Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques.

Rinne Petteri, Sanna Hellberg, Max Kiugel, Jenni Virta, Xiang-Guo Li, Meeri Käkelä, Kerttuli Helariutta, Pauliina Luoto, Heidi Liljenbäck, Harri Hakovirta, Maria Gardberg, Anu J. Airaksinen, Juhani Knuuti, Antti Saraste, Anne Roivainen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning


Purpose
Rupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [68Ga]DOTANOC, [18F]FDR-NOC, and [68Ga]DOTATATE, can detect inflamed atherosclerotic plaques.
Procedures
Atherosclerotic IGF-II/LDLR−/−ApoB100/100 mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [68Ga]DOTANOC and [68Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics.
Results
Ex vivo uptake of [68Ga]DOTANOC and [68Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [18F]FDR-NOC showed no genotype difference. Unlike [18F]FDR-NOC, [68Ga]DOTANOC and [68Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [68Ga]DOTANOC were higher compared to [68Ga]DOTATATE in in vivo PET/CT imaging.
Conclusion
Our results demonstrate superior applicability for [68Ga]DOTANOC and [68Ga]DOTATATE in the detection of atherosclerotic plaques compared to [18F]FDR-NOC.
Originalspråkengelska
TidskriftMolecular Imaging and Biology
Volym18
Utgåva1
Sidor (från-till)99-108
Antal sidor10
ISSN1536-1632
DOI
StatusPublicerad - feb 2016
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 116 Kemi
  • 317 Farmaci

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Petteri, Rinne ; Hellberg, Sanna ; Kiugel, Max ; Virta, Jenni ; Li, Xiang-Guo ; Käkelä, Meeri ; Helariutta, Kerttuli ; Luoto, Pauliina ; Liljenbäck, Heidi ; Hakovirta, Harri ; Gardberg, Maria ; Airaksinen, Anu J. ; Knuuti, Juhani ; Saraste, Antti ; Roivainen, Anne. / Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques. I: Molecular Imaging and Biology. 2016 ; Vol. 18, Nr. 1. s. 99-108.
@article{6575c69d9733493ea5392266bbed56a5,
title = "Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques.",
abstract = "PurposeRupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [68Ga]DOTANOC, [18F]FDR-NOC, and [68Ga]DOTATATE, can detect inflamed atherosclerotic plaques.ProceduresAtherosclerotic IGF-II/LDLR−/−ApoB100/100 mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [68Ga]DOTANOC and [68Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics.ResultsEx vivo uptake of [68Ga]DOTANOC and [68Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [18F]FDR-NOC showed no genotype difference. Unlike [18F]FDR-NOC, [68Ga]DOTANOC and [68Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [68Ga]DOTANOC were higher compared to [68Ga]DOTATATE in in vivo PET/CT imaging.ConclusionOur results demonstrate superior applicability for [68Ga]DOTANOC and [68Ga]DOTATATE in the detection of atherosclerotic plaques compared to [18F]FDR-NOC.",
keywords = "116 Chemical sciences, 317 Pharmacy",
author = "Rinne Petteri and Sanna Hellberg and Max Kiugel and Jenni Virta and Xiang-Guo Li and Meeri K{\"a}kel{\"a} and Kerttuli Helariutta and Pauliina Luoto and Heidi Liljenb{\"a}ck and Harri Hakovirta and Maria Gardberg and Airaksinen, {Anu J.} and Juhani Knuuti and Antti Saraste and Anne Roivainen",
year = "2016",
month = "2",
doi = "10.1007/s11307-015-0873-1",
language = "English",
volume = "18",
pages = "99--108",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "SPRINGER NEW YORK LLC",
number = "1",

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Petteri, R, Hellberg, S, Kiugel, M, Virta, J, Li, X-G, Käkelä, M, Helariutta, K, Luoto, P, Liljenbäck, H, Hakovirta, H, Gardberg, M, Airaksinen, AJ, Knuuti, J, Saraste, A & Roivainen, A 2016, 'Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques.', Molecular Imaging and Biology, vol. 18, nr. 1, s. 99-108. https://doi.org/10.1007/s11307-015-0873-1

Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques. / Petteri, Rinne; Hellberg, Sanna; Kiugel, Max; Virta, Jenni; Li, Xiang-Guo; Käkelä, Meeri; Helariutta, Kerttuli; Luoto, Pauliina; Liljenbäck, Heidi; Hakovirta, Harri; Gardberg, Maria; Airaksinen, Anu J.; Knuuti, Juhani; Saraste, Antti; Roivainen, Anne.

I: Molecular Imaging and Biology, Vol. 18, Nr. 1, 02.2016, s. 99-108.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques.

AU - Petteri, Rinne

AU - Hellberg, Sanna

AU - Kiugel, Max

AU - Virta, Jenni

AU - Li, Xiang-Guo

AU - Käkelä, Meeri

AU - Helariutta, Kerttuli

AU - Luoto, Pauliina

AU - Liljenbäck, Heidi

AU - Hakovirta, Harri

AU - Gardberg, Maria

AU - Airaksinen, Anu J.

AU - Knuuti, Juhani

AU - Saraste, Antti

AU - Roivainen, Anne

PY - 2016/2

Y1 - 2016/2

N2 - PurposeRupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [68Ga]DOTANOC, [18F]FDR-NOC, and [68Ga]DOTATATE, can detect inflamed atherosclerotic plaques.ProceduresAtherosclerotic IGF-II/LDLR−/−ApoB100/100 mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [68Ga]DOTANOC and [68Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics.ResultsEx vivo uptake of [68Ga]DOTANOC and [68Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [18F]FDR-NOC showed no genotype difference. Unlike [18F]FDR-NOC, [68Ga]DOTANOC and [68Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [68Ga]DOTANOC were higher compared to [68Ga]DOTATATE in in vivo PET/CT imaging.ConclusionOur results demonstrate superior applicability for [68Ga]DOTANOC and [68Ga]DOTATATE in the detection of atherosclerotic plaques compared to [18F]FDR-NOC.

AB - PurposeRupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [68Ga]DOTANOC, [18F]FDR-NOC, and [68Ga]DOTATATE, can detect inflamed atherosclerotic plaques.ProceduresAtherosclerotic IGF-II/LDLR−/−ApoB100/100 mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [68Ga]DOTANOC and [68Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics.ResultsEx vivo uptake of [68Ga]DOTANOC and [68Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [18F]FDR-NOC showed no genotype difference. Unlike [18F]FDR-NOC, [68Ga]DOTANOC and [68Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [68Ga]DOTANOC were higher compared to [68Ga]DOTATATE in in vivo PET/CT imaging.ConclusionOur results demonstrate superior applicability for [68Ga]DOTANOC and [68Ga]DOTATATE in the detection of atherosclerotic plaques compared to [18F]FDR-NOC.

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1007/s11307-015-0873-1

DO - 10.1007/s11307-015-0873-1

M3 - Article

VL - 18

SP - 99

EP - 108

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 1

ER -