Comparison of clinically relevant oncolytic virus platforms for enhancing T-cell therapy of solid tumors

Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Riikka Havunen, Joao M. Santos, Emma Kutvonen, James H.A. Clubb, Mikko Siurala, Camilla Heiniö, Sadia Zafar, Teija Koivula, Dave Lumen, Marjo Vaha, Arturo Garcia-Horsman, Anu J. Airaksinen, Suvi Sorsa, Marjukka Anttila, Veijo Hukkanen, Anna Kanerva, Akseli Hemminki

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Despite some promising results, the majority of patients do not benefit from T-cell therapies, as tumors prevent T-cells from entering the tumor, shut down their activity, or downregulate key antigens. Due to their nature and mechanism of action, oncolytic viruses have features that can help overcome many of the barriers currently facing T-cell therapies of solid tumors. This study aims to understand how four different oncolytic viruses (adenovirus, vaccinia virus, herpes simplex virus and reovirus) perform in that task. For that purpose, an immunocompetent in vivo tumor model featuring adoptive tumor-infiltrating lymphocyte (TIL) therapy was used. Tumor growth control (p
Originalspråkengelska
TidskriftMolecular Therapy - Oncolytics
ISSN2372-7705
DOI
StatusPublicerad - 19 mar 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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  • 3122 Cancersjukdomar

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