Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu; Yunzhan  Li; Wei Li; Wenhua Lian; Marianna Kemell; Sami Hietala; Patricia Figueiredo; Li Li; Ermei Mäkilä; Ming  Ma; Jarno Salonen; Jouni T. Hirvonen; Dongfei Liu; Hongbo Zhang; Xianming  Deng; Helder A. Santos

doi:10.1039/c8mh01145a

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patricia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Helder A. Santos

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Originalspråk	engelska
Tidskrift	Materials Horizons
Volym	6
Nummer	2
Sidor (från-till)	385-393
Antal sidor	9
ISSN	2051-6347
DOI	https://doi.org/10.1039/c8mh01145a
Status	Publicerad - 1 feb. 2019
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

116 Kemi
317 Farmaci

Åtkomst av dokument

10.1039/c8mh01145aLicens: CC BY-NC

c8mh01145aSlutlig publicerad version, 3,94 MBLicens: CC BY-NC

Citera det här

Liu, Z., Li, Y., Li, W., Lian, W., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D., Zhang, H., Deng, X., & Santos, H. A. (2019). Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing. Materials Horizons, 6(2), 385-393. https://doi.org/10.1039/c8mh01145a

@article{f9441f29f7de4b1fa7a11e3c4d0f91ad,

title = "Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing",

abstract = "Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.",

keywords = "OXIDIZED DEXTRAN, NANOPARTICLES, ANGIOGENESIS, VEGF, DEFEROXAMINE, HYDROGEL, GEL, EXPRESSION, DELIVERY, RELEASE, 116 Chemical sciences, 317 Pharmacy",

author = "Zehua Liu and Yunzhan Li and Wei Li and Wenhua Lian and Marianna Kemell and Sami Hietala and Patricia Figueiredo and Li Li and Ermei M{\"a}kil{\"a} and Ming Ma and Jarno Salonen and Hirvonen, {Jouni T.} and Dongfei Liu and Hongbo Zhang and Xianming Deng and Santos, {Helder A.}",

year = "2019",

month = feb,

day = "1",

doi = "10.1039/c8mh01145a",

language = "English",

volume = "6",

pages = "385--393",

journal = "Materials Horizons",

issn = "2051-6347",

publisher = "Royal Society of Chemistry",

number = "2",

}

Liu, Z, Li, Y, Li, W, Lian, W, Kemell, M , Hietala, S , Figueiredo, P, Li, L, Mäkilä, E, Ma, M, Salonen, J, Hirvonen, JT, Liu, D, Zhang, H, Deng, X & Santos, HA 2019, 'Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing', Materials Horizons, vol. 6, nr. 2, s. 385-393. https://doi.org/10.1039/c8mh01145a

TY - JOUR

T1 - Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

AU - Liu, Zehua

AU - Li, Yunzhan

AU - Li, Wei

AU - Lian, Wenhua

AU - Kemell, Marianna

AU - Hietala, Sami

AU - Figueiredo, Patricia

AU - Li, Li

AU - Mäkilä, Ermei

AU - Ma, Ming

AU - Salonen, Jarno

AU - Hirvonen, Jouni T.

AU - Liu, Dongfei

AU - Zhang, Hongbo

AU - Deng, Xianming

AU - Santos, Helder A.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

AB - Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

KW - OXIDIZED DEXTRAN

KW - NANOPARTICLES

KW - ANGIOGENESIS

KW - VEGF

KW - DEFEROXAMINE

KW - HYDROGEL

KW - GEL

KW - EXPRESSION

KW - DELIVERY

KW - RELEASE

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1039/c8mh01145a

DO - 10.1039/c8mh01145a

M3 - Article

SN - 2051-6347

VL - 6

SP - 385

EP - 393

JO - Materials Horizons

JF - Materials Horizons

IS - 2

ER -