Common genetic variation drives molecular heterogeneity in human iPSCs

Helena Kilpinen; Angela Goncalves; Andreas Leha; Vackar Afzal; Kaur Alasoo; Sofie Ashford; Sendu Bala; Dalila Bensaddek; Francesco Paolo Casale; Oliver J. C. Ulley; Petr Danecek; Adam Faulconbridge; Peter W. Harrison; Annie Kathuria; Davis McCarthy; Shane A. McCarthy; Ruta Meleckyte; Yasin Memari; Nathalie Moens; Filipa Soares; Alice Mann; Ian Streeter; Chukwuma A. Agu; Alex Alderton; Rachel Nelson; Sarah Harper; Minal Patel; Alistair White; Sharad R. Patel; Laura Clarke; Reena Halai; Christopher M. Kirton; Anja Kolb-Kokocinski; Philip Beales; Ewan Birney; Davide Danovi; Angus I. Lamond; Willem H. Ouwehand; Ludovic Vallier; Fiona M. Watt; Richard Durbin; Oliver Stegle; Daniel J. Gaffney

doi:10.1038/nature22403

Common genetic variation drives molecular heterogeneity in human iPSCs

Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J. C. Ulley, Petr Danecek, Adam Faulconbridge, Peter W. Harrison, Annie Kathuria, Davis McCarthy, Shane A. McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa SoaresAlice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal Patel, Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher M. Kirton, Anja Kolb-Kokocinski, Philip Beales, Ewan Birney, Davide Danovi, Angus I. Lamond, Willem H. Ouwehand, Ludovic Vallier, Fiona M. Watt, Richard Durbin, Oliver Stegle, Daniel J. Gaffney

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Nature
Volym	546
Nummer	7658
Sidor (från-till)	370-+
Antal sidor	23
ISSN	0028-0836
DOI	https://doi.org/10.1038/nature22403
Status	Publicerad - 15 juni 2017
Externt publicerad	Ja
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Åtkomst av dokument

10.1038/nature22403

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Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Ulley, O. J. C., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., ... Gaffney, D. J. (2017). Common genetic variation drives molecular heterogeneity in human iPSCs. Nature, 546(7658), 370-+. https://doi.org/10.1038/nature22403

@article{4746dc9d89a44ff587c37509268932fd,

title = "Common genetic variation drives molecular heterogeneity in human iPSCs",

keywords = "PLURIPOTENT STEM-CELLS, GENOME-WIDE ASSOCIATION, CANCER RISK LOCI, SUSCEPTIBILITY LOCI, COPY NUMBER, BREAST-CANCER, DNA METHYLATION, MULTIPLE COMMON, CELIAC-DISEASE, EXPRESSION",

author = "Helena Kilpinen and Angela Goncalves and Andreas Leha and Vackar Afzal and Kaur Alasoo and Sofie Ashford and Sendu Bala and Dalila Bensaddek and Casale, {Francesco Paolo} and Ulley, {Oliver J. C.} and Petr Danecek and Adam Faulconbridge and Harrison, {Peter W.} and Annie Kathuria and Davis McCarthy and McCarthy, {Shane A.} and Ruta Meleckyte and Yasin Memari and Nathalie Moens and Filipa Soares and Alice Mann and Ian Streeter and Agu, {Chukwuma A.} and Alex Alderton and Rachel Nelson and Sarah Harper and Minal Patel and Alistair White and Patel, {Sharad R.} and Laura Clarke and Reena Halai and Kirton, {Christopher M.} and Anja Kolb-Kokocinski and Philip Beales and Ewan Birney and Davide Danovi and Lamond, {Angus I.} and Ouwehand, {Willem H.} and Ludovic Vallier and Watt, {Fiona M.} and Richard Durbin and Oliver Stegle and Gaffney, {Daniel J.}",

year = "2017",

month = jun,

day = "15",

doi = "10.1038/nature22403",

language = "English",

volume = "546",

pages = "370--+",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7658",

}

Kilpinen, H, Goncalves, A, Leha, A, Afzal, V, Alasoo, K, Ashford, S, Bala, S, Bensaddek, D, Casale, FP, Ulley, OJC, Danecek, P, Faulconbridge, A, Harrison, PW, Kathuria, A, McCarthy, D, McCarthy, SA, Meleckyte, R, Memari, Y, Moens, N, Soares, F, Mann, A, Streeter, I, Agu, CA, Alderton, A, Nelson, R, Harper, S, Patel, M, White, A, Patel, SR, Clarke, L, Halai, R, Kirton, CM, Kolb-Kokocinski, A, Beales, P, Birney, E, Danovi, D, Lamond, AI, Ouwehand, WH, Vallier, L, Watt, FM, Durbin, R, Stegle, O & Gaffney, DJ 2017, 'Common genetic variation drives molecular heterogeneity in human iPSCs', Nature, vol. 546, nr. 7658, s. 370-+. https://doi.org/10.1038/nature22403

TY - JOUR

T1 - Common genetic variation drives molecular heterogeneity in human iPSCs

AU - Kilpinen, Helena

AU - Goncalves, Angela

AU - Leha, Andreas

AU - Afzal, Vackar

AU - Alasoo, Kaur

AU - Ashford, Sofie

AU - Bala, Sendu

AU - Bensaddek, Dalila

AU - Casale, Francesco Paolo

AU - Ulley, Oliver J. C.

AU - Danecek, Petr

AU - Faulconbridge, Adam

AU - Harrison, Peter W.

AU - Kathuria, Annie

AU - McCarthy, Davis

AU - McCarthy, Shane A.

AU - Meleckyte, Ruta

AU - Memari, Yasin

AU - Moens, Nathalie

AU - Soares, Filipa

AU - Mann, Alice

AU - Streeter, Ian

AU - Agu, Chukwuma A.

AU - Alderton, Alex

AU - Nelson, Rachel

AU - Harper, Sarah

AU - Patel, Minal

AU - White, Alistair

AU - Patel, Sharad R.

AU - Clarke, Laura

AU - Halai, Reena

AU - Kirton, Christopher M.

AU - Kolb-Kokocinski, Anja

AU - Beales, Philip

AU - Birney, Ewan

AU - Danovi, Davide

AU - Lamond, Angus I.

AU - Ouwehand, Willem H.

AU - Vallier, Ludovic

AU - Watt, Fiona M.

AU - Durbin, Richard

AU - Stegle, Oliver

AU - Gaffney, Daniel J.

PY - 2017/6/15

Y1 - 2017/6/15

KW - PLURIPOTENT STEM-CELLS

KW - GENOME-WIDE ASSOCIATION

KW - CANCER RISK LOCI

KW - SUSCEPTIBILITY LOCI

KW - COPY NUMBER

KW - BREAST-CANCER

KW - DNA METHYLATION

KW - MULTIPLE COMMON

KW - CELIAC-DISEASE

KW - EXPRESSION

U2 - 10.1038/nature22403

DO - 10.1038/nature22403

M3 - Article

VL - 546

SP - 370-+

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7658

ER -