Montazeri Moghadam, Elana Pinchefsky, Ilse Tse, Viviana Marchi, Jukka Kohonen, Minna Kauppila, Manu Airaksinen, Karoliina Tapani, Päivi Nevalainen, Cecil Hahn, Emily W. Y. Tam, Nathan J. Stevenson, Sampsa Vanhatalo

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Sammanfattning

Neonatal brain monitoring in the neonatal intensive care units (NICU) requires a continuous review of the spontaneous cortical activity, i.e., the electroencephalograph (EEG) background activity. This needs development of bedside methods for an automated assessment of the EEG background activity. In this paper, we present development of the key components of a neonatal EEG background classifier, starting from the visual background scoring to classifier design, and finally to possible bedside visualization of the classifier results. A dataset with 13,200 5-minute EEG epochs (8–16 channels) from 27 infants with birth asphyxia was used for classifier training after scoring by two independent experts. We tested three classifier designs based on 98 computational features, and their performance was assessed with respect to scoring system, pre- and post-processing of labels and outputs, choice of channels, and visualization in monitor displays. The optimal solution achieved an overall classification accuracy of 97% with a range across subjects of 81–100%. We identified a set of 23 features that make the classifier highly robust to the choice of channels and missing data due to artefact rejection. Our results showed that an automated bedside classifier of EEG background is achievable, and we publish the full classifier algorithm to allow further clinical replication and validation studies.
Originalspråkengelska
Artikelnummer675154
TidskriftFrontiers in Human Neuroscience
Volym15
Antal sidor15
ISSN1662-5161
DOI
StatusPublicerad - 31 maj 2021
MoE-publikationstypA1 Tidskriftsartikel-refererad

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  • 217 Medicinsk teknik

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