Sammanfattning

Anogeissus leiocarpus occurs in savannas in tropical and subtropical regions of Africa and is used among traditional medicinal practitioners for treatment of various diseases, among them bacterial infections [1]. Eight flavonoids [2], methyl ellagic acid, ellagic acid [4, 5] and the ellagitannins castalagin and flagallonic acid [6] have been reported from the leaves and bark of A. leiocarpus. There are just a few investigations on the phytochemistry of the roots [1], however. This study has aimed on in depth investigations on the phytochemistry of the root part. Ten microliters of 50 mg/ml methanol extract of the root of A. leiocarpus was applied on RP18 TLC reversed phase. Methanol, water and orthophosphoric acid were used as mobile phase. DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent was used for detecting antioxidative compounds. In order to identify these compounds HPLC-DAD and UHPLC/MS/QTOF methods [3] were used. Aromadendrin, taxifolin, methyltaxifolin, ampelopsin and eriodictyol as well as pinosylvin and methylpinosylvin and 3,3´-Di-O-methyl ellagic acid glucoside were identified for the first time in the roots of A. leiocarpus. In addition pentagalloyglucose and digalloylglucose were found in the root. We have demonstrated that a methanolic root extract of A. leiocarpus gives promising antibacterial effects. These effects might be connected to antioxidative flavonoids and ellagic acid derivatives in this extract
Originalspråkengelska
Titel på gästpublikationPlanta Medica
Volym81 - PM_77
FörlagGeorg Thieme Verlag
Utgivningsdatum2015
DOI
StatusPublicerad - 2015
MoE-publikationstypA4 Artikel i en konferenspublikation

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